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Recycling and imaging of nuclear singlet hyperpolarization

Recycling and imaging of nuclear singlet hyperpolarization
Recycling and imaging of nuclear singlet hyperpolarization
The strong enhancement of NMR signals achieved by hyperpolarization decays, at best, with a time constant of a few minutes. Here, we show that a combination of long-lived singlet states, molecular design, magnetic field cycling, and specific radiofrequency pulse sequences allows repeated observation of the same batch of polarized nuclei over a period of 30 min and more. We report a recycling protocol in which the enhanced nuclear polarization achieved by dissolution-DNP is observed with full intensity and then returned to singlet order. MRI experiments may be run on a portion of the available spin polarization, while the remaining is preserved and made available for a later use. An analogy is drawn with a “spin bank” or “resealable container” in which highly polarized spin order may be deposited and retrieved.
0002-7863
5084-5088
Pileio, Giuseppe
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Bowen, Sean
88b1846b-da80-4ad0-b7d1-7d9cfffeab33
Laustsen, Christoffer
bc7e127b-8cad-4593-b6f7-8233aa72ebab
Tayler, Michael C.D.
d5cb67f4-6c82-4a25-8b2c-75a1212657ed
Hill-Cousins, Joseph T.
3fd2a389-1612-4d9d-8322-afcc0c401ada
Brown, Lynda J.
75aa95fa-5d27-46a7-9dbe-0f465a664f5b
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Ardenkjaer-Larsen, Jan H.
fcc87c01-7cea-467c-917d-00fc489fa047
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Pileio, Giuseppe
13f78e66-0707-4438-b9c9-6dbd3eb7d4e8
Bowen, Sean
88b1846b-da80-4ad0-b7d1-7d9cfffeab33
Laustsen, Christoffer
bc7e127b-8cad-4593-b6f7-8233aa72ebab
Tayler, Michael C.D.
d5cb67f4-6c82-4a25-8b2c-75a1212657ed
Hill-Cousins, Joseph T.
3fd2a389-1612-4d9d-8322-afcc0c401ada
Brown, Lynda J.
75aa95fa-5d27-46a7-9dbe-0f465a664f5b
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Ardenkjaer-Larsen, Jan H.
fcc87c01-7cea-467c-917d-00fc489fa047
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3

Pileio, Giuseppe, Bowen, Sean, Laustsen, Christoffer, Tayler, Michael C.D., Hill-Cousins, Joseph T., Brown, Lynda J., Brown, Richard C.D., Ardenkjaer-Larsen, Jan H. and Levitt, Malcolm H. (2013) Recycling and imaging of nuclear singlet hyperpolarization. Journal of the American Chemical Society, 135 (13), 5084-5088. (doi:10.1021/ja312333v).

Record type: Article

Abstract

The strong enhancement of NMR signals achieved by hyperpolarization decays, at best, with a time constant of a few minutes. Here, we show that a combination of long-lived singlet states, molecular design, magnetic field cycling, and specific radiofrequency pulse sequences allows repeated observation of the same batch of polarized nuclei over a period of 30 min and more. We report a recycling protocol in which the enhanced nuclear polarization achieved by dissolution-DNP is observed with full intensity and then returned to singlet order. MRI experiments may be run on a portion of the available spin polarization, while the remaining is preserved and made available for a later use. An analogy is drawn with a “spin bank” or “resealable container” in which highly polarized spin order may be deposited and retrieved.

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Published date: 15 March 2013
Organisations: Magnetic Resonance

Identifiers

Local EPrints ID: 352481
URI: https://eprints.soton.ac.uk/id/eprint/352481
ISSN: 0002-7863
PURE UUID: bfad6707-be71-4128-a7af-50404a4986b6
ORCID for Giuseppe Pileio: ORCID iD orcid.org/0000-0001-9223-3896
ORCID for Lynda J. Brown: ORCID iD orcid.org/0000-0002-5678-0814
ORCID for Richard C.D. Brown: ORCID iD orcid.org/0000-0003-0156-7087
ORCID for Malcolm H. Levitt: ORCID iD orcid.org/0000-0001-9878-1180

Catalogue record

Date deposited: 14 May 2013 13:08
Last modified: 10 Sep 2019 00:52

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