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Common breast cancer susceptibility loci are associated with triple-negative breast cancer

Common breast cancer susceptibility loci are associated with triple-negative breast cancer
Common breast cancer susceptibility loci are associated with triple-negative breast cancer
Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.
0008-5472
6240-6249
Stevens, Kristen N.
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Stevens, Kristen N., Vachon, Celine M., Lee, Adam M., Slager, Susan, Lesnick, Timothy, Olswold, Curtis, Fasching, Peter A., Miron, Penelope, Eccles, Diana, Carpenter, Jane E., Godwin, Andrew K., Ambrosone, Christine, Winqvist, Robert, Brauch, Hiltrud, Schmidt, Marjanka K., Cox, Angela, Cross, Simon S., Sawyer, Elinor, Hartmann, Arndt, Beckmann, Matthias W., Schulz-Wendtland, Rüdiger, Ekici, Arif B., Tapper, William J., Gerty, Susan M., Durcan, Lorraine, Graham, Nikki J., Hein, Rebecca, Nickels, Stephan, Flesch-Janys, Dieter, Heinz, Judith, Sinn, Hans-Peter, Konstantopoulou, Irene, Fostira, Florentia, Pectasides, Dimitrios, Dimopoulos, Athanasios M., Fountzilas, George, Clarke, Christine L., Balleine, Rosemary, Olson, Janet E., Fredericksen, Zachary, Diasio, Robert B., Pathak, Harsh, Ross, Eric, Weaver, JoEllen, Rüdiger, Thomas, Forsti, Asta, Dünnebier, Thomas, Ademuyiwa, Foluso, Kulkarni, Swati, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Ko, Yon-Dschun, Van Limbergen, Erik, Janssen, Hilde, Peto, Julian, Fletcher, Olivia, Giles, Graham G., Baglietto, Laura, Verhoef, Senno, Tomlinson, Ian, Kosma, Veli-Matti, Beesley, Jonathan, Greco, Dario, Blomqvist, Carl, Irwanto, Astrid, Liu, Jianjun, Blows, Fiona M., Dawson, Sarah-Jane, Margolin, Sara, Mannermaa, Arto, Martin, Nicholas G., Montgomery, Grant W., Lambrechts, Diether, dos Santos Silva, Isabel, Severi, Gianluca, Hamann, Ute, Pharoah, Paul, Easton, Douglas F., Chang-Claude, Jenny, Yannoukakos, Drakoulis, Nevanlinna, Heli, Wang, Xianshu and Couch, Fergus J. (2011) Common breast cancer susceptibility loci are associated with triple-negative breast cancer. Cancer Research, 71 (19), 6240-6249. (doi:10.1158/0008-5472.CAN-11-1266). (PMID:21844186)

Record type: Article

Abstract

Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.

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More information

e-pub ahead of print date: 15 August 2011
Published date: 1 October 2011
Related URLs:
Organisations: Cancer Sciences, Human Development & Health, Clinical Trials Unit

Identifiers

Local EPrints ID: 352473
URI: http://eprints.soton.ac.uk/id/eprint/352473
DOI: doi:10.1158/0008-5472.CAN-11-1266
ISSN: 0008-5472
PURE UUID: 8d47332f-876c-4ff1-97f9-97b40af29bf6
ORCID for Diana Eccles: ORCID iD orcid.org/0000-0002-9935-3169
ORCID for William J. Tapper: ORCID iD orcid.org/0000-0002-5896-1889

Catalogue record

Date deposited: 16 May 2013 10:28
Last modified: 15 Mar 2024 03:02

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Contributors

Author: Kristen N. Stevens
Author: Celine M. Vachon
Author: Adam M. Lee
Author: Susan Slager
Author: Timothy Lesnick
Author: Curtis Olswold
Author: Peter A. Fasching
Author: Penelope Miron
Author: Diana Eccles ORCID iD
Author: Jane E. Carpenter
Author: Andrew K. Godwin
Author: Christine Ambrosone
Author: Robert Winqvist
Author: Hiltrud Brauch
Author: Marjanka K. Schmidt
Author: Angela Cox
Author: Simon S. Cross
Author: Elinor Sawyer
Author: Arndt Hartmann
Author: Matthias W. Beckmann
Author: Rüdiger Schulz-Wendtland
Author: Arif B. Ekici
Author: William J. Tapper ORCID iD
Author: Susan M. Gerty
Author: Lorraine Durcan
Author: Nikki J. Graham
Author: Rebecca Hein
Author: Stephan Nickels
Author: Dieter Flesch-Janys
Author: Judith Heinz
Author: Hans-Peter Sinn
Author: Irene Konstantopoulou
Author: Florentia Fostira
Author: Dimitrios Pectasides
Author: Athanasios M. Dimopoulos
Author: George Fountzilas
Author: Christine L. Clarke
Author: Rosemary Balleine
Author: Janet E. Olson
Author: Zachary Fredericksen
Author: Robert B. Diasio
Author: Harsh Pathak
Author: Eric Ross
Author: JoEllen Weaver
Author: Thomas Rüdiger
Author: Asta Forsti
Author: Thomas Dünnebier
Author: Foluso Ademuyiwa
Author: Swati Kulkarni
Author: Katri Pylkäs
Author: Arja Jukkola-Vuorinen
Author: Yon-Dschun Ko
Author: Erik Van Limbergen
Author: Hilde Janssen
Author: Julian Peto
Author: Olivia Fletcher
Author: Graham G. Giles
Author: Laura Baglietto
Author: Senno Verhoef
Author: Ian Tomlinson
Author: Veli-Matti Kosma
Author: Jonathan Beesley
Author: Dario Greco
Author: Carl Blomqvist
Author: Astrid Irwanto
Author: Jianjun Liu
Author: Fiona M. Blows
Author: Sarah-Jane Dawson
Author: Sara Margolin
Author: Arto Mannermaa
Author: Nicholas G. Martin
Author: Grant W. Montgomery
Author: Diether Lambrechts
Author: Isabel dos Santos Silva
Author: Gianluca Severi
Author: Ute Hamann
Author: Paul Pharoah
Author: Douglas F. Easton
Author: Jenny Chang-Claude
Author: Drakoulis Yannoukakos
Author: Heli Nevanlinna
Author: Xianshu Wang
Author: Fergus J. Couch

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