Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer susceptibility variants have been shown to be associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, the involvement of these SNPs to breast cancer susceptibility in mutation carriers is currently unknown. To address this, we genotyped these SNPs in BRCA1 and BRCA2 mutation carriers from 42 studies from the Consortium of Investigators of Modifiers of BRCA1/2. In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r2 = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11–1.23, P-trend = 4.5 × 10?9 for rs2046210; HR = 1.28, 95% CI: 1.18–1.40, P-trend = 1.3 × 10?8 for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01–1.28, P-trend = 0.031). SNP rs11249433 (1p11.2) was associated with the risk of breast cancer for BRCA2 mutation carriers (HR = 1.09, 95% CI: 1.02–1.17, P-trend = 0.015), but was not associated with breast cancer risk for BRCA1 mutation carriers (HR = 0.97, 95% CI: 0.92–1.02, P-trend = 0.20). SNP rs999737 (RAD51L1) was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers (P-trend = 0.27 and 0.30, respectively). The identification of SNPs at 6q25.1 associated with breast cancer risk for BRCA1 mutation carriers will lead to a better understanding of the biology of tumour development in these women.
3304-3321
Antoniou, A.C.
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Kartsonaki, C.
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Sinilnikova, O.M.
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Soucy, P.
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McGuffog, L.
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Healey, S.
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Lee, A.
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Peterlongo, P.
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Manoukian, S.
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Peissel, B.
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Barile, M.
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Pensotti, V.
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Pasini, B.
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Dolcetti, R.
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Giannini, G.
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Laura Putignano, A.
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Varesco, L.
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Greene, M.H.
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Andrulis, I.L.
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Glendon, G.
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Ozcelik, H.
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Gerdes, A.-M.
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Laitman, Y.
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Milgrom, R.
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Kaufman, B.
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Loman, N.
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Lindblom, A.
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Arver, B.
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Ehrencrona, H.
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Melin, B.
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Nathanson, K.L.
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Domchek, S.M.
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Rebbeck, T.
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Jakubowska, A.
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Lubinski, J.
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Gronwald, J.
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Huzarski, T.
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Byrski, T.
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Cybulski, C.
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Gorski, B.
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Osorio, A.
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Ramon y Cajal, T.
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Fostira, F.
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Andres, R.
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Benitez, J.
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Hamann, U.
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Hogervorst, F.B.
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Rookus, M.A.
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Hooning, M.J.
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Nelen, M.R.
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van der Luijt, R.B.
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van Os, T.A.M.
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van Asperen, C.J.
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Devilee, P.
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Meijers-Heijboer, H.E.J.
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Gomez Garcia, E.B.
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Peock, S.
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Cook, M.
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Frost, D.
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Platte, R.
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Leyland, J.
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Gareth Evans, D.
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Lalloo, F.
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Eeles, R.
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Izatt, L.
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Adlard, J.
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Davidson, R.
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Eccles, D.
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Ong, K.-r.
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Cook, J.
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Douglas, F.
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Paterson, J.
b6d85117-51f3-4ba4-b105-6c3c304a1805
John Kennedy, M.
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Miedzybrodzka, Z.
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Godwin, A.
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Stoppa-Lyonnet, D.
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Buecher, B.
799b353c-c523-4c0a-acdb-ea71a46f9a26
Belotti, M.
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Tirapo, C.
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Mazoyer, S.
b9994392-3dbd-420d-8aa3-f2032c7938b8
Barjhoux, L.
2e26adfc-7c40-4572-9797-0a7cbf3167c4
Lasset, C.
81438d0e-80af-4224-ba95-400e31934ff0
Leroux, D.
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Faivre, L.
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Bronner, M.
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Prieur, F.
b4e2ee8e-9e38-4497-b89a-0312f729c952
Nogues, C.
0142dd14-d46c-48c2-b2da-7ce12029c472
Rouleau, E.
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Pujol, P.
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Coupier, I.
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Frenay, M.
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Hopper, J.L.
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Daly, M.B.
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Terry, M.B.
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John, E.M.
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Buys, S.S.
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Yassin, Y.
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Miron, A.
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Goldgar, D.
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Singer, C.F.
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Tea, M.-K.
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Pfeiler, G.
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Catharina Dressler, A.
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Hansen, T.v.O.
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Jonson, L.
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Ejlertsen, B.
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Bjork Barkardottir, R.
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Kirchhoff, T.
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Offit, K.
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Piedmonte, M.
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Rodriguez, G.
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Small, L.
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Boggess, J.
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Blank, S.
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Basil, J.
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Azodi, M.
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Ewart Toland, A.
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Montagna, M.
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Tognazzo, S.
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Agata, S.
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Imyanitov, E.
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Janavicius, R.
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Lazaro, C.
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Blanco, I.
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Pharoah, P.D.P.
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Sucheston, L.
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Karlan, B.Y.
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Walsh, C.S.
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Olah, E.
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Bozsik, A.
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Teo, S.-H.
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Seldon, J.L.
