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Sequence-specific synthesis of macromolecules using DNA-templated chemistry

Sequence-specific synthesis of macromolecules using DNA-templated chemistry
Sequence-specific synthesis of macromolecules using DNA-templated chemistry
Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control
1359-7345
5614-5616
Milnes, Phillip J.
fcb9cc31-266f-477a-ab39-a32793470c0a
McKee, Mireya L.
189d4b60-90b1-4e2f-b95e-2c534bc89087
Bath, Jonathan
fc276b69-5e06-43e9-a3d5-d7324bc23267
Song, Lijiang
f5229e9b-af29-4237-a5e7-110e571f21d4
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
Turberfield, Andrew J.
e12469b0-4ae6-44a5-9099-e9273ab803d4
O'Reilly, Rachel K.
086bc91e-2303-4543-b79c-ae16ada0b101
Milnes, Phillip J.
fcb9cc31-266f-477a-ab39-a32793470c0a
McKee, Mireya L.
189d4b60-90b1-4e2f-b95e-2c534bc89087
Bath, Jonathan
fc276b69-5e06-43e9-a3d5-d7324bc23267
Song, Lijiang
f5229e9b-af29-4237-a5e7-110e571f21d4
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
Turberfield, Andrew J.
e12469b0-4ae6-44a5-9099-e9273ab803d4
O'Reilly, Rachel K.
086bc91e-2303-4543-b79c-ae16ada0b101

Milnes, Phillip J., McKee, Mireya L., Bath, Jonathan, Song, Lijiang, Stulz, Eugen, Turberfield, Andrew J. and O'Reilly, Rachel K. (2012) Sequence-specific synthesis of macromolecules using DNA-templated chemistry. Chemical Communications, 48 (45), 5614-5616. (doi:10.1039/c2cc31975f).

Record type: Article

Abstract

Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control

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Published date: 17 April 2012
Organisations: Chemistry

Identifiers

Local EPrints ID: 352608
URI: http://eprints.soton.ac.uk/id/eprint/352608
ISSN: 1359-7345
PURE UUID: c19421e4-688e-4dcd-8693-189171aef275
ORCID for Eugen Stulz: ORCID iD orcid.org/0000-0002-5302-2276

Catalogue record

Date deposited: 16 May 2013 07:43
Last modified: 12 Nov 2019 01:46

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Contributors

Author: Phillip J. Milnes
Author: Mireya L. McKee
Author: Jonathan Bath
Author: Lijiang Song
Author: Eugen Stulz ORCID iD
Author: Andrew J. Turberfield
Author: Rachel K. O'Reilly

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