Regulation of lung surfactant phospholipid synthesis and metabolism
Regulation of lung surfactant phospholipid synthesis and metabolism
The alveolar type II epithelial (ATII) cell is highly specialised for the synthesis and storage, in intracellular lamellar bodies, of phospholipid destined for secretion as pulmonary surfactant into the alveolus. Regulation of the enzymology of surfactant phospholipid synthesis and metabolism has been extensively characterised at both molecular and functional levels, but understanding of surfactant phospholipid metabolism in vivo in either healthy or, especially, diseased lungs is still relatively poorly understood. This review will integrate recent advances in the enzymology of surfactant phospholipid metabolism with metabolic studies in vivo in both experimental animals and human subjects. It will highlight developments in the application of stable isotope-labelled precursor substrates and mass spectrometry to probe lung phospholipid metabolism in terms of individual molecular lipid species and identify areas where a more comprehensive metabolic model would have considerable potential for direct application to disease states.
448-458
Goss, Victoria
ef02be5d-9318-4f7d-b076-3153555980d0
Hunt, Alan N.
95a3e223-da96-40e7-b47d-27dce014e305
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Goss, Victoria
ef02be5d-9318-4f7d-b076-3153555980d0
Hunt, Alan N.
95a3e223-da96-40e7-b47d-27dce014e305
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Goss, Victoria, Hunt, Alan N. and Postle, Anthony D.
(2012)
Regulation of lung surfactant phospholipid synthesis and metabolism.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1831 (2), .
(doi:10.1016/j.bbalip.2012.11.009).
(PMID:23200861)
Abstract
The alveolar type II epithelial (ATII) cell is highly specialised for the synthesis and storage, in intracellular lamellar bodies, of phospholipid destined for secretion as pulmonary surfactant into the alveolus. Regulation of the enzymology of surfactant phospholipid synthesis and metabolism has been extensively characterised at both molecular and functional levels, but understanding of surfactant phospholipid metabolism in vivo in either healthy or, especially, diseased lungs is still relatively poorly understood. This review will integrate recent advances in the enzymology of surfactant phospholipid metabolism with metabolic studies in vivo in both experimental animals and human subjects. It will highlight developments in the application of stable isotope-labelled precursor substrates and mass spectrometry to probe lung phospholipid metabolism in terms of individual molecular lipid species and identify areas where a more comprehensive metabolic model would have considerable potential for direct application to disease states.
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e-pub ahead of print date: 27 November 2012
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 353063
URI: http://eprints.soton.ac.uk/id/eprint/353063
ISSN: 1388-1981
PURE UUID: 43b99d68-f14c-44c5-8a35-7e0d27830593
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Date deposited: 28 May 2013 15:04
Last modified: 15 Mar 2024 02:49
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Author:
Victoria Goss
Author:
Alan N. Hunt
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