Increased positive selection pressure in persistent (SSPE) versus acute measles virus infections
Increased positive selection pressure in persistent (SSPE) versus acute measles virus infections
We compared the extent of positive selection acting on acute and persistent strains of measles virus (MV). Far stronger positive selection was found in the fusion (F) and haemagglutinin (H) genes from subacute sclerosing panencephalitis (SSPE) compared to acute MV cases. Most of the positively selected sites identified in these surface glycoprotein genes from SSPE cases correspond to structural, functional or antigenic areas, and could not be explained by the effects of cell passaging. The correlations between selected sites and functional studies of MV are discussed in detail with reference to the maintenance of persistent infection. No positive selection was found in the matrix (M) gene from acute cases of MV and the effects of including hypermutated SSPE M gene sequences in phylogenetic inference were also explored. Finally, using H gene data, we estimated the rate of molecular evolution for SSPE strains as 3·4×10?4 substitutions/site/year, which is similar to previous estimates obtained for acute strains.
1419-1430
Woelk, C.H.
4d3af0fd-658f-4626-b3b5-49a6192bcf7d
Jin, L.
53827541-9b74-4222-b5ae-7d573e964b51
Brown, D.W.G.
d7c72ab9-ed0f-45fa-a0d9-9e7f111cc100
Holmes, E.C.
3679de5a-adee-49d6-9605-62c5016c8c26
June 2002
Woelk, C.H.
4d3af0fd-658f-4626-b3b5-49a6192bcf7d
Jin, L.
53827541-9b74-4222-b5ae-7d573e964b51
Brown, D.W.G.
d7c72ab9-ed0f-45fa-a0d9-9e7f111cc100
Holmes, E.C.
3679de5a-adee-49d6-9605-62c5016c8c26
Woelk, C.H., Jin, L., Brown, D.W.G. and Holmes, E.C.
(2002)
Increased positive selection pressure in persistent (SSPE) versus acute measles virus infections.
Journal of General Virology, 83 (6), .
Abstract
We compared the extent of positive selection acting on acute and persistent strains of measles virus (MV). Far stronger positive selection was found in the fusion (F) and haemagglutinin (H) genes from subacute sclerosing panencephalitis (SSPE) compared to acute MV cases. Most of the positively selected sites identified in these surface glycoprotein genes from SSPE cases correspond to structural, functional or antigenic areas, and could not be explained by the effects of cell passaging. The correlations between selected sites and functional studies of MV are discussed in detail with reference to the maintenance of persistent infection. No positive selection was found in the matrix (M) gene from acute cases of MV and the effects of including hypermutated SSPE M gene sequences in phylogenetic inference were also explored. Finally, using H gene data, we estimated the rate of molecular evolution for SSPE strains as 3·4×10?4 substitutions/site/year, which is similar to previous estimates obtained for acute strains.
This record has no associated files available for download.
More information
Published date: June 2002
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 352727
URI: http://eprints.soton.ac.uk/id/eprint/352727
ISSN: 0022-1317
PURE UUID: e4799a7d-dd16-496c-acec-d7f1c998be27
Catalogue record
Date deposited: 04 Jun 2013 13:55
Last modified: 22 Jul 2022 18:32
Export record
Contributors
Author:
C.H. Woelk
Author:
L. Jin
Author:
D.W.G. Brown
Author:
E.C. Holmes
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics