Evidence for centriolar satellite localization of CDK1 and cyclin B2
Evidence for centriolar satellite localization of CDK1 and cyclin B2
Centriolar satellites are 70-100 nm non-membranous particles implicated in the trafficking and folding of many centrosomal proteins, including the products of several disease genes. Centriolar satellites are often focused around the centrosome in interphase and either scattered throughout the cell or mostly undetectable in mitosis. The molecular mechanism underlying their disassembly/dispersal in mitosis remains unknown. Here, we present immunofluorescence microscopy data suggesting that CDK1 and cyclin B2 localise to centriolar satellites. These findings support recent biochemical data suggesting that a major component of centriolar satellites (PCM1) is a CDK1 substrate, and thus point to a role for this kinase in promoting disassembly of centriolar satellites in mitosis.
1802-1803
Spalluto, Cosma
6802ad50-bc38-404f-9a19-40916425183b
Wilson, David I.
1500fca1-7082-4271-95f4-691f1d1252a2
Hearn, Tom
2665cc10-6632-47cb-9460-bd0ea745380e
1 June 2013
Spalluto, Cosma
6802ad50-bc38-404f-9a19-40916425183b
Wilson, David I.
1500fca1-7082-4271-95f4-691f1d1252a2
Hearn, Tom
2665cc10-6632-47cb-9460-bd0ea745380e
Spalluto, Cosma, Wilson, David I. and Hearn, Tom
(2013)
Evidence for centriolar satellite localization of CDK1 and cyclin B2.
Cell Cycle, 12 (11), .
(PMID:23656781)
Abstract
Centriolar satellites are 70-100 nm non-membranous particles implicated in the trafficking and folding of many centrosomal proteins, including the products of several disease genes. Centriolar satellites are often focused around the centrosome in interphase and either scattered throughout the cell or mostly undetectable in mitosis. The molecular mechanism underlying their disassembly/dispersal in mitosis remains unknown. Here, we present immunofluorescence microscopy data suggesting that CDK1 and cyclin B2 localise to centriolar satellites. These findings support recent biochemical data suggesting that a major component of centriolar satellites (PCM1) is a CDK1 substrate, and thus point to a role for this kinase in promoting disassembly of centriolar satellites in mitosis.
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e-pub ahead of print date: 2 May 2013
Published date: 1 June 2013
Organisations:
Human Development & Health, Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 352362
URI: http://eprints.soton.ac.uk/id/eprint/352362
ISSN: 1538-4101
PURE UUID: 775c3455-53c8-4780-8524-f0a410576596
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Date deposited: 13 May 2013 10:31
Last modified: 14 Mar 2023 02:38
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Contributors
Author:
Cosma Spalluto
Author:
Tom Hearn
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