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Hollow porous particles in metered dose inhalers

Hollow porous particles in metered dose inhalers
Hollow porous particles in metered dose inhalers
PURPOSE: To assess the physical stability and aerosol characteristics of suspensions of hollow porous microspheres (PulmoSpheres) in HFA-134a.

METHODS: Cromolyn sodium, albuterol sulfate, and formoterol fumarate microspheres were prepared by a spray-drying method. Particle size and morphology were determined via electron microscopy. Particle aggregation and suspension creaming times were assessed visually, and aerosol performance was determined via Andersen cascade impaction and dose uniformity studies.

RESULTS: The hollow porous particle morphology allows the propellant to permeate freely within the particles creating a novel form of suspension termed a homodispersion, wherein the dispersed and continuous phases are identical, separated by an insoluble interfacial layer of drug and excipient. Homodispersion formation improves suspension stability by minimizing the difference in density between the particles and the medium, and by reducing attractive forces between particles. The improved physical stability leads to excellent dose uniformity. Excellent aerosolization efficiencies are also observed with PulmoSpheres formulations, with fine particle fractions of about 70%.

CONCLUSIONS: The formation of hollow porous particles provides a new formulation technology for stabilizing suspensions of drugs in hydrofluoroalkane propellants with improved physical stability, content uniformity, and aerosolization efficiency.
asthma, pulmonary drug delivery, metered dose inhaler, particle engineering, spray-drying, suspensions, HFA-134a
0724-8741
168-174
Dellamary, Luis A.
8296316a-234b-4f38-8625-b3ab002ac170
Tarara, Thomas E.
af4bf041-4184-4cf9-be66-dd5fc51857b3
Smith, Dan J.
f60667ea-c2a2-4638-8101-c78a45d5bfc7
Woelk, Christopher H.
4d3af0fd-658f-4626-b3b5-49a6192bcf7d
Adractas, Anastasios
1acd2906-797c-43de-bbe8-b915c696df6f
Costello, Michael L.
90e82dad-10d8-4383-a2c0-01723596a030
Gill, Howard
43639350-1b9d-4624-a3c7-c967666a07c0
Weers, Jeffry G.
2dde8e48-3969-444f-b4ed-cc4f4cf40088
Dellamary, Luis A.
8296316a-234b-4f38-8625-b3ab002ac170
Tarara, Thomas E.
af4bf041-4184-4cf9-be66-dd5fc51857b3
Smith, Dan J.
f60667ea-c2a2-4638-8101-c78a45d5bfc7
Woelk, Christopher H.
4d3af0fd-658f-4626-b3b5-49a6192bcf7d
Adractas, Anastasios
1acd2906-797c-43de-bbe8-b915c696df6f
Costello, Michael L.
90e82dad-10d8-4383-a2c0-01723596a030
Gill, Howard
43639350-1b9d-4624-a3c7-c967666a07c0
Weers, Jeffry G.
2dde8e48-3969-444f-b4ed-cc4f4cf40088

Dellamary, Luis A., Tarara, Thomas E., Smith, Dan J., Woelk, Christopher H., Adractas, Anastasios, Costello, Michael L., Gill, Howard and Weers, Jeffry G. (2000) Hollow porous particles in metered dose inhalers. Pharmaceutical Research, 17 (2), 168-174. (PMID:10751031)

Record type: Article

Abstract

PURPOSE: To assess the physical stability and aerosol characteristics of suspensions of hollow porous microspheres (PulmoSpheres) in HFA-134a.

METHODS: Cromolyn sodium, albuterol sulfate, and formoterol fumarate microspheres were prepared by a spray-drying method. Particle size and morphology were determined via electron microscopy. Particle aggregation and suspension creaming times were assessed visually, and aerosol performance was determined via Andersen cascade impaction and dose uniformity studies.

RESULTS: The hollow porous particle morphology allows the propellant to permeate freely within the particles creating a novel form of suspension termed a homodispersion, wherein the dispersed and continuous phases are identical, separated by an insoluble interfacial layer of drug and excipient. Homodispersion formation improves suspension stability by minimizing the difference in density between the particles and the medium, and by reducing attractive forces between particles. The improved physical stability leads to excellent dose uniformity. Excellent aerosolization efficiencies are also observed with PulmoSpheres formulations, with fine particle fractions of about 70%.

CONCLUSIONS: The formation of hollow porous particles provides a new formulation technology for stabilizing suspensions of drugs in hydrofluoroalkane propellants with improved physical stability, content uniformity, and aerosolization efficiency.

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More information

Published date: February 2000
Keywords: asthma, pulmonary drug delivery, metered dose inhaler, particle engineering, spray-drying, suspensions, HFA-134a
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 352585
URI: https://eprints.soton.ac.uk/id/eprint/352585
ISSN: 0724-8741
PURE UUID: 9cce1fd9-a357-445f-868a-bedb60c8953a

Catalogue record

Date deposited: 21 May 2013 09:14
Last modified: 16 Jul 2019 21:33

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Contributors

Author: Luis A. Dellamary
Author: Thomas E. Tarara
Author: Dan J. Smith
Author: Anastasios Adractas
Author: Michael L. Costello
Author: Howard Gill
Author: Jeffry G. Weers

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