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Model-based optimization of temperature and feed control strategies for glycerol production by fed-batch culture of osmophilic yeast Candida krusei

Model-based optimization of temperature and feed control strategies for glycerol production by fed-batch culture of osmophilic yeast Candida krusei
Model-based optimization of temperature and feed control strategies for glycerol production by fed-batch culture of osmophilic yeast Candida krusei
In this study, the optimization of temperature and feed control strategies for glycerol production by fed-batch culture of osmophilic yeast Candida krusei was investigated to maximize the final yield whilst to control the residual glucose at a low concentration. For the purposes of convenient control performance and easy numerical solution, the entire fermentation process was proposed being divided into multi-subintervals. In each subinterval, temperature was controlled constantly; while glucose and corn steep liquor were fed in pulse form at each start. Both piecewise-constant temperature (PCT) and discrete-pulse feed (DPF) control strategies were optimized by the complex method of Box based on previous macro-kinetic model and verified experimentally in a 600 ml airlift loop reactor. It was found that, by model-based optimization of only DPF control strategies, the final glycerol yield were significantly improved compared with those by previous empirical strategies. The yield could be improved further by optimization of both PCT and DPF control strategies and by selecting the first half of the whole fermentation process as the control emphasis. The optimization approach proposed appeared promising to solve the multivariable control problem in many fermentation processes.

glycerol, fermentation, temperature, fed-batch culture, optimization, kinetic model
1369-703X
111-121
Xie, Dong-Ming
fd851497-eb04-4f9e-bcab-beb0a6123275
Liu, De-Hua
45f49c30-2aaf-4f4f-9110-b3d8cbfadf73
Zhu, Hao-Li
dbd4b4c0-3c77-4fd8-a859-ec0a52c14ea8
Liu, Yong-Qiang
75adc6f8-aa83-484e-9e87-6c8442e344fa
Zhang, Jian-An
dba418d1-63cc-4d69-8371-fc0d004b70da
Xie, Dong-Ming
fd851497-eb04-4f9e-bcab-beb0a6123275
Liu, De-Hua
45f49c30-2aaf-4f4f-9110-b3d8cbfadf73
Zhu, Hao-Li
dbd4b4c0-3c77-4fd8-a859-ec0a52c14ea8
Liu, Yong-Qiang
75adc6f8-aa83-484e-9e87-6c8442e344fa
Zhang, Jian-An
dba418d1-63cc-4d69-8371-fc0d004b70da

Xie, Dong-Ming, Liu, De-Hua, Zhu, Hao-Li, Liu, Yong-Qiang and Zhang, Jian-An (2002) Model-based optimization of temperature and feed control strategies for glycerol production by fed-batch culture of osmophilic yeast Candida krusei. Biochemical Engineering Journal, 11 (2-3), 111-121. (doi:10.1016/S1369-703X(02)00015-3).

Record type: Article

Abstract

In this study, the optimization of temperature and feed control strategies for glycerol production by fed-batch culture of osmophilic yeast Candida krusei was investigated to maximize the final yield whilst to control the residual glucose at a low concentration. For the purposes of convenient control performance and easy numerical solution, the entire fermentation process was proposed being divided into multi-subintervals. In each subinterval, temperature was controlled constantly; while glucose and corn steep liquor were fed in pulse form at each start. Both piecewise-constant temperature (PCT) and discrete-pulse feed (DPF) control strategies were optimized by the complex method of Box based on previous macro-kinetic model and verified experimentally in a 600 ml airlift loop reactor. It was found that, by model-based optimization of only DPF control strategies, the final glycerol yield were significantly improved compared with those by previous empirical strategies. The yield could be improved further by optimization of both PCT and DPF control strategies and by selecting the first half of the whole fermentation process as the control emphasis. The optimization approach proposed appeared promising to solve the multivariable control problem in many fermentation processes.

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More information

Published date: September 2002
Keywords: glycerol, fermentation, temperature, fed-batch culture, optimization, kinetic model
Organisations: Water & Environmental Engineering Group

Identifiers

Local EPrints ID: 352846
URI: http://eprints.soton.ac.uk/id/eprint/352846
ISSN: 1369-703X
PURE UUID: becd723a-b903-40b5-b88a-842a87d581e8
ORCID for Yong-Qiang Liu: ORCID iD orcid.org/0000-0001-9688-1786

Catalogue record

Date deposited: 17 Jun 2013 15:34
Last modified: 15 Mar 2024 03:47

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Contributors

Author: Dong-Ming Xie
Author: De-Hua Liu
Author: Hao-Li Zhu
Author: Yong-Qiang Liu ORCID iD
Author: Jian-An Zhang

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