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Human enteric caliciviruses have a unique genome structure and are distinct from the Norwalk-like viruses

Human enteric caliciviruses have a unique genome structure and are distinct from the Norwalk-like viruses
Human enteric caliciviruses have a unique genome structure and are distinct from the Norwalk-like viruses
Classic human enteric caliciviruses (HuCVs) have a distinctive morphology and are primarily associated with pediatric acute gastroenteritis. Although morphologically distinct from the small round structured viruses (SRSVs), the classic HuCVs are thought to be closely related and were anticipated to have a similar genome organisation. We report the first genome sequence and molecular characterisation of a classic human enteric calicivirus associated with a case of acute vomiting and diarrhoea in an infant. The RNA genome (7266 nt) is smaller than the genome of SRSVs from the two genetic groups and has a unique arrangement of open reading frames. Further analysis of the 3' terminal 3 kb from a second unrelated isolate confirmed this genomic organisation. Analysis of capsid and RNA polymerase sequences together with the unique genomic organisation of classic HuCV suggest these viruses are more closely related to the animal caliciviruses than the enteric SRSV group of viruses.
0304-8608
1345-1356
Liu, B.L.
1e6ef423-fbfb-4c45-aee6-29b667878629
Clarke, I.N.
ff6c9324-3547-4039-bb2c-10c0b3327a8b
Caul, E.O.
3ab60e6e-ca41-4196-a205-4c0075fd3767
Lambden, P.R.
e99ecc21-50d7-4a43-9e79-efba46592c77
Liu, B.L.
1e6ef423-fbfb-4c45-aee6-29b667878629
Clarke, I.N.
ff6c9324-3547-4039-bb2c-10c0b3327a8b
Caul, E.O.
3ab60e6e-ca41-4196-a205-4c0075fd3767
Lambden, P.R.
e99ecc21-50d7-4a43-9e79-efba46592c77

Liu, B.L., Clarke, I.N., Caul, E.O. and Lambden, P.R. (1995) Human enteric caliciviruses have a unique genome structure and are distinct from the Norwalk-like viruses. Archives of Virology, 140 (8), 1345-1356. (doi:10.1007/BF01322662). (PMID:7661689)

Record type: Article

Abstract

Classic human enteric caliciviruses (HuCVs) have a distinctive morphology and are primarily associated with pediatric acute gastroenteritis. Although morphologically distinct from the small round structured viruses (SRSVs), the classic HuCVs are thought to be closely related and were anticipated to have a similar genome organisation. We report the first genome sequence and molecular characterisation of a classic human enteric calicivirus associated with a case of acute vomiting and diarrhoea in an infant. The RNA genome (7266 nt) is smaller than the genome of SRSVs from the two genetic groups and has a unique arrangement of open reading frames. Further analysis of the 3' terminal 3 kb from a second unrelated isolate confirmed this genomic organisation. Analysis of capsid and RNA polymerase sequences together with the unique genomic organisation of classic HuCV suggest these viruses are more closely related to the animal caliciviruses than the enteric SRSV group of viruses.

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Published date: 1 August 1995
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 352658
URI: https://eprints.soton.ac.uk/id/eprint/352658
ISSN: 0304-8608
PURE UUID: 5bac16fe-4584-4b49-98da-a87dc4e4cf79
ORCID for I.N. Clarke: ORCID iD orcid.org/0000-0002-4938-1620

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Date deposited: 05 Jun 2013 12:42
Last modified: 06 Jun 2018 13:19

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Contributors

Author: B.L. Liu
Author: I.N. Clarke ORCID iD
Author: E.O. Caul
Author: P.R. Lambden

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