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Immune factors and fatty acid composition in human milk from river/lake, coastal and inland regions of China

Immune factors and fatty acid composition in human milk from river/lake, coastal and inland regions of China
Immune factors and fatty acid composition in human milk from river/lake, coastal and inland regions of China
Breast milk fatty acid composition may be affected by the maternal diet during gestation and lactation. The influence of dietary and breast milk fatty acids on breast milk immune factors is poorly defined. We determined the fatty acid composition and immune factor concentrations of breast milk from women residing in river/lake, coastal and inland regions of China, which differ in their consumption of lean fish and oily fish. Breast milk samples were collected on days 3–5 (colostrum), 14 and 28 post-partum (PP) and analysed for soluble CD14 (sCD14), transforming growth factor (TGF)-b1, TGF-b2, secretory IgA (sIgA) and fatty acids. The fatty acid composition of breast milk differed between the regions and with time PP. The concentrations of all four immune factors in breast milk decreased over time, with sCD14, sIgA and TGF-b1 being highest in the colostrum in the river and lake region. Breast milk DHA and arachidonic acid (AA) were positively associated, and g-linolenic acid and EPA negatively associated, with the concentrations of each of the four immune factors. In conclusion, breast milk fatty acids and immune factors differ between the regions in China characterised by different patterns of fish consumption and change during the course of lactation. A higher breast milk DHA and AA concentration is associated with higher concentrations of immune factors in breast milk, suggesting a role for these fatty acids in promoting gastrointestinal and immune maturation of the infant.
breast milk, DHA, transforming growth factor b, secretory IgA, soluble CD14
0007-1145
1949-1961
Urwin, Heidi
3efd37e0-fa35-43c1-acc0-141379d74e85
Zhang, Jian
a63c1b0a-6207-4dea-b5a2-bdbcd5c2024f
Gao, Yixong
d1166b55-7ebf-4f13-99fa-95711c56f7c4
Wang, Chunrong
30f3d74d-a0b4-4745-aba2-02705dbdf17c
Li, Lixiang
321eab71-4318-4e69-9b67-f08f3cd30b1c
Song, Pengkun
f4dd60af-bcb8-42c7-b12a-f11ecbea8ea1
Man, Qingqing
e083d8e8-8f9e-480a-bef2-44c0d697fca7
Meng, Lipeng
7a770661-f082-4eb8-b9ca-0d824ca45b09
Frøyland, Livar
5c47e80f-f1b7-4874-a384-815bbe92e0c0
Miles, Elizabeth A.
20332899-ecdb-4214-95bc-922dde36d416
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Yaqoob, Parveen
3a418e24-bbf0-4b31-9df8-ca8514885c82
Urwin, Heidi
3efd37e0-fa35-43c1-acc0-141379d74e85
Zhang, Jian
a63c1b0a-6207-4dea-b5a2-bdbcd5c2024f
Gao, Yixong
d1166b55-7ebf-4f13-99fa-95711c56f7c4
Wang, Chunrong
30f3d74d-a0b4-4745-aba2-02705dbdf17c
Li, Lixiang
321eab71-4318-4e69-9b67-f08f3cd30b1c
Song, Pengkun
f4dd60af-bcb8-42c7-b12a-f11ecbea8ea1
Man, Qingqing
e083d8e8-8f9e-480a-bef2-44c0d697fca7
Meng, Lipeng
7a770661-f082-4eb8-b9ca-0d824ca45b09
Frøyland, Livar
5c47e80f-f1b7-4874-a384-815bbe92e0c0
Miles, Elizabeth A.
20332899-ecdb-4214-95bc-922dde36d416
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Yaqoob, Parveen
3a418e24-bbf0-4b31-9df8-ca8514885c82

Urwin, Heidi, Zhang, Jian, Gao, Yixong, Wang, Chunrong, Li, Lixiang, Song, Pengkun, Man, Qingqing, Meng, Lipeng, Frøyland, Livar, Miles, Elizabeth A., Calder, Philip C. and Yaqoob, Parveen (2013) Immune factors and fatty acid composition in human milk from river/lake, coastal and inland regions of China. British Journal of Nutrition, 109 (11), 1949-1961. (doi:10.1017/S0007114512004084). (PMID:23148871)

Record type: Article

Abstract

Breast milk fatty acid composition may be affected by the maternal diet during gestation and lactation. The influence of dietary and breast milk fatty acids on breast milk immune factors is poorly defined. We determined the fatty acid composition and immune factor concentrations of breast milk from women residing in river/lake, coastal and inland regions of China, which differ in their consumption of lean fish and oily fish. Breast milk samples were collected on days 3–5 (colostrum), 14 and 28 post-partum (PP) and analysed for soluble CD14 (sCD14), transforming growth factor (TGF)-b1, TGF-b2, secretory IgA (sIgA) and fatty acids. The fatty acid composition of breast milk differed between the regions and with time PP. The concentrations of all four immune factors in breast milk decreased over time, with sCD14, sIgA and TGF-b1 being highest in the colostrum in the river and lake region. Breast milk DHA and arachidonic acid (AA) were positively associated, and g-linolenic acid and EPA negatively associated, with the concentrations of each of the four immune factors. In conclusion, breast milk fatty acids and immune factors differ between the regions in China characterised by different patterns of fish consumption and change during the course of lactation. A higher breast milk DHA and AA concentration is associated with higher concentrations of immune factors in breast milk, suggesting a role for these fatty acids in promoting gastrointestinal and immune maturation of the infant.

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More information

e-pub ahead of print date: 13 December 2012
Published date: June 2013
Keywords: breast milk, DHA, transforming growth factor b, secretory IgA, soluble CD14
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 353490
URI: http://eprints.soton.ac.uk/id/eprint/353490
ISSN: 0007-1145
PURE UUID: c2a57780-3aca-4e67-b4ed-038e37883043
ORCID for Elizabeth A. Miles: ORCID iD orcid.org/0000-0002-8643-0655
ORCID for Philip C. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 07 Jun 2013 15:14
Last modified: 10 Jan 2022 02:38

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Contributors

Author: Heidi Urwin
Author: Jian Zhang
Author: Yixong Gao
Author: Chunrong Wang
Author: Lixiang Li
Author: Pengkun Song
Author: Qingqing Man
Author: Lipeng Meng
Author: Livar Frøyland
Author: Parveen Yaqoob

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