The University of Southampton
University of Southampton Institutional Repository

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
INTRODUCTION: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour.

METHODS: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumour, to assess the associations of 12 loci with breast cancer tumour characteristics. Associations were evaluated using a retrospective cohort approach.

RESULTS: The results suggested stronger associations with ER-positive breast cancer than ER-negative for 11 loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, single nucleotide polymorphism (SNP) rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele hazard ratio (HR) for ER-positive = 1.35, 95% CI: 1.17 to 1.56 vs HR = 0.91, 95% CI: 0.85 to 0.98 for ER-negative, P-heterogeneity = 6.5 × 10-6). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and 1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status.

CONCLUSIONS: The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers.
R110
Mulligan, Anna Marie
a999fb4f-9064-4311-90fc-3e8e80a5458a
Couch, Fergus J.
778e32f1-0b19-4cf4-b38f-69dd027cad3a
Barrowdale, Daniel
507bc817-9e80-4ff2-a379-470e0d6ed2c9
Domchek, Susan M.
7d99c293-81c9-4f0e-ab2c-e2655e2b601e
Eccles, Diana
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Nevanlinna, Heli
69be7a44-2abf-4504-a47b-a50b6723701b
Ramus, Susan J.
f2a91d0b-8aab-4e57-b49f-7637767b4f57
Robson, Mark
c5e6e973-8fbe-4efd-b2b3-84c885e18b4c
Sherman, Mark
b902cc3b-75cb-42b5-a618-0390d842987c
Spurdle, Amanda B.
8158d468-cc96-4e39-9bac-fcaaa7061a72
Wappenschmidt, Barbara
b196c313-8a35-4e32-a020-10181ac41400
Lee, Andrew
a82db836-29cd-4bf5-a96a-fb6af545b310
McGuffog, Lesley
21522096-38bb-45df-aa56-caf2f27d7254
Healey, Sue
5d595192-5381-464d-85cc-71ad09a05065
Sinilnikova, Olga M.
17bb19c7-8db3-48e3-8630-0c9a78a2e1a4
Janavicius, Ramunas
314ff9ed-91c2-49cc-aa80-5ab072225a98
Hansen, Thomas vO.
61642f06-2a1e-45e3-a3ad-69309150a8d9
Nielsen, Finn C.
38defc00-22e2-4d73-9ad3-18a4115d926c
Ejlertsen, Bent
b9f56a71-7d7c-4a1d-98d2-fdd32e7a3ad7
Osorio, Ana
5d37d9d7-d889-4e14-ad7c-7b7f73f6e299
Muñoz-Repeto, Iván
465178b6-e4fb-4f8a-ba48-844c9166321d
Durán, Mercedes
5ba80f97-eeb8-452a-b589-06bfbba0088f
Godino, Javier
ace718e4-a983-49d9-ac5a-3773c1cf1979
Pertesi, Maroulio
cf1b1c3a-a9f0-49ef-9ed9-52693294aa4e
Benítez, Javier
6fa8139c-6298-4f8a-9152-de51fc294a83
Peterlongo, Paolo
af3f3db4-e3fc-45db-bbb4-91954fe857fb
Manoukian, Siranoush
87f7b60d-b65f-4655-b1d8-3b7c5dcf37d2
Peissel, Bernard
94da3e26-04ab-4665-905a-aa21969c7a94
Zaffaroni, Daniela
f88dddd8-5392-415d-bbbb-c3d8e146ecb0
Cattaneo, Elisa
1464e50c-5a43-4b8f-9ffb-272aa7aa476a
Bonanni, Bernardo
6ab53b39-2f33-42be-9c4e-eb577feb5124
Viel, Alessandra
1d927ea7-bf84-419a-aff1-6d65b67c1280
Pasini, Barbara
7731dc58-2844-4fcc-98e0-b212353037da
Papi, Laura
01bafe05-bdb9-4feb-953d-3def9b73baa8
Ottini, Laura
361443a8-6d75-4ea5-b1f8-f7a3b03f97a8
Savarese, Antonella
2777ee53-d872-4ed8-bb36-659bdb450fc8
Bernard, Loris
0a345750-134d-4b15-84a6-0c7ba05efe9b
Radice, Paolo
d5bff2d9-ed03-4a8e-a9ca-f896a1666e2c
Hamann, Ute
c47a5052-5e7b-492c-988b-38b7df2cffc6
Verheus, Martijn
1b9e09e4-c498-48b2-a746-6ab9e0649090
Meijers-Heijboer, Hanne E.J.
1662d152-1979-4cea-a8ba-49242bf0985b
Wijnen, Juul
1556ff67-a692-4d20-b2a8-d0869985558e
Gómez García, Encarna B.
bdfeeb10-870e-41e9-9141-cd36b334f92c
Nelen, Marcel R.
0ed4c29f-83a0-4c95-87e9-53184993e206
Kets, C. Marleen
062620d0-d56a-4b00-8b34-3b1e9cda85ca
