Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors
Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors
A series of ferrocene analogues based on a 6,7-dimethoxy-N-phenylquinazolin-4-amine template has been synthesized, and two compounds were characterized in the solid state by X-ray crystallography. The compounds have been tested for in vitro anticancer activity, against epidermal growth receptor (EGFR), and submicromolar IC50 values have been determined.
HISTONE DEACETYLASE INHIBITORS, TYROSINE KINASE, ORGANOMETALLIC COMPOUNDS, BIOLOGICAL-ACTIVITY, DRUG, ACTIVATION, REDUCTION, MECHANISM, COMPLEX, PROTEIN
509-513
Amin, Jahangir
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Chuckowree, Irina
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Tizzard, Graham J.
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Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Wang, Minghua
68242ec4-8322-4bb5-8386-a9326f18d074
Bingham, John P.
e41604b8-44ec-4705-8c25-00bd5bc11827
Hartley, John A.
17407879-36ee-462f-bb21-4e912619cfa0
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4
28 January 2013
Amin, Jahangir
15a45a7a-1741-45fa-9f31-9aa6ef1924ed
Chuckowree, Irina
7f668f7d-61e0-463a-b51a-896ed4c573eb
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Wang, Minghua
68242ec4-8322-4bb5-8386-a9326f18d074
Bingham, John P.
e41604b8-44ec-4705-8c25-00bd5bc11827
Hartley, John A.
17407879-36ee-462f-bb21-4e912619cfa0
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4
Amin, Jahangir, Chuckowree, Irina, Tizzard, Graham J., Coles, Simon J., Wang, Minghua, Bingham, John P., Hartley, John A. and Spencer, John
(2013)
Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors.
Organometallics, 32 (2), .
(doi:10.1021/om300974d).
Abstract
A series of ferrocene analogues based on a 6,7-dimethoxy-N-phenylquinazolin-4-amine template has been synthesized, and two compounds were characterized in the solid state by X-ray crystallography. The compounds have been tested for in vitro anticancer activity, against epidermal growth receptor (EGFR), and submicromolar IC50 values have been determined.
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Published date: 28 January 2013
Keywords:
HISTONE DEACETYLASE INHIBITORS, TYROSINE KINASE, ORGANOMETALLIC COMPOUNDS, BIOLOGICAL-ACTIVITY, DRUG, ACTIVATION, REDUCTION, MECHANISM, COMPLEX, PROTEIN
Organisations:
Faculty of Natural and Environmental Sciences, Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry
Identifiers
Local EPrints ID: 352369
URI: http://eprints.soton.ac.uk/id/eprint/352369
ISSN: 0276-7333
PURE UUID: b3a8f7df-6aac-490c-96eb-c451dc876929
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Date deposited: 13 May 2013 10:48
Last modified: 15 Mar 2024 03:10
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Contributors
Author:
Jahangir Amin
Author:
Irina Chuckowree
Author:
Minghua Wang
Author:
John P. Bingham
Author:
John A. Hartley
Author:
John Spencer
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