The University of Southampton
University of Southampton Institutional Repository

Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers
Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers
Background: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

Methods: Genotyping data for 12,599 BRCA1 and 7,132 BRCA2 mutation carriers from 40 studies were combined.

Results: We confirmed associations between rs8170 at 19p13.1 and breast cancer risk for BRCA1 mutation carriers [HR, 1.17; 95% confidence interval (CI), 1.07-1.27; P = 7.42 × 10(-4)] and between rs16917302 at ZNF365 (HR, 0.84; 95% CI, 0.73-0.97; P = 0.017) but not rs311499 at 20q13.3 (HR, 1.11; 95% CI, 0.94-1.31; P = 0.22) and breast cancer risk for BRCA2 mutation carriers. Analyses based on tumor histopathology showed that 19p13 variants were predominantly associated with estrogen receptor (ER)-negative breast cancer for both BRCA1 and BRCA2 mutation carriers, whereas rs16917302 at ZNF365 was mainly associated with ER-positive breast cancer for both BRCA1 and BRCA2 mutation carriers. We also found for the first time that rs67397200 at 19p13.1 was associated with an increased risk of ovarian cancer for BRCA1 (HR, 1.16; 95% CI, 1.05-1.29; P = 3.8 × 10(-4)) and BRCA2 mutation carriers (HR, 1.30; 95% CI, 1.10-1.52; P = 1.8 × 10(-3)).

Conclusions: 19p13.1 and ZNF365 are susceptibility loci for ovarian cancer and ER subtypes of breast cancer among BRCA1 and BRCA2 mutation carriers.