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Beattie, M.S.
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van Rensburg, E.J.
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Sluiter, M.D.
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Diez, O.
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Schmutzler, R.K.
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Wappenschmidt, B.
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Engel, C.
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Meindl, A.
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Ruehl, I.
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Varon-Mateeva, R.
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Kast, K.
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Deissler, H.
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Niederacher, D.
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Arnold, N.
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Gadzicki, D.
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Schonbuchner, I.
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Caldes, T.
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de la Hoya, M.
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Nevanlinna, H.
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Aittomaki, K.
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Dumont, M.
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Chiquette, J.
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Tischkowitz, M.
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Chen, X.
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Beesley, J.
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Spurdle, A.B.
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Neuhausen, S.L.
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Chun Ding, Y.
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Fredericksen, Z.
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Wang, X.
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Pankratz, V.S.
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Couch, F.
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Simard, J.
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Easton, D.F.
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Chenevix-Trench, G.
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15 August 2011
Antoniou, A.C.
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Kartsonaki, C.
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Sinilnikova, O.M.
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Soucy, P.
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McGuffog, L.
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Healey, S.
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Lee, A.
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Peterlongo, P.
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Manoukian, S.
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Peissel, B.
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Zaffaroni, D.
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Cattaneo, E.
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Barile, M.
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Pensotti, V.
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Pasini, B.
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Dolcetti, R.
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Giannini, G.
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Laura Putignano, A.
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Varesco, L.
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Radice, P.
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Mai, P.L.
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Greene, M.H.
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Andrulis, I.L.
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Glendon, G.
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Ozcelik, H.
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Gerdes, A.-M.
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Kruse, T.A.
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Cruger, D.G.
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Caligo, M.A.
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Laitman, Y.
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Milgrom, R.
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Kaufman, B.
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Paluch-Shimon, S.
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Friedman, E.
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Loman, N.
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Harbst, K.
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Lindblom, A.
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Nathanson, K.L.
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Jakubowska, A.
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Gronwald, J.
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Huzarski, T.
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Byrski, T.
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Cybulski, C.
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Gorski, B.
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Osorio, A.
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Ramon y Cajal, T.
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Andres, R.
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Benitez, J.
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Hamann, U.
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Hogervorst, F.B.
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Rookus, M.A.
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Hooning, M.J.
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van der Luijt, R.B.
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van Os, T.A.M.
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van Asperen, C.J.
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Devilee, P.
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Meijers-Heijboer, H.E.J.
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Gomez Garcia, E.B.
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Peock, S.
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Cook, M.
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Frost, D.
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Platte, R.
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Leyland, J.
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Gareth Evans, D.
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Lalloo, F.
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Eeles, R.
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Izatt, L.
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Adlard, J.
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Davidson, R.
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Eccles, D.
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Ong, K.-r.
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Cook, J.
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Douglas, F.
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Paterson, J.
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John Kennedy, M.
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Miedzybrodzka, Z.
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Godwin, A.
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Buecher, B.
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Belotti, M.
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Tirapo, C.
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Mazoyer, S.
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Barjhoux, L.
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Lasset, C.
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Leroux, D.
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Faivre, L.
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Bronner, M.
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Prieur, F.
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Nogues, C.
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Rouleau, E.
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Pujol, P.
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Coupier, I.
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Hopper, J.L.
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Daly, M.B.
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Buys, S.S.
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Yassin, Y.
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Miron, A.
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Goldgar, D.
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Singer, C.F.
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Tea, M.-K.
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Pfeiler, G.
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Catharina Dressler, A.
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Hansen, T.v.O.
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Jonson, L.
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Ejlertsen, B.
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Bjork Barkardottir, R.
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Kirchhoff, T.
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Piedmonte, M.
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Rodriguez, G.
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Small, L.
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Boggess, J.
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Blank, S.
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Basil, J.
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Azodi, M.
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Ewart Toland, A.
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Montagna, M.
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Tognazzo, S.
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Agata, S.
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Imyanitov, E.
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Janavicius, R.
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Lazaro, C.
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Blanco, I.
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Pharoah, P.D.P.
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Sucheston, L.
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Karlan, B.Y.
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Walsh, C.S.
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Olah, E.
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Bozsik, A.
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Teo, S.-H.
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Seldon, J.L.
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Beattie, M.S.
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van Rensburg, E.J.
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Wappenschmidt, B.
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Engel, C.
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Meindl, A.
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Ruehl, I.
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Varon-Mateeva, R.
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Kast, K.
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Deissler, H.
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Arnold, N.
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Gadzicki, D.
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Schonbuchner, I.
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Caldes, T.
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de la Hoya, M.
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Nevanlinna, H.
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Aittomaki, K.
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Dumont, M.
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Chiquette, J.
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Chen, X.
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Beesley, J.
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Spurdle, A.B.
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Neuhausen, S.L.
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Chun Ding, Y.
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Fredericksen, Z.
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Couch, F.
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Easton, D.F.
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Chenevix-Trench, G.
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