Seynaeve, Caroline
1e8ad8ea-5121-4eee-88d6-45e34614f7af
Tilanus-Linthorst, Madeleine M.A.
43b9db42-f5ed-49be-bf7f-faa81240e467
van der Luijt, Rob B.
382af51c-839b-4d04-9274-34878f862fed
Os, Theo
bafeac3f-4b03-425f-a19d-9e10d7e837cf
Rookus, Matti
4a82efda-4af5-43fa-a584-91d5f8ab50d6
Frost, Debra
38874d28-24d7-47b2-b458-b121539a3ceb
Jones, J. Louise
a6a6c58f-c843-42c7-8832-7c970959610c
Evans, D. Gareth
314acefb-89fb-4eb7-a0e7-0a6949c9af6c
Lalloo, Fiona
d7ac29ee-10db-49a5-af3c-265b6d1c113d
Eeles, Ros
1101f5dc-f8ae-4102-99fb-f814695e5f9c
Izatt, Louise
5d6201a8-8a56-4923-ac9d-75dca6be0a40
Adlard, Julian
3a01574a-8ed1-4286-956c-c9e87fd89521
Davidson, Rosemarie
81692cd9-0a70-4a01-a68f-8eb623f0fbe0
Cook, Jackie
b24e3336-f47a-4590-bc3f-7e2ab7d78e0d
Donaldson, Alan
8bd5454f-be4c-4b7a-ae31-c602f391920e
Dorkins, Huw
713e497f-c4cd-4d73-a190-9d1d8bcf53b1
Gregory, Helen
d486c9b1-6c6c-4cc1-9240-9e2c7db5495e
Eason, Jacqueline
537aca11-c033-407a-920e-99b0011bea6c
Houghton, Catherine
03c28ff3-f73f-46a4-891f-b0c55ef4c1fe
Barwell, Julian
775206d7-77c1-46bb-a6ff-932204a3c2f5
Side, Lucy E.
f9e1faa2-2814-4c9e-8470-65d0f92ddcd6
McCann, Emma
e86886b8-4f81-453f-a381-41003d14d699
Murray, Alex
a720c70c-691b-4c06-843e-3c3f3c1e9963
Peock, Susan
7e420471-9ee5-4a07-9536-bfdc4c6f1297
Godwin, Andrew K.
a7e89dce-59e1-48f7-b668-42777f362435
Schmutzler, Rita K.
bf790f2e-79f3-4151-a74c-793bf14d8f6a
Rhiem, Kerstin
5fbe374e-0810-4da0-a4fa-3e311fa952d7
Engel, Christoph
e428d3b6-d668-487c-bcef-7d835e609751
Meindl, Alfons
10b41dbc-4030-4b19-976f-212367b636af
Ruehl, Ina
12a66011-501b-4ae7-b8a8-7869ed3f774d
Arnold, Norbert
2296ee7c-7ba5-48cb-8514-c0a9c4a25eb9
Niederacher, Dieter
b6a4a233-f88d-416b-a22e-9902d732d8e6
Sutter, Christian
c54383c2-0738-42cc-b0ab-c2595b4ec272
Deissler, Helmut
58cbec72-5288-4cdd-9e55-f0ca1331bb53
Gadzicki, Dorothea
b4f1469f-e0a9-4feb-b125-8f45bb99f03f
Kast, Karin
7cde00f5-f897-4c84-bb86-2ecdd6e23b6d
Preisler-Adams, Sabine
82c50384-58e6-4299-a125-9b2c26413d32
Varon-Mateeva, Raymonda
93a22b00-7e87-4296-b2da-82caf74bebfc
Schoenbuchner, Ines
43b65e0f-059a-41fa-a40e-bbcb968dcf63
Fiebig, Britta
86a99d73-caa3-4b21-9361-a50646910deb
Heinritz, Wolfram
4b28742f-cde3-44ae-912b-8ba89ca57fbe
Schäfer, Dieter
509ba13d-1781-4175-b359-2d79c50912a4
Gevensleben, Heidrun
665a884b-45f8-47e4-9ccd-38360cce6a06
Caux-Moncoutier, Virginie
73fa4e8f-836e-4ade-a431-aab3f22c6cb2
Fassy-Colcombet, Marion
7b832ef0-f75b-4d64-b1cd-dda5f203c05a
Cornelis, François
563da245-2cf6-4631-989a-7204180d4f4f
Mazoyer, Sylvie
6e0e32e4-7d0e-4c7c-bd80-d221d53af542
Léoné, Mélanie
b7b6f247-73ff-4ffa-8f22-aeaf49576531
Boutry-Kryza, Nadia
49b27e76-3081-4325-93ee-7302522d2a8b
Hardouin, Agnès
6d3fe06c-ec69-471c-b6ba-3cdd888a5c2a
Berthet, Pascaline
899ff4b4-4644-4735-8140-13c447e4ff27
Muller, Danièle
084442d0-4c8b-49af-a881-74d8ce18fe1b
Fricker, Jean-Pierre
61e17f08-c417-4213-b79f-2805d8c87d81
Mortemousque, Isabelle
5590c2cb-f3f8-409a-b2b3-65af46a31df4
Pujol, Pascal
c2d9280d-450d-4000-95bf-2d3d81ba0a15
Coupier, Isabelle
97ca1b6d-db10-4fd8-b8bb-e76eb6fd1c37
Lebrun, Marine
6c2b8569-4320-476a-9f17-c3ae1637872e
Kientz, Caroline
a67afe82-1f73-43d9-a3e3-c344531014d4
Longy, Michel
ee406f85-d79e-4dcf-b029-12e33b7864e2
Sevenet, Nicolas
ea9196de-8f7e-4454-ba2b-60f9bef5ac07
Stoppa-Lyonnet, Dominique
c110a3bd-17a1-4b82-9b32-75728172bfc5
Isaacs, Claudine
6e60951b-1f07-471a-8ca3-1941e83bbf83
Caldes, Trinidad
8caab9c0-bec3-44d5-8e98-c97ee3ebda7d
de la Hoya, Miguel