Impact: These findings can lead to an improved understanding of tumor development and may prove useful for breast and ovarian cancer risk prediction for BRCA1 and BRCA2 mutation carriers.
1055-9965
645-657
Couch, Fergus J.
778e32f1-0b19-4cf4-b38f-69dd027cad3a
Gaudet, Mia M.
5ab8150b-b9b0-4666-8afe-70d5d662eaa6
Antoniou, Antonis C.
b5275276-df7e-42a4-9a38-6a9516924f0d
Ramus, Susan J.
f2a91d0b-8aab-4e57-b49f-7637767b4f57
Kuchenbaecker, Karoline B.
c72c2a25-9297-47bc-a4c0-f6e135ed0854
Soucy, Penny
c8606457-7865-44a4-90ce-de2b55994738
Beesley, Jonathan
0ec7ea7e-d634-48f5-9a1a-89158c82597d
Chen, Xiaoqing
ee420c6c-2134-49d2-8238-514d837c725f
Wang, Xianshu
5c376f01-823c-4228-bd76-414a181fa3eb
Kirchhoff, Tomas
efb7571f-f43d-489e-ae81-44fa2168e9af
McGuffog, Lesley
21522096-38bb-45df-aa56-caf2f27d7254
Barrowdale, Daniel
507bc817-9e80-4ff2-a379-470e0d6ed2c9
Lee, Andrew
a82db836-29cd-4bf5-a96a-fb6af545b310
Healey, Sue
5d595192-5381-464d-85cc-71ad09a05065
Sinilnikova, Olga M.
17bb19c7-8db3-48e3-8630-0c9a78a2e1a4
Andrulis, Irene L.
bc0d05b1-2437-452a-b9df-0d31cfbe1435
Ozcelik, Hilmi
afe78ba7-45e4-45e9-a763-fcadbc9327fa
Mulligan, Anna Marie
a999fb4f-9064-4311-90fc-3e8e80a5458a
Thomassen, Mads
c7c9230a-4f3d-42d0-89f1-b5a36d431aae
Gerdes, Anne-Marie
60e03234-c7bd-4659-a642-432c0f943474
Jensen, Uffe Birk
1d7b3fd2-94fc-448f-8b0e-2a5d66815233
Skytte, Anne-Bine
c5d3bada-dddb-410f-b19f-ba2d9c00f657
Kruse, Torben A.
b53a27bc-4eda-44dd-b479-345f5dfda90f
Caligo, Maria A.
8fd95b7b-5e69-4f7f-9513-50b3d5e86ef6
von Wachenfeldt, Anna
fac5b2fc-5f7c-4b95-b123-79ed481bbff0
Barbany-Bustinza, Gisela
9180a28c-00c3-46a9-970d-92482130b219
Loman, Niklas
e075acfa-7d57-4782-b4ba-cb0bb472b25c
Soller, Maria
b731e46c-3010-4091-96bd-d0ea1f7839e7
Ehrencrona, Hans
3bf9759a-7b66-4492-833a-db923bc49324
Karlsson, Per
cf6072fc-3103-402a-9271-2c37bdeee52d
Nathanson, Katherine L.
595fa51d-4601-446d-85ff-9151c5f9246a
Rebbeck, Timothy R.
017e04fa-fcd5-48d2-89f5-2e05f4c2091a
Domchek, Susan M.
7d99c293-81c9-4f0e-ab2c-e2655e2b601e
Jakubowska, Ania
f7f4d98b-a269-43e6-9f66-0769331ab8a9
Lubinski, Jan
e7a9709c-36b3-44ed-a5e0-675177ca3d51
Jaworska, Katarzyna
f889ceb7-0ba9-4571-90cc-a4fee037debf
Durda, Katarzyna
61bc19e0-811f-49a7-93c9-120f84525fda
Zlowocka, Elżbieta
cd03bbf7-e1ba-4bc8-9f81-f22da118c69e
Huzarski, Tomasz
66e38515-375a-430f-9528-41912816378d
Byrski, Tomasz
9cb401e1-f220-4cab-b2c6-566bd3877c24
Gronwald, Jacek
4a0117ac-84f8-4351-a97d-637a60db25f6
Cybulski, Cezary
6c6cf54d-5e0e-4395-b8bb-7f1691a90e7f
Gorski, Bohdan
e7182394-3a1a-4703-9471-0f5674af6090
Osorio, Ana
5d37d9d7-d889-4e14-ad7c-7b7f73f6e299
Duran, Mercedes
4fdd02a6-6b47-4449-b245-ed10df4a5f0c
Tejada, María Isabel
9d68698b-1745-464d-b2c9-3300e9f26bb6
Benitez, Javier
aaf768e0-3166-4656-a787-89512ca1828c
Hamann, Ute
c47a5052-5e7b-492c-988b-38b7df2cffc6
Hogervorst, Frans B.L.
ed37f627-0663-44d8-9067-e921fd700909
van Os, Theo A.
1bc277ed-8e74-4571-9bc2-1ac9ec26369c
van Leeuwen, Flora E.
89d7c75b-228f-4c71-828b-c92b5e5ae42e
Meijers-Heijboer, Hanne E.J.
1662d152-1979-4cea-a8ba-49242bf0985b
Wijnen, Juul
1556ff67-a692-4d20-b2a8-d0869985558e
Blok, Marinus J.
0fe408b6-18f4-46f6-9b69-f42b8b1f6e06
Kets, Marleen
5d550373-0982-43af-a937-cf834f504a2c
Hooning, Maartje J.
3119c176-c241-4a30-b6c9-26f0dc3f912c
Oldenburg, Rogier A.
6df13e0b-db74-4171-9299-35d87c026c0d
Ausems, Margreet G.E.M.
25eb17d5-51dc-4aae-9c60-1a57f67bb648
Peock, Susan
7e420471-9ee5-4a07-9536-bfdc4c6f1297
Frost, Debra
38874d28-24d7-47b2-b458-b121539a3ceb
Ellis, Steve D.
b7eac29f-f2c3-4fd7-9bd2-8eed9d25b07e
Platte, Radka
23a1b828-b2b0-4504-a668-ce2e51888a52
Fineberg, Elena
93a15f00-4fc7-4cbe-8b55-d1fc5357b19b
Evans, D. Gareth
314acefb-89fb-4eb7-a0e7-0a6949c9af6c
Jacobs, Chris
44495416-d1d5-4520-96e6-c1f077793e5f
Eeles, Rosalind A.
b11a81ed-c0fc-4edc-a3b9-bbc300f19576
Adlard, Julian
3a01574a-8ed1-4286-956c-c9e87fd89521
Davidson, Rosemarie
81692cd9-0a70-4a01-a68f-8eb623f0fbe0
Eccles, Diana M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Cole, Trevor
5d7a1e62-1c71-4b07-acdd-652f08f153d4
Cook, Jackie
b24e3336-f47a-4590-bc3f-7e2ab7d78e0d
Paterson, Joan
79204243-74c8-46f7-881b-091043581334
Brewer, Carole
f497c7f3-050d-4494-aecb-7e6a23101d18
Douglas, Fiona
a35f2e38-4fc4-481e-a212-1e3ae5d5ae0c
Hodgson, Shirley V.
d30bfe9d-092f-4e12-8327-04386bb77c77
Morrison, Patrick J.
0fb9bdda-83c3-446b-ae97-28858f06d2d8
Walker, Lisa
682b9d2c-3469-416e-b9dc-a5c68626fba7
Porteous, Mary E.
05990ca3-1e88-43d9-983f-d1853589433b
Kennedy, M. John
8f7b041a-5c5e-415a-acc1-83192f80654c
Side, Lucy E.
f9e1faa2-2814-4c9e-8470-65d0f92ddcd6
Bove, Betsy
70649bc0-1eda-499c-bc94-ac3b26089a1b
Godwin, Andrew K.
a7e89dce-59e1-48f7-b668-42777f362435
Stoppa-Lyonnet, Dominique
c110a3bd-17a1-4b82-9b32-75728172bfc5
Fassy-Colcombet, Marion
7b832ef0-f75b-4d64-b1cd-dda5f203c05a
Castera, Laurent
d1990d3f-380f-4d65-955e-e9c09e231d7c
Cornelis, François
563da245-2cf6-4631-989a-7204180d4f4f
Mazoyer, Sylvie
6e0e32e4-7d0e-4c7c-bd80-d221d53af542
Leone, Mélanie
178c72e4-1a64-43c1-9cec-141fcf2b92a5
Boutry-Kryza, Nadia
49b27e76-3081-4325-93ee-7302522d2a8b
Bressac-de Paillerets, Brigitte
80bc1751-7dac-45be-a821-0d04522d1382
Caron, Olivier
bb3577e1-0293-4a54-973f-71e4297d444b
Pujol, Pascal
c2d9280d-450d-4000-95bf-2d3d81ba0a15
