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Evidence for the non-quasispecies evolution of RNA viruses

Evidence for the non-quasispecies evolution of RNA viruses
Evidence for the non-quasispecies evolution of RNA viruses
The quasispecies model of RNA virus evolution differs from those formulated in conventional population genetics in that neutral mutations do not lead to genetic drift of the population, and natural selection acts on the mutant distribution as a whole rather than on individual variants. By computer simulation, we show that this model could be inappropriate for many RNA viruses because the neutral sequence space may be too large to allow the formation of a quasispecies distribution. This view is supported by our analysis of gene sequences from vesicular stomatitis virus, which is considered a prototype RNA virus quasispecies. Our results are relevant to the evolution of RNA systems in general.
987-994
Jenkins, Gareth M.
54ee2d8f-e7a9-4140-8bfd-c9d574789016
Worobey, Michael
ae778990-083c-42a1-a6d7-d6f3602c5294
Woelk, C.H.
4d3af0fd-658f-4626-b3b5-49a6192bcf7d
Holmes, Edward C.
0dab0ee7-07f4-429c-a809-e181fde89b0f
Jenkins, Gareth M.
54ee2d8f-e7a9-4140-8bfd-c9d574789016
Worobey, Michael
ae778990-083c-42a1-a6d7-d6f3602c5294
Woelk, C.H.
4d3af0fd-658f-4626-b3b5-49a6192bcf7d
Holmes, Edward C.
0dab0ee7-07f4-429c-a809-e181fde89b0f

Jenkins, Gareth M., Worobey, Michael, Woelk, C.H. and Holmes, Edward C. (2001) Evidence for the non-quasispecies evolution of RNA viruses. Molecular Biology and Evolution, 18 (6), 987-994. (PMID:11371587)

Record type: Article

Abstract

The quasispecies model of RNA virus evolution differs from those formulated in conventional population genetics in that neutral mutations do not lead to genetic drift of the population, and natural selection acts on the mutant distribution as a whole rather than on individual variants. By computer simulation, we show that this model could be inappropriate for many RNA viruses because the neutral sequence space may be too large to allow the formation of a quasispecies distribution. This view is supported by our analysis of gene sequences from vesicular stomatitis virus, which is considered a prototype RNA virus quasispecies. Our results are relevant to the evolution of RNA systems in general.

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More information

Published date: June 2001
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 352723
URI: https://eprints.soton.ac.uk/id/eprint/352723
PURE UUID: 168d206e-4650-4a4a-9bf7-11e441bc484a

Catalogue record

Date deposited: 23 May 2013 14:28
Last modified: 18 Jul 2017 04:12

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