8e170da0-2396-4f84-ba15-14fa2ad62fb2
Heikkinen, Tuomas
0c6ae2e7-0ef1-43e0-9a7b-92d9354e6f10
Aittomäki, Kristiina
ac3ded8e-805e-4e49-9713-1e03062a2efc
Blanco, Ignacio
27cfc95d-deca-4fc4-8bfb-c162edd24e0e
Lazaro, Conxi
34576bd1-4cfb-4b16-9a51-78bdd7057bd7
Barkardottir, Rosa B.
997ac890-d2ce-4fad-b556-d7f48003ae8e
Soucy, Penny
c8606457-7865-44a4-90ce-de2b55994738
Dumont, Martine
ef010ca0-c12f-44f7-9d4f-59a78a978387
Simard, Jacques
6269fd00-31ae-40f0-b016-5f60cb9f5b96
Montagna, Marco
1e04949f-87c3-4ca4-a772-5d59a9407f07
Tognazzo, Silvia
59da386d-c349-447a-9d29-7a235f864e29
D'Andrea, Emma
93f7c816-530f-4296-89af-3164d1efe713
Fox, Stephen
e7aa2bff-d251-42cc-b6d8-965f10c8cc5f
Yan, Max
36081126-c5e6-4cc4-87ae-23a190544d1e
Rebbeck, Tim
6838eb78-7dfe-4f68-9b6a-965095bf3d49
Olopade, Olufunmilayo I.
c926d080-7dfd-49f7-ab2f-95a8e24365cc
Weitzel, Jeffrey N.
f3a4bc20-189c-4655-af63-d8b8e3ea6055
Lynch, Henry T.
4515a3de-428a-476c-ad48-621c7928e874
Ganz, Patricia A.
e7573e53-13b2-4291-80d8-a59249b827fe
Tomlinson, Gail E.
e95e0778-4a72-477d-8d44-908fb0bf9bb6
Wang, Xianshu
5c376f01-823c-4228-bd76-414a181fa3eb
Fredericksen, Zachary
77db03d0-8de3-49c7-9a20-c9d6f84027a0
Pankratz, Vernon S.
7e7d7585-2ef3-4b56-a355-3cd5eefcf0c6
Lindor, Noralane M.
95f60dee-421b-4055-a396-a3b05371762f
Szabo, Csilla
f2a1a647-1996-4f79-8c08-c2314e32eae2
Offit, Kenneth
ce1fc8a6-b5ac-434a-9d2d-4a7e1ee7ca7c
Sakr, Rita
e2243f4f-9048-4901-8f54-0640135f5d30
Gaudet, Mia
9c660071-271c-4f1b-995f-38d8ff52ce95
Bhatia, Jasmine
ce2bf805-c5be-44f8-8504-0e53ab3633cc
Kauff, Noah
e16dca27-0933-4d5f-abfc-535b3b246790
Singer, Christian F.
3ac2e574-0627-4715-ac4a-8ab7edcc3851
Tea, Muy-Kheng
c21496ab-36fe-4d20-856e-2fc2afec0669
Gschwantler-Kaulich, Daphne
08c03d3a-2158-4f5b-bee3-3c5fbd301053
Fink-Retter, Anneliese
5204f14d-94b4-4fa8-9886-3b2dbd00274a
Mai, Phuong L.
31cb800d-d6a7-4aa0-b590-4e8668ce303a
Greene, Mark H.
aefbcd26-0def-47a3-8580-0c56feb03756
Imyanitov, Evgeny
bb205f31-be6b-40d4-9d29-107594aa563f
O'Malley, Frances P.
bad04911-d30e-4820-8c22-4a97b524b135
Ozcelik, Hilmi
afe78ba7-45e4-45e9-a763-fcadbc9327fa
Glendon, Gordon
13fe2dc0-3c7a-4d5a-8c31-3848708db4ef
Toland, Amanda E.
f9fbf6de-815a-4dd6-a576-2376273be8bd
Gerdes, Anne-Marie
60e03234-c7bd-4659-a642-432c0f943474
Thomassen, Mads
c7c9230a-4f3d-42d0-89f1-b5a36d431aae
Kruse, Torben A.
b53a27bc-4eda-44dd-b479-345f5dfda90f
Jensen, Uffe
c81e860c-28fa-4424-b894-4512a4aca47e
Skytte, Anne-Bine
c5d3bada-dddb-410f-b19f-ba2d9c00f657
Caligo, Maria A.
8fd95b7b-5e69-4f7f-9513-50b3d5e86ef6
Soller, Maria
b731e46c-3010-4091-96bd-d0ea1f7839e7
Henriksson, Karin
baa79d09-f059-4f2f-aaa0-7aa49e412c07
Wachenfeldt, von Anna
2841c37b-774e-454d-8894-0fe10c9ef802
Arver, Brita
179b96e1-1740-455d-a2bc-8e4ad32fb887
Stenmark-Askmalm, Marie
90305432-3ac2-42df-a358-e097cacc85ad
Karlsson, Per
cf6072fc-3103-402a-9271-2c37bdeee52d
Ding, Yuan
5b442f28-d032-47a4-ad3e-d42bdd82ac8d
Neuhausen, Susan L.
7cb359d3-5964-460c-ad60-63b77368c042
Beattie, Mary
69f91b4b-c7ff-4968-808d-1b39d52b7550
Pharoah, Paul D.P.
75503648-dfdc-4da1-93c9-26fa44dec680
Moysich, Kirsten B.
ffae45be-b72e-41d7-996a-fb5274800133
Nathanson, Katherine L.
595fa51d-4601-446d-85ff-9151c5f9246a
Karlan, Beth Y.
0a74d552-f43d-4670-bc0c-0f860d55b15e
Gross, Jenny
f98e6417-c047-4d18-bc7f-d39d7aa3534c
John, Esther M.
52870193-e535-4d25-ab4d-11d221ea99ff
Daly, Mary B.
7d327e18-8795-40e7-af04-5dad9a3f82aa
Buys, Saundra M.
00833e1f-6211-420b-b9cb-ecb4ac8be85e
Southey, Melissa C.