Coupier, Isabelle
97ca1b6d-db10-4fd8-b8bb-e76eb6fd1c37
Delnatte, Capuchine
1757c3ff-ddc7-4b2d-b20c-4884f4ecc216
Akloul, Linda
177d448c-e053-4616-a82d-5139798a5acb
Lynch, Henry T.
4515a3de-428a-476c-ad48-621c7928e874
Snyder, Carrie L.
f279b140-9acf-4350-8c1e-5efc0ad75745
Buys, Saundra S.
5b1a7cea-6562-4fb0-b2a9-06b08d5e86e6
Daly, Mary B.
7d327e18-8795-40e7-af04-5dad9a3f82aa
Terry, MaryBeth
c4d10c8d-a93d-4a53-b755-5a0568f52e40
Chung, Wendy K.
c7c336a6-b597-432b-b8df-abd1a2d3de14
John, Esther M.
52870193-e535-4d25-ab4d-11d221ea99ff
Miron, Alexander
74adb82c-6a80-44bb-9716-a8281da0ccaf
Southey, Melissa C.
56062dff-748c-47e4-99f5-044cff9da594
Hopper, John L.
bdd6f4f6-9121-4cd6-824d-b3b92bd4babf
Goldgar, David E.
102af7b6-41ab-46c0-9d76-43359c897e2e
Singer, Christian F.
3ac2e574-0627-4715-ac4a-8ab7edcc3851
Rappaport, Christine
6601215f-18f5-482d-b6c0-b0ee380786b6
Tea, Muy-Kheng M.
1a4db823-8062-4e6e-8b23-b5590d0c7cf8
Fink-Retter, Anneliese
5204f14d-94b4-4fa8-9886-3b2dbd00274a
Hansen, Thomas V.O.
72f8a6c2-3e25-4698-9521-d2fa7d619647
Nielsen, Finn C.
38defc00-22e2-4d73-9ad3-18a4115d926c
Arason, Aðalgeir
dfd09f69-84ee-4164-bf27-54f5090caea1
Vijai, Joseph
f3405060-d901-46b7-acd0-d60988e5e1fd
Shah, Sohela
27c5f67e-7723-4ba6-8c2d-eee7b2a468bd
Sarrel, Kara
77068f7d-3a7b-4dd5-91e4-ef81f576643c
Robson, Mark E.
973acc09-2e65-4b68-b695-3bc0ee1436f7
Piedmonte, Marion
db992162-8488-4999-b1e8-0c1cf10871e7
Phillips, Kelly
ab6fbba6-cdb8-4b53-902f-84b0e6d9f303
Basil, Jack
fe0ee4ad-0347-4217-b38c-3cb060a64097
Rubinstein, Wendy S.
c49e76ce-fba0-4a9c-a105-d4fef955ab23
Boggess, John
c08cb7f2-aff8-45cf-817a-7ea78b68cd71
Wakeley, Katie
84a85bdf-82ce-44a0-b3c0-6671a0625b95
Ewart-Toland, Amanda
8ef95576-249e-496c-8d8f-8931e2cc2c4c
Montagna, Marco
1e04949f-87c3-4ca4-a772-5d59a9407f07
Agata, Simona
298af9cb-3400-4f47-9d15-060b387369b8
Imyanitov, Evgeny N.
fcad02c1-95af-47aa-9b1b-3ea64cd20d99
Isaacs, Claudine
6e60951b-1f07-471a-8ca3-1941e83bbf83
Janavicius, Ramunas
314ff9ed-91c2-49cc-aa80-5ab072225a98
Lazaro, Conxi
34576bd1-4cfb-4b16-9a51-78bdd7057bd7
Blanco, Ignacio
27cfc95d-deca-4fc4-8bfb-c162edd24e0e
Feliubadalo, Lidia
c9bcdfd8-ff39-44bb-9ebd-4e8d8de9586b
Brunet, Joan
802a3fdd-e1e0-4ee0-a7b6-43a4adf67f13
Gayther, Simon A.
5333cc14-fc1e-4517-9808-be39b0fb009c
Pharoah, Paul P.D.
1847d2c6-9424-4d39-ab56-7ba81b6bef52
Odunsi, Kunle O.
f3daa9a1-5ff0-4168-b76c-f68cd63f8c98
Karlan, Beth Y.
0a74d552-f43d-4670-bc0c-0f860d55b15e
Walsh, Christine S.
33eec273-b0d3-4723-97be-9692b3d26922
Olah, Edith
f4ee7e40-b263-490e-96fc-84b98eb2ec20
Teo, Soo Hwang
f48023c5-9e80-487b-83c7-f09563a9579d
Ganz, Patricia A.
e7573e53-13b2-4291-80d8-a59249b827fe
Beattie, Mary S.
5d70bae8-abdb-4845-831a-3e0ac9a8a7ca
van Rensburg, Elizabeth J.
d4dd3b97-d9ee-4968-97f4-4e8aa97c574a
Dorfling, Cecelia M.
1538d501-b35d-477c-bc48-b82bc0859d06
Diez, Orland
35522b1a-2862-43ce-b8e9-50f60579c671
Kwong, Ava
0e3a4ee7-f400-4da7-8a3c-9183eb75ac66
Schmutzler, Rita K.
bf790f2e-79f3-4151-a74c-793bf14d8f6a
Wappenschmidt, Barbara
b196c313-8a35-4e32-a020-10181ac41400
Engel, Christoph
e428d3b6-d668-487c-bcef-7d835e609751
Meindl, Alfons
10b41dbc-4030-4b19-976f-212367b636af
Ditsch, Nina
f065f653-f2a5-4099-887b-65de0fb74d8c
Arnold, Norbert
2296ee7c-7ba5-48cb-8514-c0a9c4a25eb9
Heidemann, Simone
9a2848a0-f319-4627-abd2-334b7e638074
Niederacher, Dieter
b6a4a233-f88d-416b-a22e-9902d732d8e6
Preisler-Adams, Sabine
82c50384-58e6-4299-a125-9b2c26413d32
Gadzicki, Dorothea
b4f1469f-e0a9-4feb-b125-8f45bb99f03f
Varon-Mateeva, Raymonda
93a22b00-7e87-4296-b2da-82caf74bebfc
Deissler, Helmut
58cbec72-5288-4cdd-9e55-f0ca1331bb53
Gehrig, Andrea
39f42e5e-96be-4734-9ac9-0d4bf4cdcbae
Sutter, Christian
c54383c2-0738-42cc-b0ab-c2595b4ec272
Kast, Karin
7cde00f5-f897-4c84-bb86-2ecdd6e23b6d
Fiebig, Britta
86a99d73-caa3-4b21-9361-a50646910deb
Heinritz, Wolfram
4b28742f-cde3-44ae-912b-8ba89ca57fbe
Caldes, Trinidad
8caab9c0-bec3-44d5-8e98-c97ee3ebda7d
de la Hoya, Miguel
8e170da0-2396-4f84-ba15-14fa2ad62fb2
Muranen, Tara A.
c74b6d5b-d1fb-497b-a913-526750610ccc
Nevanlinna, Heli
69be7a44-2abf-4504-a47b-a50b6723701b
Tischkowitz, Marc D.
26d4f395-beb7-41d7-89d5-d3430c9de0cf
Spurdle, Amanda B.
8158d468-cc96-4e39-9bac-fcaaa7061a72
Neuhausen, Susan L.
7cb359d3-5964-460c-ad60-63b77368c042
Ding, Yuan Chun
107aa0a1-2546-46b0-a1e5-a9d6dcb26744
Lindor, Noralane M.
95f60dee-421b-4055-a396-a3b05371762f
Fredericksen, Zachary
77db03d0-8de3-49c7-9a20-c9d6f84027a0
Pankratz, V. Shane
bd3ea90e-e906-41ed-846b-d012c6c30610
Peterlongo, Paolo
af3f3db4-e3fc-45db-bbb4-91954fe857fb
Manoukian, Siranoush
87f7b60d-b65f-4655-b1d8-3b7c5dcf37d2
Peissel, Bernard
94da3e26-04ab-4665-905a-aa21969c7a94
Zaffaroni, Daniela
f88dddd8-5392-415d-bbbb-c3d8e146ecb0
Barile, Monica
6cf202cf-6024-4f42-b74c-d807c79632a7
Bernard, Loris
0a345750-134d-4b15-84a6-0c7ba05efe9b
Viel, Alessandra
1d927ea7-bf84-419a-aff1-6d65b67c1280
Giannini, Giuseppe
23e46760-a759-4bd8-8096-550a02b87e43
Varesco, Liliana
07ebbeb9-3165-4a50-a227-d0896d53e86e
Radice, Paolo
d5bff2d9-ed03-4a8e-a9ca-f896a1666e2c
Greene, Mark H.
aefbcd26-0def-47a3-8580-0c56feb03756
Mai, Phuong L.
31cb800d-d6a7-4aa0-b590-4e8668ce303a
Easton, Douglas F.
2661cf5e-8fc6-4f1d-b27a-e60cac8c8819
Chenevix-Trench, Georgia
7d222914-c6e5-47b8-9022-5874b7c82a3e
