Epitope mapping with solid-phase peptides: identification of type-, subspecies-, species- and genus-reactive antibody binding domains on the major outer membrane protein of Chlamydia trachomatis
Epitope mapping with solid-phase peptides: identification of type-, subspecies-, species- and genus-reactive antibody binding domains on the major outer membrane protein of Chlamydia trachomatis
The major outer membrane protein (MOMP) of Chlamydia trachomatis carries serovar-, subspecies-, species- and genus immunodomains, antibodies to which may be protective. We have compared the inferred amino acid sequences for MOMP from different serovars of C. trachomatis and from Chlamydia psittaci to identify the likely locations of these sero-taxonomic epitopes. Overlapping peptides corresponding to each of these regions were synthesized on a solid phase and probed with monoclonal antibodies (MAbs) of appropriate specificities. We describe the primary structures of the binding sites of MAb to each of these four epitopes on C. trachomatis serovar L1 MOMP.
673-679
Conlan, J.W.
80eceadc-14b1-481d-9812-14e7562d332f
Clarke, I.N.
ff6c9324-3547-4039-bb2c-10c0b3327a8b
Ward, M.E.
a199bc96-75b6-415c-bffe-e68e8a00b468
September 1988
Conlan, J.W.
80eceadc-14b1-481d-9812-14e7562d332f
Clarke, I.N.
ff6c9324-3547-4039-bb2c-10c0b3327a8b
Ward, M.E.
a199bc96-75b6-415c-bffe-e68e8a00b468
Conlan, J.W., Clarke, I.N. and Ward, M.E.
(1988)
Epitope mapping with solid-phase peptides: identification of type-, subspecies-, species- and genus-reactive antibody binding domains on the major outer membrane protein of Chlamydia trachomatis.
Molecular Microbiology, 2 (5), .
(PMID:2460719)
Abstract
The major outer membrane protein (MOMP) of Chlamydia trachomatis carries serovar-, subspecies-, species- and genus immunodomains, antibodies to which may be protective. We have compared the inferred amino acid sequences for MOMP from different serovars of C. trachomatis and from Chlamydia psittaci to identify the likely locations of these sero-taxonomic epitopes. Overlapping peptides corresponding to each of these regions were synthesized on a solid phase and probed with monoclonal antibodies (MAbs) of appropriate specificities. We describe the primary structures of the binding sites of MAb to each of these four epitopes on C. trachomatis serovar L1 MOMP.
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Published date: September 1988
Organisations:
Faculty of Medicine
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Local EPrints ID: 352624
URI: http://eprints.soton.ac.uk/id/eprint/352624
ISSN: 0950-382X
PURE UUID: 16401531-0509-444a-af85-f32b62f27352
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Date deposited: 03 Jun 2013 15:18
Last modified: 11 Dec 2021 02:35
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Author:
J.W. Conlan
Author:
M.E. Ward
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