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The intrauterine origins of Hodgkin's lymphoma

The intrauterine origins of Hodgkin's lymphoma
The intrauterine origins of Hodgkin's lymphoma
Background: Both small and large body size at birth are now known to predict a range of chronic disorders in adult life, including certain cancers. These associations are thought to reflect "fetal programming." This may lead to impairment of a small number of key systems including the immune system. Hodgkin's lymphoma is a disease of the immune system. We have therefore examined the association between Hodgkin's lymphoma and early development. Our hypothesis was that the disease would be associated with markers of poor fetal growth, specifically small body size or small placental size at birth.

Methods: Using the Finnish Cancer Registry we identified patients with Hodgkin's disease in a cohort of 20,431 people born in Helsinki during 1924-44. Each person has a detailed birth record.

Results: There were 12 patients with Hodgkin's disease, giving an incidence comparable to international rates. The disease was associated with prolonged gestation. For every additional week of gestation the hazard ratio was 1.37 (95% CI 1.00-1.87; p=0.05). The disease was also associated with a short placental surface. After allowing for gestation, for each centimetre increase in surface length, the hazard ratio was 0.70 (0.53-0.92; p=0.01). The disease was not associated with birth weight or length or maternal body size.

Conclusions: We have shown that Hodgkin's lymphoma is associated with prolonged gestation and a short length of the placental surface. We speculate that Hodgkin's lymphoma is initiated by two events in fetal life. One, which is an immune event, is associated with prolonged gestation, while the other is associated with growth faltering.
1877-7821
321-323
Barker, D.J.
2677bf85-494f-4a78-adf8-580e1b8acb81
Thornburg, Kent L.
49e1e87d-82d6-41f3-894e-ece7a5a19651
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Eriksson, Johan G.
e95e6451-67bb-4338-803e-7af310a920ac
Barker, D.J.
2677bf85-494f-4a78-adf8-580e1b8acb81
Thornburg, Kent L.
49e1e87d-82d6-41f3-894e-ece7a5a19651
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Eriksson, Johan G.
e95e6451-67bb-4338-803e-7af310a920ac

Barker, D.J., Thornburg, Kent L., Kajantie, Eero and Eriksson, Johan G. (2013) The intrauterine origins of Hodgkin's lymphoma. Cancer Epidemiology, 37 (3), 321-323. (doi:10.1016/j.canep.2013.01.004). (PMID:23403130)

Record type: Article

Abstract

Background: Both small and large body size at birth are now known to predict a range of chronic disorders in adult life, including certain cancers. These associations are thought to reflect "fetal programming." This may lead to impairment of a small number of key systems including the immune system. Hodgkin's lymphoma is a disease of the immune system. We have therefore examined the association between Hodgkin's lymphoma and early development. Our hypothesis was that the disease would be associated with markers of poor fetal growth, specifically small body size or small placental size at birth.

Methods: Using the Finnish Cancer Registry we identified patients with Hodgkin's disease in a cohort of 20,431 people born in Helsinki during 1924-44. Each person has a detailed birth record.

Results: There were 12 patients with Hodgkin's disease, giving an incidence comparable to international rates. The disease was associated with prolonged gestation. For every additional week of gestation the hazard ratio was 1.37 (95% CI 1.00-1.87; p=0.05). The disease was also associated with a short placental surface. After allowing for gestation, for each centimetre increase in surface length, the hazard ratio was 0.70 (0.53-0.92; p=0.01). The disease was not associated with birth weight or length or maternal body size.

Conclusions: We have shown that Hodgkin's lymphoma is associated with prolonged gestation and a short length of the placental surface. We speculate that Hodgkin's lymphoma is initiated by two events in fetal life. One, which is an immune event, is associated with prolonged gestation, while the other is associated with growth faltering.

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Published date: 31 January 2013
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 352410
URI: https://eprints.soton.ac.uk/id/eprint/352410
ISSN: 1877-7821
PURE UUID: 9f8c737f-87e3-40b0-a6cb-f9e59fbb8599
ORCID for D.J. Barker: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 13 May 2013 12:11
Last modified: 06 Jun 2018 13:04

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Author: D.J. Barker ORCID iD
Author: Kent L. Thornburg
Author: Eero Kajantie
Author: Johan G. Eriksson

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