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Percutaneous cryoablation of renal tumours: outcomes from 171 tumours in 147 patients

Percutaneous cryoablation of renal tumours: outcomes from 171 tumours in 147 patients
Percutaneous cryoablation of renal tumours: outcomes from 171 tumours in 147 patients
Objective: To evaluate the technical and oncological efficacy of an image-guided cryoablation programme for renal tumours.

Patients and Methods: A prospective analysis of technical and radiological outcomes was undertaken after treatment of 171 consecutive tumours in 147 patients. Oncological efficacy in a subset of 125 tumours in 104 patients with >6 months' radiological follow-up and a further subset of 62 patients with solitary, biopsy-proven renal carcinoma was also analysed. Factors influencing technical success, as determined by imaging follow-up, and complication rates were statistically analysed using a statistics software package and logistic regression analyses.

Results: No variables were found to predict subtotal treatment, although gender (P = 0.08), tumour size of >4?cm (P = 0.09) and central location of tumour (P = 0.07) approached significance. Upper pole location was the single variable that was found to predict complications (P = 0.006). Among the 104 patients (125 tumours), radiologically assessed at ?6 months and with a mean radiological follow-up of 20.1 months, we found a single case of unexpected late local recurrence.

Conclusion: Percutaneous image-guided cryoablation, at a mean of 20.1 months' follow-up, appears to provide a safe and effective treatment option with a low complication rate. Anteriorly sited tumours should not be considered a contraindication for percutaneous image-guided cryoablation.
1464-410X
758-765
Breen, D.J.
ae7bcf3b-188e-42a3-9c8d-9d2ff31dc2d6
Bryant, T.
6cc3c2b2-6dd5-46fc-bbf7-496f4e3483d8
Abbas, A.
465fff33-5fd0-47ab-9761-b0dab99661d5
Shepherd, B.
7026c206-f16d-4388-9231-db88860485c4
McGill, N.
d5809658-5226-4fac-b790-3d5cb018e481
Anderson, J.
a8c59b71-26f6-4ffc-86ea-590411509a9f
Lockyer, R.
a220a677-5427-4d60-a0ad-48e9f6b7a928
Hayes, M.
5fc8ef86-8177-4305-ada4-4dd85174ec43
George, S.
bdfc752b-f67e-4490-8dc0-99bfaeb046ca
Breen, D.J.
ae7bcf3b-188e-42a3-9c8d-9d2ff31dc2d6
Bryant, T.
6cc3c2b2-6dd5-46fc-bbf7-496f4e3483d8
Abbas, A.
465fff33-5fd0-47ab-9761-b0dab99661d5
Shepherd, B.
7026c206-f16d-4388-9231-db88860485c4
McGill, N.
d5809658-5226-4fac-b790-3d5cb018e481
Anderson, J.
a8c59b71-26f6-4ffc-86ea-590411509a9f
Lockyer, R.
a220a677-5427-4d60-a0ad-48e9f6b7a928
Hayes, M.
5fc8ef86-8177-4305-ada4-4dd85174ec43
George, S.
bdfc752b-f67e-4490-8dc0-99bfaeb046ca

Breen, D.J., Bryant, T., Abbas, A., Shepherd, B., McGill, N., Anderson, J., Lockyer, R., Hayes, M. and George, S. (2013) Percutaneous cryoablation of renal tumours: outcomes from 171 tumours in 147 patients. BJU International, 112, 758-765. (doi:10.1111/bju.12122). (PMID:23581293)

Record type: Article

Abstract

Objective: To evaluate the technical and oncological efficacy of an image-guided cryoablation programme for renal tumours.

Patients and Methods: A prospective analysis of technical and radiological outcomes was undertaken after treatment of 171 consecutive tumours in 147 patients. Oncological efficacy in a subset of 125 tumours in 104 patients with >6 months' radiological follow-up and a further subset of 62 patients with solitary, biopsy-proven renal carcinoma was also analysed. Factors influencing technical success, as determined by imaging follow-up, and complication rates were statistically analysed using a statistics software package and logistic regression analyses.

Results: No variables were found to predict subtotal treatment, although gender (P = 0.08), tumour size of >4?cm (P = 0.09) and central location of tumour (P = 0.07) approached significance. Upper pole location was the single variable that was found to predict complications (P = 0.006). Among the 104 patients (125 tumours), radiologically assessed at ?6 months and with a mean radiological follow-up of 20.1 months, we found a single case of unexpected late local recurrence.

Conclusion: Percutaneous image-guided cryoablation, at a mean of 20.1 months' follow-up, appears to provide a safe and effective treatment option with a low complication rate. Anteriorly sited tumours should not be considered a contraindication for percutaneous image-guided cryoablation.

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More information

e-pub ahead of print date: 12 April 2013
Published date: 2013
Organisations: Faculty of Medicine, Primary Care & Population Sciences

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Local EPrints ID: 353195
URI: https://eprints.soton.ac.uk/id/eprint/353195
ISSN: 1464-410X
PURE UUID: 7226b7ca-1098-4838-8836-9e38108f31f7

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Date deposited: 03 Jun 2013 13:09
Last modified: 16 Jul 2019 21:32

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