56062dff-748c-47e4-99f5-044cff9da594
Hopper, John L.
bdd6f4f6-9121-4cd6-824d-b3b92bd4babf
Terry, Mary
a6f2d0b6-0bc1-4498-9fab-36dfcad95fd8
Chung, Wendy
1c9ae180-7a30-4b2f-9b57-f3d7915e0e8f
Miron, Alexander F.
c594f9b2-7a00-4567-8f4e-ceb9e55fc3aa
Goldgar, David
d4ea2c14-8cd5-49e6-b0ef-9f7c93312b5c
Chenevix-Trench, Georgia
7d222914-c6e5-47b8-9022-5874b7c82a3e
Easton, Douglas F.
2661cf5e-8fc6-4f1d-b27a-e60cac8c8819
Andrulis, Irene L.
bc0d05b1-2437-452a-b9df-0d31cfbe1435
Antoniou, Antonis C.
b5275276-df7e-42a4-9a38-6a9516924f0d
Mulligan, Anna Marie
a999fb4f-9064-4311-90fc-3e8e80a5458a
Couch, Fergus J.
778e32f1-0b19-4cf4-b38f-69dd027cad3a
Barrowdale, Daniel
507bc817-9e80-4ff2-a379-470e0d6ed2c9
Domchek, Susan M.
7d99c293-81c9-4f0e-ab2c-e2655e2b601e
Eccles, Diana
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Nevanlinna, Heli
69be7a44-2abf-4504-a47b-a50b6723701b
Ramus, Susan J.
f2a91d0b-8aab-4e57-b49f-7637767b4f57
Robson, Mark
c5e6e973-8fbe-4efd-b2b3-84c885e18b4c
Sherman, Mark
b902cc3b-75cb-42b5-a618-0390d842987c
Spurdle, Amanda B.
8158d468-cc96-4e39-9bac-fcaaa7061a72
Wappenschmidt, Barbara
b196c313-8a35-4e32-a020-10181ac41400
Lee, Andrew
a82db836-29cd-4bf5-a96a-fb6af545b310
McGuffog, Lesley
21522096-38bb-45df-aa56-caf2f27d7254
Healey, Sue
5d595192-5381-464d-85cc-71ad09a05065
Sinilnikova, Olga M.
17bb19c7-8db3-48e3-8630-0c9a78a2e1a4
Janavicius, Ramunas
314ff9ed-91c2-49cc-aa80-5ab072225a98
Hansen, Thomas vO.
61642f06-2a1e-45e3-a3ad-69309150a8d9
Nielsen, Finn C.
38defc00-22e2-4d73-9ad3-18a4115d926c
Ejlertsen, Bent
b9f56a71-7d7c-4a1d-98d2-fdd32e7a3ad7
Osorio, Ana
5d37d9d7-d889-4e14-ad7c-7b7f73f6e299
Muñoz-Repeto, Iván
465178b6-e4fb-4f8a-ba48-844c9166321d
Durán, Mercedes
5ba80f97-eeb8-452a-b589-06bfbba0088f
Godino, Javier
ace718e4-a983-49d9-ac5a-3773c1cf1979
Pertesi, Maroulio
cf1b1c3a-a9f0-49ef-9ed9-52693294aa4e
Benítez, Javier
6fa8139c-6298-4f8a-9152-de51fc294a83
Peterlongo, Paolo
af3f3db4-e3fc-45db-bbb4-91954fe857fb
Manoukian, Siranoush
87f7b60d-b65f-4655-b1d8-3b7c5dcf37d2
Peissel, Bernard
94da3e26-04ab-4665-905a-aa21969c7a94
Zaffaroni, Daniela
f88dddd8-5392-415d-bbbb-c3d8e146ecb0
Cattaneo, Elisa
1464e50c-5a43-4b8f-9ffb-272aa7aa476a
Bonanni, Bernardo
6ab53b39-2f33-42be-9c4e-eb577feb5124
Viel, Alessandra
1d927ea7-bf84-419a-aff1-6d65b67c1280
Pasini, Barbara
7731dc58-2844-4fcc-98e0-b212353037da
Papi, Laura
01bafe05-bdb9-4feb-953d-3def9b73baa8
Ottini, Laura
361443a8-6d75-4ea5-b1f8-f7a3b03f97a8
Savarese, Antonella
2777ee53-d872-4ed8-bb36-659bdb450fc8
Bernard, Loris
0a345750-134d-4b15-84a6-0c7ba05efe9b
Radice, Paolo
d5bff2d9-ed03-4a8e-a9ca-f896a1666e2c
Hamann, Ute
c47a5052-5e7b-492c-988b-38b7df2cffc6
Verheus, Martijn
1b9e09e4-c498-48b2-a746-6ab9e0649090
Meijers-Heijboer, Hanne E.J.
1662d152-1979-4cea-a8ba-49242bf0985b
Wijnen, Juul
1556ff67-a692-4d20-b2a8-d0869985558e
Gómez García, Encarna B.
bdfeeb10-870e-41e9-9141-cd36b334f92c
Nelen, Marcel R.
0ed4c29f-83a0-4c95-87e9-53184993e206
Kets, C. Marleen
062620d0-d56a-4b00-8b34-3b1e9cda85ca
Seynaeve, Caroline
1e8ad8ea-5121-4eee-88d6-45e34614f7af
Tilanus-Linthorst, Madeleine M.A.
43b9db42-f5ed-49be-bf7f-faa81240e467
van der Luijt, Rob B.
382af51c-839b-4d04-9274-34878f862fed
Os, Theo
bafeac3f-4b03-425f-a19d-9e10d7e837cf
Rookus, Matti
4a82efda-4af5-43fa-a584-91d5f8ab50d6
Frost, Debra
38874d28-24d7-47b2-b458-b121539a3ceb
Jones, J. Louise
a6a6c58f-c843-42c7-8832-7c970959610c
Evans, D. Gareth
314acefb-89fb-4eb7-a0e7-0a6949c9af6c
Lalloo, Fiona
d7ac29ee-10db-49a5-af3c-265b6d1c113d
Eeles, Ros
