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The CD45 locus in cattle: allelic polymorphism and evidence for exceptional positive natural selection

The CD45 locus in cattle: allelic polymorphism and evidence for exceptional positive natural selection
The CD45 locus in cattle: allelic polymorphism and evidence for exceptional positive natural selection
Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with European B. taurus, and a third ascribed to an indigenous African sub-species of cattle. Due to their extended coevolution, indigenous African herbivores are generally tolerant to endemic African pathogens. We are interested in identifying alleles derived from the indigenous African cattle that may be associated with tolerance to African pathogens. An analysis of the locus which encodes the abundant plasma membrane-associated tyrosine phosphatase, CD45, identified three highly divergent allelic families in Kenya Boran cattle. Analysis of allelic distribution in a diverse range of cattle populations suggests a European B. taurus, an Asian B. indicus, and an African origin. This demonstrates not only significant allelic polymorphism at the CD45 locus in cattle but also convincing autosomal evidence for a distinct African sub-species of cattle. Furthermore, maximum-likelihood analysis of selection pressures revealed that the CD45 locus is subject to exceptionally strong natural selection which we suggest may be pathogen driven.
cattle, CD45RO, polymorphism, natural selection
276-283
Ballingall, Keith T.
7fc52eb5-c74a-460f-bac3-6d1289ba342f
Waibochi, Lillian
d53b2b9d-e329-47c7-ba76-fc98a72d2507
Holmes, Edward C.
0dab0ee7-07f4-429c-a809-e181fde89b0f
Woelk, Christipher H.
4d3af0fd-658f-4626-b3b5-49a6192bcf7d
MacHugh, Niall D.
42c2a0cb-8798-4cda-82f3-28b67665333d
Lutje, Vittoria
bf446cae-0a94-4464-a417-47e036e157dc
McKeever, Declan J.
ba63e011-fe72-484d-b259-569fcf148fa4
Ballingall, Keith T.
7fc52eb5-c74a-460f-bac3-6d1289ba342f
Waibochi, Lillian
d53b2b9d-e329-47c7-ba76-fc98a72d2507
Holmes, Edward C.
0dab0ee7-07f4-429c-a809-e181fde89b0f
Woelk, Christipher H.
4d3af0fd-658f-4626-b3b5-49a6192bcf7d
MacHugh, Niall D.
42c2a0cb-8798-4cda-82f3-28b67665333d
Lutje, Vittoria
bf446cae-0a94-4464-a417-47e036e157dc
McKeever, Declan J.
ba63e011-fe72-484d-b259-569fcf148fa4

Ballingall, Keith T., Waibochi, Lillian, Holmes, Edward C., Woelk, Christipher H., MacHugh, Niall D., Lutje, Vittoria and McKeever, Declan J. (2001) The CD45 locus in cattle: allelic polymorphism and evidence for exceptional positive natural selection. Immunogenetics, 52 (3-4), 276-283. (doi:10.1007/S002510000276). (PMID:11220630)

Record type: Article

Abstract

Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with European B. taurus, and a third ascribed to an indigenous African sub-species of cattle. Due to their extended coevolution, indigenous African herbivores are generally tolerant to endemic African pathogens. We are interested in identifying alleles derived from the indigenous African cattle that may be associated with tolerance to African pathogens. An analysis of the locus which encodes the abundant plasma membrane-associated tyrosine phosphatase, CD45, identified three highly divergent allelic families in Kenya Boran cattle. Analysis of allelic distribution in a diverse range of cattle populations suggests a European B. taurus, an Asian B. indicus, and an African origin. This demonstrates not only significant allelic polymorphism at the CD45 locus in cattle but also convincing autosomal evidence for a distinct African sub-species of cattle. Furthermore, maximum-likelihood analysis of selection pressures revealed that the CD45 locus is subject to exceptionally strong natural selection which we suggest may be pathogen driven.

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More information

Published date: January 2001
Keywords: cattle, CD45RO, polymorphism, natural selection
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 352721
URI: https://eprints.soton.ac.uk/id/eprint/352721
PURE UUID: a73feec3-1684-4c9d-a740-7aec504b2f9c

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Date deposited: 06 Jun 2013 09:19
Last modified: 16 Jul 2019 21:33

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Contributors

Author: Keith T. Ballingall
Author: Lillian Waibochi
Author: Edward C. Holmes
Author: Niall D. MacHugh
Author: Vittoria Lutje
Author: Declan J. McKeever

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