Offit, Kenneth
ce1fc8a6-b5ac-434a-9d2d-4a7e1ee7ca7c
Simard, Jacques
6269fd00-31ae-40f0-b016-5f60cb9f5b96
Couch, Fergus J.
778e32f1-0b19-4cf4-b38f-69dd027cad3a
Gaudet, Mia M.
5ab8150b-b9b0-4666-8afe-70d5d662eaa6
Antoniou, Antonis C.
b5275276-df7e-42a4-9a38-6a9516924f0d
Ramus, Susan J.
f2a91d0b-8aab-4e57-b49f-7637767b4f57
Kuchenbaecker, Karoline B.
c72c2a25-9297-47bc-a4c0-f6e135ed0854
Soucy, Penny
c8606457-7865-44a4-90ce-de2b55994738
Beesley, Jonathan
0ec7ea7e-d634-48f5-9a1a-89158c82597d
Chen, Xiaoqing
ee420c6c-2134-49d2-8238-514d837c725f
Wang, Xianshu
5c376f01-823c-4228-bd76-414a181fa3eb
Kirchhoff, Tomas
efb7571f-f43d-489e-ae81-44fa2168e9af
McGuffog, Lesley
21522096-38bb-45df-aa56-caf2f27d7254
Barrowdale, Daniel
507bc817-9e80-4ff2-a379-470e0d6ed2c9
Lee, Andrew
a82db836-29cd-4bf5-a96a-fb6af545b310
Healey, Sue
5d595192-5381-464d-85cc-71ad09a05065
Sinilnikova, Olga M.
17bb19c7-8db3-48e3-8630-0c9a78a2e1a4
Andrulis, Irene L.
bc0d05b1-2437-452a-b9df-0d31cfbe1435
Ozcelik, Hilmi
afe78ba7-45e4-45e9-a763-fcadbc9327fa
Mulligan, Anna Marie
a999fb4f-9064-4311-90fc-3e8e80a5458a
Thomassen, Mads
c7c9230a-4f3d-42d0-89f1-b5a36d431aae
Gerdes, Anne-Marie
60e03234-c7bd-4659-a642-432c0f943474
Jensen, Uffe Birk
1d7b3fd2-94fc-448f-8b0e-2a5d66815233
Skytte, Anne-Bine
c5d3bada-dddb-410f-b19f-ba2d9c00f657
Kruse, Torben A.
b53a27bc-4eda-44dd-b479-345f5dfda90f
Caligo, Maria A.
8fd95b7b-5e69-4f7f-9513-50b3d5e86ef6
von Wachenfeldt, Anna
fac5b2fc-5f7c-4b95-b123-79ed481bbff0
Barbany-Bustinza, Gisela
9180a28c-00c3-46a9-970d-92482130b219
Loman, Niklas
e075acfa-7d57-4782-b4ba-cb0bb472b25c
Soller, Maria
b731e46c-3010-4091-96bd-d0ea1f7839e7
Ehrencrona, Hans
3bf9759a-7b66-4492-833a-db923bc49324
Karlsson, Per
cf6072fc-3103-402a-9271-2c37bdeee52d
Nathanson, Katherine L.
595fa51d-4601-446d-85ff-9151c5f9246a
Rebbeck, Timothy R.
017e04fa-fcd5-48d2-89f5-2e05f4c2091a
Domchek, Susan M.
7d99c293-81c9-4f0e-ab2c-e2655e2b601e
Jakubowska, Ania
f7f4d98b-a269-43e6-9f66-0769331ab8a9
Lubinski, Jan
e7a9709c-36b3-44ed-a5e0-675177ca3d51
Jaworska, Katarzyna
f889ceb7-0ba9-4571-90cc-a4fee037debf
Durda, Katarzyna
61bc19e0-811f-49a7-93c9-120f84525fda
Zlowocka, Elżbieta
cd03bbf7-e1ba-4bc8-9f81-f22da118c69e
Huzarski, Tomasz
66e38515-375a-430f-9528-41912816378d
Byrski, Tomasz
9cb401e1-f220-4cab-b2c6-566bd3877c24
Gronwald, Jacek
4a0117ac-84f8-4351-a97d-637a60db25f6
Cybulski, Cezary
6c6cf54d-5e0e-4395-b8bb-7f1691a90e7f
Gorski, Bohdan
e7182394-3a1a-4703-9471-0f5674af6090
Osorio, Ana
5d37d9d7-d889-4e14-ad7c-7b7f73f6e299
Duran, Mercedes
4fdd02a6-6b47-4449-b245-ed10df4a5f0c
Tejada, María Isabel
9d68698b-1745-464d-b2c9-3300e9f26bb6
Benitez, Javier
aaf768e0-3166-4656-a787-89512ca1828c
Hamann, Ute
c47a5052-5e7b-492c-988b-38b7df2cffc6
Hogervorst, Frans B.L.
ed37f627-0663-44d8-9067-e921fd700909
van Os, Theo A.
1bc277ed-8e74-4571-9bc2-1ac9ec26369c
van Leeuwen, Flora E.
89d7c75b-228f-4c71-828b-c92b5e5ae42e
Meijers-Heijboer, Hanne E.J.
1662d152-1979-4cea-a8ba-49242bf0985b
Wijnen, Juul
1556ff67-a692-4d20-b2a8-d0869985558e
Blok, Marinus J.
0fe408b6-18f4-46f6-9b69-f42b8b1f6e06
Kets, Marleen
5d550373-0982-43af-a937-cf834f504a2c
Hooning, Maartje J.
3119c176-c241-4a30-b6c9-26f0dc3f912c
Oldenburg, Rogier A.
6df13e0b-db74-4171-9299-35d87c026c0d
Ausems, Margreet G.E.M.
25eb17d5-51dc-4aae-9c60-1a57f67bb648
Peock, Susan
7e420471-9ee5-4a07-9536-bfdc4c6f1297
Frost, Debra
38874d28-24d7-47b2-b458-b121539a3ceb
Ellis, Steve D.
b7eac29f-f2c3-4fd7-9bd2-8eed9d25b07e
Platte, Radka
23a1b828-b2b0-4504-a668-ce2e51888a52
Fineberg, Elena
93a15f00-4fc7-4cbe-8b55-d1fc5357b19b
Evans, D. Gareth
314acefb-89fb-4eb7-a0e7-0a6949c9af6c
Jacobs, Chris
44495416-d1d5-4520-96e6-c1f077793e5f
Eeles, Rosalind A.
b11a81ed-c0fc-4edc-a3b9-bbc300f19576
Adlard, Julian
3a01574a-8ed1-4286-956c-c9e87fd89521
Davidson, Rosemarie
81692cd9-0a70-4a01-a68f-8eb623f0fbe0
Eccles, Diana M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Cole, Trevor
5d7a1e62-1c71-4b07-acdd-652f08f153d4
Cook, Jackie
b24e3336-f47a-4590-bc3f-7e2ab7d78e0d
Paterson, Joan
79204243-74c8-46f7-881b-091043581334
Brewer, Carole
f497c7f3-050d-4494-aecb-7e6a23101d18
Douglas, Fiona
a35f2e38-4fc4-481e-a212-1e3ae5d5ae0c
Hodgson, Shirley V.
d30bfe9d-092f-4e12-8327-04386bb77c77
Morrison, Patrick J.
0fb9bdda-83c3-446b-ae97-28858f06d2d8
Walker, Lisa
682b9d2c-3469-416e-b9dc-a5c68626fba7
Porteous, Mary E.
05990ca3-1e88-43d9-983f-d1853589433b
Kennedy, M. John
8f7b041a-5c5e-415a-acc1-83192f80654c
Side, Lucy E.
f9e1faa2-2814-4c9e-8470-65d0f92ddcd6
Bove, Betsy
70649bc0-1eda-499c-bc94-ac3b26089a1b
Godwin, Andrew K.
a7e89dce-59e1-48f7-b668-42777f362435
Stoppa-Lyonnet, Dominique
c110a3bd-17a1-4b82-9b32-75728172bfc5
Fassy-Colcombet, Marion
7b832ef0-f75b-4d64-b1cd-dda5f203c05a
Castera, Laurent
d1990d3f-380f-4d65-955e-e9c09e231d7c
Cornelis, François
563da245-2cf6-4631-989a-7204180d4f4f
Mazoyer, Sylvie
6e0e32e4-7d0e-4c7c-bd80-d221d53af542
Leone, Mélanie
178c72e4-1a64-43c1-9cec-141fcf2b92a5
Boutry-Kryza, Nadia
49b27e76-3081-4325-93ee-7302522d2a8b
Bressac-de Paillerets, Brigitte
80bc1751-7dac-45be-a821-0d04522d1382
Caron, Olivier
bb3577e1-0293-4a54-973f-71e4297d444b
Pujol, Pascal
c2d9280d-450d-4000-95bf-2d3d81ba0a15
Coupier, Isabelle
97ca1b6d-db10-4fd8-b8bb-e76eb6fd1c37
Delnatte, Capuchine
1757c3ff-ddc7-4b2d-b20c-4884f4ecc216