1101f5dc-f8ae-4102-99fb-f814695e5f9c
Izatt, Louise
5d6201a8-8a56-4923-ac9d-75dca6be0a40
Adlard, Julian
3a01574a-8ed1-4286-956c-c9e87fd89521
Davidson, Rosemarie
81692cd9-0a70-4a01-a68f-8eb623f0fbe0
Cook, Jackie
b24e3336-f47a-4590-bc3f-7e2ab7d78e0d
Donaldson, Alan
8bd5454f-be4c-4b7a-ae31-c602f391920e
Dorkins, Huw
713e497f-c4cd-4d73-a190-9d1d8bcf53b1
Gregory, Helen
d486c9b1-6c6c-4cc1-9240-9e2c7db5495e
Eason, Jacqueline
537aca11-c033-407a-920e-99b0011bea6c
Houghton, Catherine
03c28ff3-f73f-46a4-891f-b0c55ef4c1fe
Barwell, Julian
775206d7-77c1-46bb-a6ff-932204a3c2f5
Side, Lucy E.
f9e1faa2-2814-4c9e-8470-65d0f92ddcd6
McCann, Emma
e86886b8-4f81-453f-a381-41003d14d699
Murray, Alex
a720c70c-691b-4c06-843e-3c3f3c1e9963
Peock, Susan
7e420471-9ee5-4a07-9536-bfdc4c6f1297
Godwin, Andrew K.
a7e89dce-59e1-48f7-b668-42777f362435
Schmutzler, Rita K.
bf790f2e-79f3-4151-a74c-793bf14d8f6a
Rhiem, Kerstin
5fbe374e-0810-4da0-a4fa-3e311fa952d7
Engel, Christoph
e428d3b6-d668-487c-bcef-7d835e609751
Meindl, Alfons
10b41dbc-4030-4b19-976f-212367b636af
Ruehl, Ina
12a66011-501b-4ae7-b8a8-7869ed3f774d
Arnold, Norbert
2296ee7c-7ba5-48cb-8514-c0a9c4a25eb9
Niederacher, Dieter
b6a4a233-f88d-416b-a22e-9902d732d8e6
Sutter, Christian
c54383c2-0738-42cc-b0ab-c2595b4ec272
Deissler, Helmut
58cbec72-5288-4cdd-9e55-f0ca1331bb53
Gadzicki, Dorothea
b4f1469f-e0a9-4feb-b125-8f45bb99f03f
Kast, Karin
7cde00f5-f897-4c84-bb86-2ecdd6e23b6d
Preisler-Adams, Sabine
82c50384-58e6-4299-a125-9b2c26413d32
Varon-Mateeva, Raymonda
93a22b00-7e87-4296-b2da-82caf74bebfc
Schoenbuchner, Ines
43b65e0f-059a-41fa-a40e-bbcb968dcf63
Fiebig, Britta
86a99d73-caa3-4b21-9361-a50646910deb
Heinritz, Wolfram
4b28742f-cde3-44ae-912b-8ba89ca57fbe
Schäfer, Dieter
509ba13d-1781-4175-b359-2d79c50912a4
Gevensleben, Heidrun
665a884b-45f8-47e4-9ccd-38360cce6a06
Caux-Moncoutier, Virginie
73fa4e8f-836e-4ade-a431-aab3f22c6cb2
Fassy-Colcombet, Marion
7b832ef0-f75b-4d64-b1cd-dda5f203c05a
Cornelis, François
563da245-2cf6-4631-989a-7204180d4f4f
Mazoyer, Sylvie
6e0e32e4-7d0e-4c7c-bd80-d221d53af542
Léoné, Mélanie
b7b6f247-73ff-4ffa-8f22-aeaf49576531
Boutry-Kryza, Nadia
49b27e76-3081-4325-93ee-7302522d2a8b
Hardouin, Agnès
6d3fe06c-ec69-471c-b6ba-3cdd888a5c2a
Berthet, Pascaline
899ff4b4-4644-4735-8140-13c447e4ff27
Muller, Danièle
084442d0-4c8b-49af-a881-74d8ce18fe1b
Fricker, Jean-Pierre
61e17f08-c417-4213-b79f-2805d8c87d81
Mortemousque, Isabelle
5590c2cb-f3f8-409a-b2b3-65af46a31df4
Pujol, Pascal
c2d9280d-450d-4000-95bf-2d3d81ba0a15
Coupier, Isabelle
97ca1b6d-db10-4fd8-b8bb-e76eb6fd1c37
Lebrun, Marine
6c2b8569-4320-476a-9f17-c3ae1637872e
Kientz, Caroline
a67afe82-1f73-43d9-a3e3-c344531014d4
Longy, Michel
ee406f85-d79e-4dcf-b029-12e33b7864e2
Sevenet, Nicolas
ea9196de-8f7e-4454-ba2b-60f9bef5ac07
Stoppa-Lyonnet, Dominique
c110a3bd-17a1-4b82-9b32-75728172bfc5
Isaacs, Claudine
6e60951b-1f07-471a-8ca3-1941e83bbf83
Caldes, Trinidad
8caab9c0-bec3-44d5-8e98-c97ee3ebda7d
de la Hoya, Miguel
8e170da0-2396-4f84-ba15-14fa2ad62fb2
Heikkinen, Tuomas
0c6ae2e7-0ef1-43e0-9a7b-92d9354e6f10
Aittomäki, Kristiina
ac3ded8e-805e-4e49-9713-1e03062a2efc
Blanco, Ignacio
27cfc95d-deca-4fc4-8bfb-c162edd24e0e
Lazaro, Conxi
34576bd1-4cfb-4b16-9a51-78bdd7057bd7
Barkardottir, Rosa B.
997ac890-d2ce-4fad-b556-d7f48003ae8e
Soucy, Penny
c8606457-7865-44a4-90ce-de2b55994738
Dumont, Martine
ef010ca0-c12f-44f7-9d4f-59a78a978387
Simard, Jacques
6269fd00-31ae-40f0-b016-5f60cb9f5b96
Montagna, Marco
1e04949f-87c3-4ca4-a772-5d59a9407f07
