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Interferon gene expression following HIV-1 infection of monocyte-derived macrophages

Interferon gene expression following HIV-1 infection of monocyte-derived macrophages
Interferon gene expression following HIV-1 infection of monocyte-derived macrophages
Macrophages represent one of the primary targets of HIV-1 infection. Changes in gene expression in primary human monocyte-derived macrophages following virus exposure were assessed using oligonucleotide arrays. Over a third of the 100 most modulated genes belonged to the interferon system. Upregulated interferon-stimulated genes included those essential for the innate immune response and also those involved in interferon and virus signal transduction from the cell surface. The promoter regions of a cluster of highly upregulated interferon-stimulated genes were analyzed for common regulatory elements. The nuclear factor in activated T cells (NFAT) and members of the interferon family of transcription factors appeared to be responsible for the upregulation of this set of interferon-stimulated genes following HIV-1 exposure.
0889-2229
1210-1222
Woelk, C.H.
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Ottones, F.
3da20a78-9e69-4830-9bd1-6bde9cbdcb90
Plotkin, C.R.
624b7112-93ca-4b26-97b7-5358a710af72
Pinyi, D.
5468182d-b199-4d64-bfd1-f568b9c254c0
Royer, C.D.
dc058b5f-75db-4e3a-83f5-c8d95815db85
Rought, S.E.
e0f29ac0-6446-43c9-89db-293ee2e21c76
Lozach, J.
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Sasik, R.
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Kornbluth, R.S.
a32299ec-b1e5-40ea-9a76-571c412e0f8b
Richman, D.
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Corbeil, J.
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Woelk, C.H.
4d3af0fd-658f-4626-b3b5-49a6192bcf7d
Ottones, F.
3da20a78-9e69-4830-9bd1-6bde9cbdcb90
Plotkin, C.R.
624b7112-93ca-4b26-97b7-5358a710af72
Pinyi, D.
5468182d-b199-4d64-bfd1-f568b9c254c0
Royer, C.D.
dc058b5f-75db-4e3a-83f5-c8d95815db85
Rought, S.E.
e0f29ac0-6446-43c9-89db-293ee2e21c76
Lozach, J.
22cca36d-edb9-479c-87e2-0924423d80eb
Sasik, R.
0fcedc6c-8b27-4d07-8e59-d5148f2faad6
Kornbluth, R.S.
a32299ec-b1e5-40ea-9a76-571c412e0f8b
Richman, D.
4cf66dde-61e8-4aea-8720-7ca055f7a160
Corbeil, J.
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Woelk, C.H., Ottones, F., Plotkin, C.R., Pinyi, D., Royer, C.D., Rought, S.E., Lozach, J., Sasik, R., Kornbluth, R.S., Richman, D. and Corbeil, J. (2004) Interferon gene expression following HIV-1 infection of monocyte-derived macrophages. AIDS Research and Human Retroviruses, 20 (11), 1210-1222. (doi:10.1089/aid.2004.20.1210).

Record type: Article

Abstract

Macrophages represent one of the primary targets of HIV-1 infection. Changes in gene expression in primary human monocyte-derived macrophages following virus exposure were assessed using oligonucleotide arrays. Over a third of the 100 most modulated genes belonged to the interferon system. Upregulated interferon-stimulated genes included those essential for the innate immune response and also those involved in interferon and virus signal transduction from the cell surface. The promoter regions of a cluster of highly upregulated interferon-stimulated genes were analyzed for common regulatory elements. The nuclear factor in activated T cells (NFAT) and members of the interferon family of transcription factors appeared to be responsible for the upregulation of this set of interferon-stimulated genes following HIV-1 exposure.

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Published date: November 2004
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 352760
URI: https://eprints.soton.ac.uk/id/eprint/352760
ISSN: 0889-2229
PURE UUID: 90f89a3d-53f9-4ec0-9ccc-bebe371e46a9

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Date deposited: 04 Jun 2013 14:55
Last modified: 18 Jul 2017 04:11

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Contributors

Author: C.H. Woelk
Author: F. Ottones
Author: C.R. Plotkin
Author: D. Pinyi
Author: C.D. Royer
Author: S.E. Rought
Author: J. Lozach
Author: R. Sasik
Author: R.S. Kornbluth
Author: D. Richman
Author: J. Corbeil

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