Akloul, Linda
177d448c-e053-4616-a82d-5139798a5acb
Lynch, Henry T.
4515a3de-428a-476c-ad48-621c7928e874
Snyder, Carrie L.
f279b140-9acf-4350-8c1e-5efc0ad75745
Buys, Saundra S.
5b1a7cea-6562-4fb0-b2a9-06b08d5e86e6
Daly, Mary B.
7d327e18-8795-40e7-af04-5dad9a3f82aa
Terry, MaryBeth
c4d10c8d-a93d-4a53-b755-5a0568f52e40
Chung, Wendy K.
c7c336a6-b597-432b-b8df-abd1a2d3de14
John, Esther M.
52870193-e535-4d25-ab4d-11d221ea99ff
Miron, Alexander
74adb82c-6a80-44bb-9716-a8281da0ccaf
Southey, Melissa C.
56062dff-748c-47e4-99f5-044cff9da594
Hopper, John L.
bdd6f4f6-9121-4cd6-824d-b3b92bd4babf
Goldgar, David E.
102af7b6-41ab-46c0-9d76-43359c897e2e
Singer, Christian F.
3ac2e574-0627-4715-ac4a-8ab7edcc3851
Rappaport, Christine
6601215f-18f5-482d-b6c0-b0ee380786b6
Tea, Muy-Kheng M.
1a4db823-8062-4e6e-8b23-b5590d0c7cf8
Fink-Retter, Anneliese
5204f14d-94b4-4fa8-9886-3b2dbd00274a
Hansen, Thomas V.O.
72f8a6c2-3e25-4698-9521-d2fa7d619647
Nielsen, Finn C.
38defc00-22e2-4d73-9ad3-18a4115d926c
Arason, Aðalgeir
dfd09f69-84ee-4164-bf27-54f5090caea1
Vijai, Joseph
f3405060-d901-46b7-acd0-d60988e5e1fd
Shah, Sohela
27c5f67e-7723-4ba6-8c2d-eee7b2a468bd
Sarrel, Kara
77068f7d-3a7b-4dd5-91e4-ef81f576643c
Robson, Mark E.
973acc09-2e65-4b68-b695-3bc0ee1436f7
Piedmonte, Marion
db992162-8488-4999-b1e8-0c1cf10871e7
Phillips, Kelly
ab6fbba6-cdb8-4b53-902f-84b0e6d9f303
Basil, Jack
fe0ee4ad-0347-4217-b38c-3cb060a64097
Rubinstein, Wendy S.
c49e76ce-fba0-4a9c-a105-d4fef955ab23
Boggess, John
c08cb7f2-aff8-45cf-817a-7ea78b68cd71
Wakeley, Katie
84a85bdf-82ce-44a0-b3c0-6671a0625b95
Ewart-Toland, Amanda
8ef95576-249e-496c-8d8f-8931e2cc2c4c
Montagna, Marco
1e04949f-87c3-4ca4-a772-5d59a9407f07
Agata, Simona
298af9cb-3400-4f47-9d15-060b387369b8
Imyanitov, Evgeny N.
fcad02c1-95af-47aa-9b1b-3ea64cd20d99
Isaacs, Claudine
6e60951b-1f07-471a-8ca3-1941e83bbf83
Janavicius, Ramunas
314ff9ed-91c2-49cc-aa80-5ab072225a98
Lazaro, Conxi
34576bd1-4cfb-4b16-9a51-78bdd7057bd7
Blanco, Ignacio
27cfc95d-deca-4fc4-8bfb-c162edd24e0e
Feliubadalo, Lidia
c9bcdfd8-ff39-44bb-9ebd-4e8d8de9586b
Brunet, Joan
802a3fdd-e1e0-4ee0-a7b6-43a4adf67f13
Gayther, Simon A.
5333cc14-fc1e-4517-9808-be39b0fb009c
Pharoah, Paul P.D.
1847d2c6-9424-4d39-ab56-7ba81b6bef52
Odunsi, Kunle O.
f3daa9a1-5ff0-4168-b76c-f68cd63f8c98
Karlan, Beth Y.
0a74d552-f43d-4670-bc0c-0f860d55b15e
Walsh, Christine S.
33eec273-b0d3-4723-97be-9692b3d26922
Olah, Edith
f4ee7e40-b263-490e-96fc-84b98eb2ec20
Teo, Soo Hwang
f48023c5-9e80-487b-83c7-f09563a9579d
Ganz, Patricia A.
e7573e53-13b2-4291-80d8-a59249b827fe
Beattie, Mary S.
5d70bae8-abdb-4845-831a-3e0ac9a8a7ca
van Rensburg, Elizabeth J.
d4dd3b97-d9ee-4968-97f4-4e8aa97c574a
Dorfling, Cecelia M.
1538d501-b35d-477c-bc48-b82bc0859d06
Diez, Orland
35522b1a-2862-43ce-b8e9-50f60579c671
Kwong, Ava
0e3a4ee7-f400-4da7-8a3c-9183eb75ac66
Schmutzler, Rita K.
bf790f2e-79f3-4151-a74c-793bf14d8f6a
Wappenschmidt, Barbara
b196c313-8a35-4e32-a020-10181ac41400
Engel, Christoph
e428d3b6-d668-487c-bcef-7d835e609751
Meindl, Alfons
10b41dbc-4030-4b19-976f-212367b636af
Ditsch, Nina
f065f653-f2a5-4099-887b-65de0fb74d8c
Arnold, Norbert
2296ee7c-7ba5-48cb-8514-c0a9c4a25eb9
Heidemann, Simone
9a2848a0-f319-4627-abd2-334b7e638074
Niederacher, Dieter
b6a4a233-f88d-416b-a22e-9902d732d8e6
Preisler-Adams, Sabine
82c50384-58e6-4299-a125-9b2c26413d32
Gadzicki, Dorothea
b4f1469f-e0a9-4feb-b125-8f45bb99f03f
Varon-Mateeva, Raymonda
93a22b00-7e87-4296-b2da-82caf74bebfc
Deissler, Helmut
58cbec72-5288-4cdd-9e55-f0ca1331bb53
Gehrig, Andrea
39f42e5e-96be-4734-9ac9-0d4bf4cdcbae
Sutter, Christian
c54383c2-0738-42cc-b0ab-c2595b4ec272
Kast, Karin
7cde00f5-f897-4c84-bb86-2ecdd6e23b6d
Fiebig, Britta
86a99d73-caa3-4b21-9361-a50646910deb
Heinritz, Wolfram
4b28742f-cde3-44ae-912b-8ba89ca57fbe
Caldes, Trinidad
8caab9c0-bec3-44d5-8e98-c97ee3ebda7d
de la Hoya, Miguel
8e170da0-2396-4f84-ba15-14fa2ad62fb2
Muranen, Tara A.
c74b6d5b-d1fb-497b-a913-526750610ccc
Nevanlinna, Heli
69be7a44-2abf-4504-a47b-a50b6723701b
Tischkowitz, Marc D.
26d4f395-beb7-41d7-89d5-d3430c9de0cf
Spurdle, Amanda B.
8158d468-cc96-4e39-9bac-fcaaa7061a72
Neuhausen, Susan L.
7cb359d3-5964-460c-ad60-63b77368c042
Ding, Yuan Chun
107aa0a1-2546-46b0-a1e5-a9d6dcb26744
Lindor, Noralane M.
95f60dee-421b-4055-a396-a3b05371762f
Fredericksen, Zachary
77db03d0-8de3-49c7-9a20-c9d6f84027a0
Pankratz, V. Shane
bd3ea90e-e906-41ed-846b-d012c6c30610
Peterlongo, Paolo
af3f3db4-e3fc-45db-bbb4-91954fe857fb
Manoukian, Siranoush
87f7b60d-b65f-4655-b1d8-3b7c5dcf37d2
Peissel, Bernard
94da3e26-04ab-4665-905a-aa21969c7a94
Zaffaroni, Daniela
f88dddd8-5392-415d-bbbb-c3d8e146ecb0
Barile, Monica
6cf202cf-6024-4f42-b74c-d807c79632a7
Bernard, Loris
0a345750-134d-4b15-84a6-0c7ba05efe9b
Viel, Alessandra
1d927ea7-bf84-419a-aff1-6d65b67c1280
Giannini, Giuseppe
23e46760-a759-4bd8-8096-550a02b87e43
Varesco, Liliana
07ebbeb9-3165-4a50-a227-d0896d53e86e
Radice, Paolo
d5bff2d9-ed03-4a8e-a9ca-f896a1666e2c
Greene, Mark H.
aefbcd26-0def-47a3-8580-0c56feb03756
Mai, Phuong L.
31cb800d-d6a7-4aa0-b590-4e8668ce303a
Easton, Douglas F.
2661cf5e-8fc6-4f1d-b27a-e60cac8c8819
Chenevix-Trench, Georgia
7d222914-c6e5-47b8-9022-5874b7c82a3e
Offit, Kenneth
ce1fc8a6-b5ac-434a-9d2d-4a7e1ee7ca7c
Simard, Jacques
6269fd00-31ae-40f0-b016-5f60cb9f5b96