Tognazzo, Silvia
59da386d-c349-447a-9d29-7a235f864e29
D'Andrea, Emma
93f7c816-530f-4296-89af-3164d1efe713
Fox, Stephen
e7aa2bff-d251-42cc-b6d8-965f10c8cc5f
Yan, Max
36081126-c5e6-4cc4-87ae-23a190544d1e
Rebbeck, Tim
6838eb78-7dfe-4f68-9b6a-965095bf3d49
Olopade, Olufunmilayo I.
c926d080-7dfd-49f7-ab2f-95a8e24365cc
Weitzel, Jeffrey N.
f3a4bc20-189c-4655-af63-d8b8e3ea6055
Lynch, Henry T.
4515a3de-428a-476c-ad48-621c7928e874
Ganz, Patricia A.
e7573e53-13b2-4291-80d8-a59249b827fe
Tomlinson, Gail E.
e95e0778-4a72-477d-8d44-908fb0bf9bb6
Wang, Xianshu
5c376f01-823c-4228-bd76-414a181fa3eb
Fredericksen, Zachary
77db03d0-8de3-49c7-9a20-c9d6f84027a0
Pankratz, Vernon S.
7e7d7585-2ef3-4b56-a355-3cd5eefcf0c6
Lindor, Noralane M.
95f60dee-421b-4055-a396-a3b05371762f
Szabo, Csilla
f2a1a647-1996-4f79-8c08-c2314e32eae2
Offit, Kenneth
ce1fc8a6-b5ac-434a-9d2d-4a7e1ee7ca7c
Sakr, Rita
e2243f4f-9048-4901-8f54-0640135f5d30
Gaudet, Mia
9c660071-271c-4f1b-995f-38d8ff52ce95
Bhatia, Jasmine
ce2bf805-c5be-44f8-8504-0e53ab3633cc
Kauff, Noah
e16dca27-0933-4d5f-abfc-535b3b246790
Singer, Christian F.
3ac2e574-0627-4715-ac4a-8ab7edcc3851
Tea, Muy-Kheng
c21496ab-36fe-4d20-856e-2fc2afec0669
Gschwantler-Kaulich, Daphne
08c03d3a-2158-4f5b-bee3-3c5fbd301053
Fink-Retter, Anneliese
5204f14d-94b4-4fa8-9886-3b2dbd00274a
Mai, Phuong L.
31cb800d-d6a7-4aa0-b590-4e8668ce303a
Greene, Mark H.
aefbcd26-0def-47a3-8580-0c56feb03756
Imyanitov, Evgeny
bb205f31-be6b-40d4-9d29-107594aa563f
O'Malley, Frances P.
bad04911-d30e-4820-8c22-4a97b524b135
Ozcelik, Hilmi
afe78ba7-45e4-45e9-a763-fcadbc9327fa
Glendon, Gordon
13fe2dc0-3c7a-4d5a-8c31-3848708db4ef
Toland, Amanda E.
f9fbf6de-815a-4dd6-a576-2376273be8bd
Gerdes, Anne-Marie
60e03234-c7bd-4659-a642-432c0f943474
Thomassen, Mads
c7c9230a-4f3d-42d0-89f1-b5a36d431aae
Kruse, Torben A.
b53a27bc-4eda-44dd-b479-345f5dfda90f
Jensen, Uffe
c81e860c-28fa-4424-b894-4512a4aca47e
Skytte, Anne-Bine
c5d3bada-dddb-410f-b19f-ba2d9c00f657
Caligo, Maria A.
8fd95b7b-5e69-4f7f-9513-50b3d5e86ef6
Soller, Maria
b731e46c-3010-4091-96bd-d0ea1f7839e7
Henriksson, Karin
baa79d09-f059-4f2f-aaa0-7aa49e412c07
Wachenfeldt, von Anna
2841c37b-774e-454d-8894-0fe10c9ef802
Arver, Brita
179b96e1-1740-455d-a2bc-8e4ad32fb887
Stenmark-Askmalm, Marie
90305432-3ac2-42df-a358-e097cacc85ad
Karlsson, Per
cf6072fc-3103-402a-9271-2c37bdeee52d
Ding, Yuan
5b442f28-d032-47a4-ad3e-d42bdd82ac8d
Neuhausen, Susan L.
7cb359d3-5964-460c-ad60-63b77368c042
Beattie, Mary
69f91b4b-c7ff-4968-808d-1b39d52b7550
Pharoah, Paul D.P.
75503648-dfdc-4da1-93c9-26fa44dec680
Moysich, Kirsten B.
ffae45be-b72e-41d7-996a-fb5274800133
Nathanson, Katherine L.
595fa51d-4601-446d-85ff-9151c5f9246a
Karlan, Beth Y.
0a74d552-f43d-4670-bc0c-0f860d55b15e
Gross, Jenny
f98e6417-c047-4d18-bc7f-d39d7aa3534c
John, Esther M.
52870193-e535-4d25-ab4d-11d221ea99ff
Daly, Mary B.
7d327e18-8795-40e7-af04-5dad9a3f82aa
Buys, Saundra M.
00833e1f-6211-420b-b9cb-ecb4ac8be85e
Southey, Melissa C.
56062dff-748c-47e4-99f5-044cff9da594
Hopper, John L.
bdd6f4f6-9121-4cd6-824d-b3b92bd4babf
Terry, Mary
a6f2d0b6-0bc1-4498-9fab-36dfcad95fd8
Chung, Wendy
1c9ae180-7a30-4b2f-9b57-f3d7915e0e8f
Miron, Alexander F.
c594f9b2-7a00-4567-8f4e-ceb9e55fc3aa
Goldgar, David
d4ea2c14-8cd5-49e6-b0ef-9f7c93312b5c
Chenevix-Trench, Georgia
7d222914-c6e5-47b8-9022-5874b7c82a3e
Easton, Douglas F.
2661cf5e-8fc6-4f1d-b27a-e60cac8c8819
Andrulis, Irene L.
bc0d05b1-2437-452a-b9df-0d31cfbe1435
Antoniou, Antonis C.
b5275276-df7e-42a4-9a38-6a9516924f0d

