Interferon gene expression following HIV-1 infection of monocyte-derived macrophages

Woelk, C.H., Ottones, F., Plotkin, C.R., Pinyi, D., Royer, C.D., Rought, S.E., Lozach, J., Sasik, R., Kornbluth, R.S., Richman, D. and Corbeil, J. (2004) Interferon gene expression following HIV-1 infection of monocyte-derived macrophages. AIDS Research and Human Retroviruses, 20 (11), 1210-1222. (doi:10.1089/aid.2004.20.1210).

Abstract

Macrophages represent one of the primary targets of HIV-1 infection. Changes in gene expression in primary human monocyte-derived macrophages following virus exposure were assessed using oligonucleotide arrays. Over a third of the 100 most modulated genes belonged to the interferon system. Upregulated interferon-stimulated genes included those essential for the innate immune response and also those involved in interferon and virus signal transduction from the cell surface. The promoter regions of a cluster of highly upregulated interferon-stimulated genes were analyzed for common regulatory elements. The nuclear factor in activated T cells (NFAT) and members of the interferon family of transcription factors appeared to be responsible for the upregulation of this set of interferon-stimulated genes following HIV-1 exposure.

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