The University of Southampton
University of Southampton Institutional Repository

Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors

Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors
Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors
A series of ferrocene analogues based on a 6,7-dimethoxy-N-phenylquinazolin-4-amine template has been synthesized, and two compounds were characterized in the solid state by X-ray crystallography. The compounds have been tested for in vitro anticancer activity, against epidermal growth receptor (EGFR), and submicromolar IC50 values have been determined.
HISTONE DEACETYLASE INHIBITORS, TYROSINE KINASE, ORGANOMETALLIC COMPOUNDS, BIOLOGICAL-ACTIVITY, DRUG, ACTIVATION, REDUCTION, MECHANISM, COMPLEX, PROTEIN
0276-7333
509-513
Amin, Jahangir
15a45a7a-1741-45fa-9f31-9aa6ef1924ed
Chuckowree, Irina
7f668f7d-61e0-463a-b51a-896ed4c573eb
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Wang, Minghua
68242ec4-8322-4bb5-8386-a9326f18d074
Bingham, John P.
e41604b8-44ec-4705-8c25-00bd5bc11827
Hartley, John A.
17407879-36ee-462f-bb21-4e912619cfa0
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4
Amin, Jahangir
15a45a7a-1741-45fa-9f31-9aa6ef1924ed
Chuckowree, Irina
7f668f7d-61e0-463a-b51a-896ed4c573eb
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Wang, Minghua
68242ec4-8322-4bb5-8386-a9326f18d074
Bingham, John P.
e41604b8-44ec-4705-8c25-00bd5bc11827
Hartley, John A.
17407879-36ee-462f-bb21-4e912619cfa0
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4

Amin, Jahangir, Chuckowree, Irina, Tizzard, Graham J., Coles, Simon J., Wang, Minghua, Bingham, John P., Hartley, John A. and Spencer, John (2013) Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors. Organometallics, 32 (2), 509-513. (doi:10.1021/om300974d).

Record type: Article

Abstract

A series of ferrocene analogues based on a 6,7-dimethoxy-N-phenylquinazolin-4-amine template has been synthesized, and two compounds were characterized in the solid state by X-ray crystallography. The compounds have been tested for in vitro anticancer activity, against epidermal growth receptor (EGFR), and submicromolar IC50 values have been determined.

Full text not available from this repository.

More information

Published date: 28 January 2013
Keywords: HISTONE DEACETYLASE INHIBITORS, TYROSINE KINASE, ORGANOMETALLIC COMPOUNDS, BIOLOGICAL-ACTIVITY, DRUG, ACTIVATION, REDUCTION, MECHANISM, COMPLEX, PROTEIN
Organisations: Faculty of Natural and Environmental Sciences, Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry

Identifiers

Local EPrints ID: 352369
URI: http://eprints.soton.ac.uk/id/eprint/352369
ISSN: 0276-7333
PURE UUID: b3a8f7df-6aac-490c-96eb-c451dc876929
ORCID for Graham J. Tizzard: ORCID iD orcid.org/0000-0002-1577-5779
ORCID for Simon J. Coles: ORCID iD orcid.org/0000-0001-8414-9272

Catalogue record

Date deposited: 13 May 2013 10:48
Last modified: 18 Feb 2021 16:57

Export record

Altmetrics

Contributors

Author: Jahangir Amin
Author: Irina Chuckowree
Author: Simon J. Coles ORCID iD
Author: Minghua Wang
Author: John P. Bingham
Author: John A. Hartley
Author: John Spencer

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×