Mulligan, Anna Marie, Couch, Fergus J., Barrowdale, Daniel, Domchek, Susan M., Eccles, Diana, Nevanlinna, Heli, Ramus, Susan J., Robson, Mark, Sherman, Mark, Spurdle, Amanda B., Wappenschmidt, Barbara, Lee, Andrew, McGuffog, Lesley, Healey, Sue, Sinilnikova, Olga M., Janavicius, Ramunas, Hansen, Thomas vO., Nielsen, Finn C., Ejlertsen, Bent, Osorio, Ana, Muñoz-Repeto, Iván, Durán, Mercedes, Godino, Javier, Pertesi, Maroulio, Benítez, Javier, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Cattaneo, Elisa, Bonanni, Bernardo, Viel, Alessandra, Pasini, Barbara, Papi, Laura, Ottini, Laura, Savarese, Antonella, Bernard, Loris, Radice, Paolo, Hamann, Ute, Verheus, Martijn, Meijers-Heijboer, Hanne E.J., Wijnen, Juul, Gómez García, Encarna B., Nelen, Marcel R., Kets, C. Marleen, Seynaeve, Caroline, Tilanus-Linthorst, Madeleine M.A., van der Luijt, Rob B., Os, Theo, Rookus, Matti, Frost, Debra, Jones, J. Louise, Evans, D. Gareth, Lalloo, Fiona, Eeles, Ros, Izatt, Louise, Adlard, Julian, Davidson, Rosemarie, Cook, Jackie, Donaldson, Alan, Dorkins, Huw, Gregory, Helen, Eason, Jacqueline, Houghton, Catherine, Barwell, Julian, Side, Lucy E., McCann, Emma, Murray, Alex, Peock, Susan, Godwin, Andrew K., Schmutzler, Rita K., Rhiem, Kerstin, Engel, Christoph, Meindl, Alfons, Ruehl, Ina, Arnold, Norbert, Niederacher, Dieter, Sutter, Christian, Deissler, Helmut, Gadzicki, Dorothea, Kast, Karin, Preisler-Adams, Sabine, Varon-Mateeva, Raymonda, Schoenbuchner, Ines, Fiebig, Britta, Heinritz, Wolfram, Schäfer, Dieter, Gevensleben, Heidrun, Caux-Moncoutier, Virginie, Fassy-Colcombet, Marion, Cornelis, François, Mazoyer, Sylvie, Léoné, Mélanie, Boutry-Kryza, Nadia, Hardouin, Agnès, Berthet, Pascaline, Muller, Danièle, Fricker, Jean-Pierre, Mortemousque, Isabelle, Pujol, Pascal, Coupier, Isabelle, Lebrun, Marine, Kientz, Caroline, Longy, Michel, Sevenet, Nicolas, Stoppa-Lyonnet, Dominique, Isaacs, Claudine, Caldes, Trinidad, de la Hoya, Miguel, Heikkinen, Tuomas, Aittomäki, Kristiina, Blanco, Ignacio, Lazaro, Conxi, Barkardottir, Rosa B., Soucy, Penny, Dumont, Martine, Simard, Jacques, Montagna, Marco, Tognazzo, Silvia, D'Andrea, Emma, Fox, Stephen, Yan, Max, Rebbeck, Tim, Olopade, Olufunmilayo I., Weitzel, Jeffrey N., Lynch, Henry T., Ganz, Patricia A., Tomlinson, Gail E., Wang, Xianshu, Fredericksen, Zachary, Pankratz, Vernon S., Lindor, Noralane M., Szabo, Csilla, Offit, Kenneth, Sakr, Rita, Gaudet, Mia, Bhatia, Jasmine, Kauff, Noah, Singer, Christian F., Tea, Muy-Kheng, Gschwantler-Kaulich, Daphne, Fink-Retter, Anneliese, Mai, Phuong L., Greene, Mark H., Imyanitov, Evgeny, O'Malley, Frances P., Ozcelik, Hilmi, Glendon, Gordon, Toland, Amanda E., Gerdes, Anne-Marie, Thomassen, Mads, Kruse, Torben A., Jensen, Uffe, Skytte, Anne-Bine, Caligo, Maria A., Soller, Maria, Henriksson, Karin, Wachenfeldt, von Anna, Arver, Brita, Stenmark-Askmalm, Marie, Karlsson, Per, Ding, Yuan, Neuhausen, Susan L., Beattie, Mary, Pharoah, Paul D.P., Moysich, Kirsten B., Nathanson, Katherine L., Karlan, Beth Y., Gross, Jenny, John, Esther M., Daly, Mary B., Buys, Saundra M., Southey, Melissa C., Hopper, John L., Terry, Mary, Chung, Wendy, Miron, Alexander F., Goldgar, David, Chenevix-Trench, Georgia, Easton, Douglas F., Andrulis, Irene L. and Antoniou, Antonis C. (2011) Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Research, 13 (6), R110. (doi:10.1186/bcr3052). (PMID:22053997)

Record type: Article

Abstract

INTRODUCTION: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour.

METHODS: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumour, to assess the associations of 12 loci with breast cancer tumour characteristics. Associations were evaluated using a retrospective cohort approach.

RESULTS: The results suggested stronger associations with ER-positive breast cancer than ER-negative for 11 loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, single nucleotide polymorphism (SNP) rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele hazard ratio (HR) for ER-positive = 1.35, 95% CI: 1.17 to 1.56 vs HR = 0.91, 95% CI: 0.85 to 0.98 for ER-negative, P-heterogeneity = 6.5 × 10-6). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and 1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status.

CONCLUSIONS: The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers.

This record has no associated files available for download.

More information

Published date: 2 November 2011
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 352580
URI: http://eprints.soton.ac.uk/id/eprint/352580
PURE UUID: a0c95517-0926-4a68-89cb-ccb2d1790fa7
ORCID for Diana Eccles: ORCID iD orcid.org/0000-0002-9935-3169

Catalogue record

Date deposited: 16 May 2013 13:05
Last modified: 15 Mar 2024 02:40

Export record

Altmetrics

Contributors

Author: Anna Marie Mulligan
Author: Fergus J. Couch
Author: Daniel Barrowdale
Author: Susan M. Domchek
Author: Diana Eccles ORCID iD
Author: Heli Nevanlinna
Author: Susan J. Ramus
Author: Mark Robson
Author: Mark Sherman
Author: Amanda B. Spurdle
Author: Barbara Wappenschmidt
Author: Andrew Lee
Author: Lesley McGuffog
Author: Sue Healey
Author: Olga M. Sinilnikova
Author: Ramunas Janavicius
Author: Thomas vO. Hansen
Author: Finn C. Nielsen
Author: Bent Ejlertsen
Author: Ana Osorio
Author: Iván Muñoz-Repeto
Author: Mercedes Durán
Author: Javier Godino
Author: Maroulio Pertesi
Author: Javier Benítez
Author: Paolo Peterlongo
Author: Siranoush Manoukian
Author: Bernard Peissel
Author: Daniela Zaffaroni
Author: Elisa Cattaneo
Author: Bernardo Bonanni
Author: Alessandra Viel
Author: Barbara Pasini
Author: Laura Papi
Author: Laura Ottini
Author: Antonella Savarese
Author: Loris Bernard
Author: Paolo Radice
Author: Ute Hamann
Author: Martijn Verheus
Author: Hanne E.J. Meijers-Heijboer
Author: Juul Wijnen
Author: Encarna B. Gómez García
Author: Marcel R. Nelen
Author: C. Marleen Kets
Author: Caroline Seynaeve
Author: Madeleine M.A. Tilanus-Linthorst
Author: Rob B. van der Luijt
Author: Theo Os
Author: Matti Rookus
Author: Debra Frost
Author: J. Louise Jones
Author: D. Gareth Evans
Author: Fiona Lalloo
Author: Ros Eeles
Author: Louise Izatt
Author: Julian Adlard
Author: Rosemarie Davidson
Author: Jackie Cook
Author: Alan Donaldson
Author: Huw Dorkins
Author: Helen Gregory
Author: Jacqueline Eason
Author: Catherine Houghton
Author: Julian Barwell
Author: Lucy E. Side
Author: Emma McCann
Author: Alex Murray
Author: Susan Peock
Author: Andrew K. Godwin
Author: Rita K. Schmutzler
Author: Kerstin Rhiem
Author: Christoph Engel
Author: Alfons Meindl
Author: Ina Ruehl
Author: Norbert Arnold
Author: Dieter Niederacher
Author: Christian Sutter
Author: Helmut Deissler
Author: Dorothea Gadzicki
Author: Karin Kast
Author: Sabine Preisler-Adams
Author: Raymonda Varon-Mateeva
Author: Ines Schoenbuchner
Author: Britta Fiebig
Author: Wolfram Heinritz
Author: Dieter Schäfer
Author: Heidrun Gevensleben
Author: Virginie Caux-Moncoutier
Author: Marion Fassy-Colcombet
Author: François Cornelis
Author: Sylvie Mazoyer
Author: Mélanie Léoné
Author: Nadia Boutry-Kryza
Author: Agnès Hardouin
Author: Pascaline Berthet
Author: Danièle Muller
Author: Jean-Pierre Fricker
Author: Isabelle Mortemousque
Author: Pascal Pujol
Author: Isabelle Coupier
Author: Marine Lebrun
Author: Caroline Kientz
Author: Michel Longy
Author: Nicolas Sevenet
Author: Dominique Stoppa-Lyonnet
Author: Claudine Isaacs
Author: Trinidad Caldes
Author: Miguel de la Hoya
Author: Tuomas Heikkinen
Author: Kristiina Aittomäki
Author: Ignacio Blanco
Author: Conxi Lazaro
Author: Rosa B. Barkardottir
Author: Penny Soucy
Author: Martine Dumont
Author: Jacques Simard
Author: Marco Montagna
Author: Silvia Tognazzo
Author: Emma D'Andrea
Author: Stephen Fox
Author: Max Yan
Author: Tim Rebbeck
Author: Olufunmilayo I. Olopade
Author: Jeffrey N. Weitzel
Author: Henry T. Lynch
Author: Patricia A. Ganz
Author: Gail E. Tomlinson
Author: Xianshu Wang
Author: Zachary Fredericksen
Author: Vernon S. Pankratz
Author: Noralane M. Lindor
Author: Csilla Szabo
Author: Kenneth Offit
Author: Rita Sakr
Author: Mia Gaudet
Author: Jasmine Bhatia
Author: Noah Kauff
Author: Christian F. Singer
Author: Muy-Kheng Tea
Author: Daphne Gschwantler-Kaulich
Author: Anneliese Fink-Retter
Author: Phuong L. Mai
Author: Mark H. Greene
Author: Evgeny Imyanitov
Author: Frances P. O'Malley
Author: Hilmi Ozcelik
Author: Gordon Glendon
Author: Amanda E. Toland
Author: Anne-Marie Gerdes
Author: Mads Thomassen
Author: Torben A. Kruse
Author: Uffe Jensen
Author: Anne-Bine Skytte
Author: Maria A. Caligo
Author: Maria Soller
Author: Karin Henriksson
Author: von Anna Wachenfeldt
Author: Brita Arver
Author: Marie Stenmark-Askmalm
Author: Per Karlsson
Author: Yuan Ding
Author: Susan L. Neuhausen
Author: Mary Beattie
Author: Paul D.P. Pharoah
Author: Kirsten B. Moysich
Author: Katherine L. Nathanson
Author: Beth Y. Karlan
Author: Jenny Gross
Author: Esther M. John
Author: Mary B. Daly
Author: Saundra M. Buys
Author: Melissa C. Southey
Author: John L. Hopper
Author: Mary Terry
Author: Wendy Chung
Author: Alexander F. Miron
Author: David Goldgar
Author: Georgia Chenevix-Trench
Author: Douglas F. Easton
Author: Irene L. Andrulis
Author: Antonis C. Antoniou

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×