Couch, Fergus J., Gaudet, Mia M., Antoniou, Antonis C., Ramus, Susan J., Kuchenbaecker, Karoline B., Soucy, Penny, Beesley, Jonathan, Chen, Xiaoqing, Wang, Xianshu, Kirchhoff, Tomas, McGuffog, Lesley, Barrowdale, Daniel, Lee, Andrew, Healey, Sue, Sinilnikova, Olga M., Andrulis, Irene L., Ozcelik, Hilmi, Mulligan, Anna Marie, Thomassen, Mads, Gerdes, Anne-Marie, Jensen, Uffe Birk, Skytte, Anne-Bine, Kruse, Torben A., Caligo, Maria A., von Wachenfeldt, Anna, Barbany-Bustinza, Gisela, Loman, Niklas, Soller, Maria, Ehrencrona, Hans, Karlsson, Per, Nathanson, Katherine L., Rebbeck, Timothy R., Domchek, Susan M., Jakubowska, Ania, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Zlowocka, Elżbieta, Huzarski, Tomasz, Byrski, Tomasz, Gronwald, Jacek, Cybulski, Cezary, Gorski, Bohdan, Osorio, Ana, Duran, Mercedes, Tejada, María Isabel, Benitez, Javier, Hamann, Ute, Hogervorst, Frans B.L., van Os, Theo A., van Leeuwen, Flora E., Meijers-Heijboer, Hanne E.J., Wijnen, Juul, Blok, Marinus J., Kets, Marleen, Hooning, Maartje J., Oldenburg, Rogier A., Ausems, Margreet G.E.M., Peock, Susan, Frost, Debra, Ellis, Steve D., Platte, Radka, Fineberg, Elena, Evans, D. Gareth, Jacobs, Chris, Eeles, Rosalind A., Adlard, Julian, Davidson, Rosemarie, Eccles, Diana M., Cole, Trevor, Cook, Jackie, Paterson, Joan, Brewer, Carole, Douglas, Fiona, Hodgson, Shirley V., Morrison, Patrick J., Walker, Lisa, Porteous, Mary E., Kennedy, M. John, Side, Lucy E., Bove, Betsy, Godwin, Andrew K., Stoppa-Lyonnet, Dominique, Fassy-Colcombet, Marion, Castera, Laurent, Cornelis, François, Mazoyer, Sylvie, Leone, Mélanie, Boutry-Kryza, Nadia, Bressac-de Paillerets, Brigitte, Caron, Olivier, Pujol, Pascal, Coupier, Isabelle, Delnatte, Capuchine, Akloul, Linda, Lynch, Henry T., Snyder, Carrie L., Buys, Saundra S., Daly, Mary B., Terry, MaryBeth, Chung, Wendy K., John, Esther M., Miron, Alexander, Southey, Melissa C., Hopper, John L., Goldgar, David E., Singer, Christian F., Rappaport, Christine, Tea, Muy-Kheng M., Fink-Retter, Anneliese, Hansen, Thomas V.O., Nielsen, Finn C., Arason, Aðalgeir, Vijai, Joseph, Shah, Sohela, Sarrel, Kara, Robson, Mark E., Piedmonte, Marion, Phillips, Kelly, Basil, Jack, Rubinstein, Wendy S., Boggess, John, Wakeley, Katie, Ewart-Toland, Amanda, Montagna, Marco, Agata, Simona, Imyanitov, Evgeny N., Isaacs, Claudine, Janavicius, Ramunas, Lazaro, Conxi, Blanco, Ignacio, Feliubadalo, Lidia, Brunet, Joan, Gayther, Simon A., Pharoah, Paul P.D., Odunsi, Kunle O., Karlan, Beth Y., Walsh, Christine S., Olah, Edith, Teo, Soo Hwang, Ganz, Patricia A., Beattie, Mary S., van Rensburg, Elizabeth J., Dorfling, Cecelia M., Diez, Orland, Kwong, Ava, Schmutzler, Rita K., Wappenschmidt, Barbara, Engel, Christoph, Meindl, Alfons, Ditsch, Nina, Arnold, Norbert, Heidemann, Simone, Niederacher, Dieter, Preisler-Adams, Sabine, Gadzicki, Dorothea, Varon-Mateeva, Raymonda, Deissler, Helmut, Gehrig, Andrea, Sutter, Christian, Kast, Karin, Fiebig, Britta, Heinritz, Wolfram, Caldes, Trinidad, de la Hoya, Miguel, Muranen, Tara A., Nevanlinna, Heli, Tischkowitz, Marc D., Spurdle, Amanda B., Neuhausen, Susan L., Ding, Yuan Chun, Lindor, Noralane M., Fredericksen, Zachary, Pankratz, V. Shane, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Barile, Monica, Bernard, Loris, Viel, Alessandra, Giannini, Giuseppe, Varesco, Liliana, Radice, Paolo, Greene, Mark H., Mai, Phuong L., Easton, Douglas F., Chenevix-Trench, Georgia, Offit, Kenneth and Simard, Jacques (2012) Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention, 21 (4), 645-657. (doi:10.1158/1055-9965.EPI-11-0888). (PMID:22351618)

