Recycling and imaging of nuclear singlet hyperpolarization
Recycling and imaging of nuclear singlet hyperpolarization
The strong enhancement of NMR signals achieved by hyperpolarization decays, at best, with a time constant of a few minutes. Here, we show that a combination of long-lived singlet states, molecular design, magnetic field cycling, and specific radiofrequency pulse sequences allows repeated observation of the same batch of polarized nuclei over a period of 30 min and more. We report a recycling protocol in which the enhanced nuclear polarization achieved by dissolution-DNP is observed with full intensity and then returned to singlet order. MRI experiments may be run on a portion of the available spin polarization, while the remaining is preserved and made available for a later use. An analogy is drawn with a “spin bank” or “resealable container” in which highly polarized spin order may be deposited and retrieved.
5084-5088
Pileio, Giuseppe
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Bowen, Sean
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Laustsen, Christoffer
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Tayler, Michael C.D.
d5cb67f4-6c82-4a25-8b2c-75a1212657ed
Hill-Cousins, Joseph T.
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Brown, Lynda J.
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Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Ardenkjaer-Larsen, Jan H.
fcc87c01-7cea-467c-917d-00fc489fa047
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
3 April 2013
Pileio, Giuseppe
13f78e66-0707-4438-b9c9-6dbd3eb7d4e8
Bowen, Sean
88b1846b-da80-4ad0-b7d1-7d9cfffeab33
Laustsen, Christoffer
bc7e127b-8cad-4593-b6f7-8233aa72ebab
Tayler, Michael C.D.
d5cb67f4-6c82-4a25-8b2c-75a1212657ed
Hill-Cousins, Joseph T.
3fd2a389-1612-4d9d-8322-afcc0c401ada
Brown, Lynda J.
75aa95fa-5d27-46a7-9dbe-0f465a664f5b
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Ardenkjaer-Larsen, Jan H.
fcc87c01-7cea-467c-917d-00fc489fa047
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Pileio, Giuseppe, Bowen, Sean, Laustsen, Christoffer, Tayler, Michael C.D., Hill-Cousins, Joseph T., Brown, Lynda J., Brown, Richard C.D., Ardenkjaer-Larsen, Jan H. and Levitt, Malcolm H.
(2013)
Recycling and imaging of nuclear singlet hyperpolarization.
Journal of the American Chemical Society, 135 (13), .
(doi:10.1021/ja312333v).
Abstract
The strong enhancement of NMR signals achieved by hyperpolarization decays, at best, with a time constant of a few minutes. Here, we show that a combination of long-lived singlet states, molecular design, magnetic field cycling, and specific radiofrequency pulse sequences allows repeated observation of the same batch of polarized nuclei over a period of 30 min and more. We report a recycling protocol in which the enhanced nuclear polarization achieved by dissolution-DNP is observed with full intensity and then returned to singlet order. MRI experiments may be run on a portion of the available spin polarization, while the remaining is preserved and made available for a later use. An analogy is drawn with a “spin bank” or “resealable container” in which highly polarized spin order may be deposited and retrieved.
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e-pub ahead of print date: 25 March 2013
Published date: 3 April 2013
Organisations:
Magnetic Resonance
Identifiers
Local EPrints ID: 352481
URI: http://eprints.soton.ac.uk/id/eprint/352481
ISSN: 0002-7863
PURE UUID: bfad6707-be71-4128-a7af-50404a4986b6
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Date deposited: 14 May 2013 13:08
Last modified: 01 May 2024 01:41
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Contributors
Author:
Sean Bowen
Author:
Christoffer Laustsen
Author:
Michael C.D. Tayler
Author:
Joseph T. Hill-Cousins
Author:
Jan H. Ardenkjaer-Larsen
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