Controlled, parametric, individualized, 2-D and 3-D imaging measurements of aerosol deposition in the respiratory tract of healthy human subjects: preliminary comparisons with simulations

Abstract

Preliminary comparisons of simulation results from existing extrathoracic (ET) models and a lung deposition model with individualized, two-dimensional and three-dimensional (3D) imaging measurements of aerosol deposition in the respiratory tract of healthy human subjects have been presented. In general, the ET models did not correspond well with each individual's experimental data. However, there is rather good agreement between simulated and experimental results for regional lung deposition comparable to those previously found in the literature. Comparisons of generational distributions are relatively poor. These preliminary results suggest not only the need for further developments in deposition modeling, but also the need for better methods for analyzing experimentally determined 3D deposition distributions for comparison to simulated results.

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ORCID for Joy H. Conway: orcid.org/0000-0001-6464-1526

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