Record type: Article

Abstract

Background: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

Methods: Genotyping data for 12,599 BRCA1 and 7,132 BRCA2 mutation carriers from 40 studies were combined.

Results: We confirmed associations between rs8170 at 19p13.1 and breast cancer risk for BRCA1 mutation carriers [HR, 1.17; 95% confidence interval (CI), 1.07-1.27; P = 7.42 × 10(-4)] and between rs16917302 at ZNF365 (HR, 0.84; 95% CI, 0.73-0.97; P = 0.017) but not rs311499 at 20q13.3 (HR, 1.11; 95% CI, 0.94-1.31; P = 0.22) and breast cancer risk for BRCA2 mutation carriers. Analyses based on tumor histopathology showed that 19p13 variants were predominantly associated with estrogen receptor (ER)-negative breast cancer for both BRCA1 and BRCA2 mutation carriers, whereas rs16917302 at ZNF365 was mainly associated with ER-positive breast cancer for both BRCA1 and BRCA2 mutation carriers. We also found for the first time that rs67397200 at 19p13.1 was associated with an increased risk of ovarian cancer for BRCA1 (HR, 1.16; 95% CI, 1.05-1.29; P = 3.8 × 10(-4)) and BRCA2 mutation carriers (HR, 1.30; 95% CI, 1.10-1.52; P = 1.8 × 10(-3)).

Conclusions: 19p13.1 and ZNF365 are susceptibility loci for ovarian cancer and ER subtypes of breast cancer among BRCA1 and BRCA2 mutation carriers.

Impact: These findings can lead to an improved understanding of tumor development and may prove useful for breast and ovarian cancer risk prediction for BRCA1 and BRCA2 mutation carriers.

Full text not available from this repository.

More information

e-pub ahead of print date: 20 February 2012
Published date: April 2012
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 352328
URI: https://eprints.soton.ac.uk/id/eprint/352328
ISSN: 1055-9965
PURE UUID: d7b2ebc8-ecbf-455c-8e1d-fb9e6e95c733

Catalogue record

Date deposited: 10 May 2013 08:58
Last modified: 16 Jul 2019 21:34

Export record

Altmetrics

Contributors

Author: Fergus J. Couch
Author: Mia M. Gaudet
Author: Antonis C. Antoniou
Author: Susan J. Ramus
Author: Karoline B. Kuchenbaecker
Author: Penny Soucy
Author: Jonathan Beesley
Author: Xiaoqing Chen
Author: Xianshu Wang
Author: Tomas Kirchhoff
Author: Lesley McGuffog
Author: Daniel Barrowdale
Author: Andrew Lee
Author: Sue Healey
Author: Olga M. Sinilnikova
Author: Irene L. Andrulis
Author: Hilmi Ozcelik
Author: Anna Marie Mulligan
Author: Mads Thomassen
Author: Anne-Marie Gerdes
Author: Uffe Birk Jensen
Author: Anne-Bine Skytte
Author: Torben A. Kruse
Author: Maria A. Caligo
Author: Anna von Wachenfeldt
Author: Gisela Barbany-Bustinza
Author: Niklas Loman
Author: Maria Soller
Author: Hans Ehrencrona
Author: Per Karlsson
Author: Katherine L. Nathanson
Author: Timothy R. Rebbeck
Author: Susan M. Domchek
Author: Ania Jakubowska
Author: Jan Lubinski
Author: Katarzyna Jaworska
Author: Katarzyna Durda
Author: Elżbieta Zlowocka
Author: Tomasz Huzarski
Author: Tomasz Byrski
Author: Jacek Gronwald
Author: Cezary Cybulski
Author: Bohdan Gorski
Author: Ana Osorio
Author: Mercedes Duran
Author: María Isabel Tejada
Author: Javier Benitez
Author: Ute Hamann
Author: Frans B.L. Hogervorst
Author: Theo A. van Os
Author: Flora E. van Leeuwen
Author: Hanne E.J. Meijers-Heijboer
Author: Juul Wijnen
Author: Marinus J. Blok
Author: Marleen Kets
Author: Maartje J. Hooning
Author: Rogier A. Oldenburg
Author: Margreet G.E.M. Ausems
Author: Susan Peock
Author: Debra Frost
Author: Steve D. Ellis
Author: Radka Platte
Author: Elena Fineberg
Author: D. Gareth Evans
Author: Chris Jacobs
Author: Rosalind A. Eeles
Author: Julian Adlard
Author: Rosemarie Davidson
Author: Diana M. Eccles
Author: Trevor Cole
Author: Jackie Cook
Author: Joan Paterson
Author: Carole Brewer
Author: Fiona Douglas
Author: Shirley V. Hodgson
Author: Patrick J. Morrison
Author: Lisa Walker
Author: Mary E. Porteous
Author: M. John Kennedy
Author: Lucy E. Side
Author: Betsy Bove
Author: Andrew K. Godwin
Author: Dominique Stoppa-Lyonnet
Author: Marion Fassy-Colcombet
Author: Laurent Castera
Author: François Cornelis
Author: Sylvie Mazoyer
Author: Mélanie Leone
Author: Nadia Boutry-Kryza
Author: Brigitte Bressac-de Paillerets
Author: Olivier Caron
Author: Pascal Pujol
Author: Isabelle Coupier
Author: Capuchine Delnatte
Author: Linda Akloul
Author: Henry T. Lynch
Author: Carrie L. Snyder
Author: Saundra S. Buys
Author: Mary B. Daly
Author: MaryBeth Terry
Author: Wendy K. Chung
Author: Esther M. John
Author: Alexander Miron
Author: Melissa C. Southey
Author: John L. Hopper
Author: David E. Goldgar
Author: Christian F. Singer
Author: Christine Rappaport
Author: Muy-Kheng M. Tea
Author: Anneliese Fink-Retter
Author: Thomas V.O. Hansen
Author: Finn C. Nielsen
Author: Aðalgeir Arason
Author: Joseph Vijai
Author: Sohela Shah
Author: Kara Sarrel
Author: Mark E. Robson
Author: Marion Piedmonte
Author: Kelly Phillips
Author: Jack Basil
Author: Wendy S. Rubinstein
Author: John Boggess
Author: Katie Wakeley
Author: Amanda Ewart-Toland
Author: Marco Montagna
Author: Simona Agata
Author: Evgeny N. Imyanitov
Author: Claudine Isaacs
Author: Ramunas Janavicius
Author: Conxi Lazaro
Author: Ignacio Blanco
Author: Lidia Feliubadalo
Author: Joan Brunet
Author: Simon A. Gayther
Author: Paul P.D. Pharoah
Author: Kunle O. Odunsi
Author: Beth Y. Karlan
Author: Christine S. Walsh
Author: Edith Olah
Author: Soo Hwang Teo
Author: Patricia A. Ganz
Author: Mary S. Beattie
Author: Elizabeth J. van Rensburg
Author: Cecelia M. Dorfling
Author: Orland Diez
Author: Ava Kwong
Author: Rita K. Schmutzler
Author: Barbara Wappenschmidt
Author: Christoph Engel
Author: Alfons Meindl
Author: Nina Ditsch
Author: Norbert Arnold
Author: Simone Heidemann
Author: Dieter Niederacher
Author: Sabine Preisler-Adams
Author: Dorothea Gadzicki
Author: Raymonda Varon-Mateeva
Author: Helmut Deissler
Author: Andrea Gehrig
Author: Christian Sutter
Author: Karin Kast
Author: Britta Fiebig
Author: Wolfram Heinritz
Author: Trinidad Caldes
Author: Miguel de la Hoya
Author: Tara A. Muranen
Author: Heli Nevanlinna
Author: Marc D. Tischkowitz
Author: Amanda B. Spurdle
Author: Susan L. Neuhausen
Author: Yuan Chun Ding
Author: Noralane M. Lindor
Author: Zachary Fredericksen
Author: V. Shane Pankratz
Author: Paolo Peterlongo
Author: Siranoush Manoukian
Author: Bernard Peissel
Author: Daniela Zaffaroni
Author: Monica Barile
Author: Loris Bernard
Author: Alessandra Viel
Author: Giuseppe Giannini
Author: Liliana Varesco
Author: Paolo Radice
Author: Mark H. Greene
Author: Phuong L. Mai
Author: Douglas F. Easton
Author: Georgia Chenevix-Trench
Author: Kenneth Offit
Author: Jacques Simard

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×