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Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases

Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases
Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases
BACKGROUND: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are functionally the most important omega-3 polyunsaturated fatty acids (PUFAs). Oral supply of these fatty acids increases their levels in plasma and cell membranes, often at the expense of the omega-6 PUFAs arachidonic acid (ARA) and linoleic acid. This results in an altered pattern of lipid mediator production to one which is less pro-inflammatory. We investigated whether short term intravenous supply of omega-3 PUFAs could change the levels of EPA, DHA, ARA and linoleic acid in plasma and erythrocytes in patients with hepatic colorectal metastases.

METHODS: Twenty patients were randomised to receive a 72 hour infusion of total parenteral nutrition with (treatment group) or without (control group) omega-3 PUFAs. EPA, DHA, ARA and linoleic acid were measured in plasma phosphatidylcholine (PC) and erythrocytes at several times points up to the end of infusion and 5 to 12 days (mean 9 days) after stopping the infusion.

RESULTS: The treatment group showed increases in plasma PC EPA and DHA and erythrocyte EPA and decreases in plasma PC and erythrocyte linoleic acid, with effects most evident late in the infusion period. Plasma PC and erythrocyte EPA and linoleic acid all returned to baseline levels after the 5-12 day washout. Plasma PC DHA remained elevated above baseline after washout.

CONCLUSIONS: Intravenous supply of omega-3 PUFAs results in a rapid increase of EPA and DHA in plasma PC and of EPA in erythrocytes. These findings suggest that infusion of omega-3 PUFAs could be used to induce a rapid effect especially in targeting inflammation.
parenteral nutrition, fish oil, omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, liver metastases
Al-Taan, Omer
0b963b40-5315-4a85-a005-189e5e01987f
Stephenson, James A.
16b29e75-cc40-4407-a885-21d80426607c
Spencer, Laura
f4a14765-5961-4fe7-a032-5afea427204b
Pollard, Cristina
8500df33-7b13-4ed9-aae6-913949842fc2
West, Annette L.
e8dacc1a-5fdc-4a4f-92d8-608f2ea2994c
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Metcalfe, Matthew
a9f7f6a2-32f4-470e-96e2-49156f214b31
Dennison, Ashley R.
a1272efe-98b9-4807-8a4e-603b85927e4c
Al-Taan, Omer
0b963b40-5315-4a85-a005-189e5e01987f
Stephenson, James A.
16b29e75-cc40-4407-a885-21d80426607c
Spencer, Laura
f4a14765-5961-4fe7-a032-5afea427204b
Pollard, Cristina
8500df33-7b13-4ed9-aae6-913949842fc2
West, Annette L.
e8dacc1a-5fdc-4a4f-92d8-608f2ea2994c
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Metcalfe, Matthew
a9f7f6a2-32f4-470e-96e2-49156f214b31
Dennison, Ashley R.
a1272efe-98b9-4807-8a4e-603b85927e4c

Al-Taan, Omer, Stephenson, James A., Spencer, Laura, Pollard, Cristina, West, Annette L., Calder, P.C., Metcalfe, Matthew and Dennison, Ashley R. (2013) Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. Lipids in Health and Disease, 12 (64). (doi:10.1186/1476-511X-12-64). (PMID:23648075)

Record type: Article

Abstract

BACKGROUND: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are functionally the most important omega-3 polyunsaturated fatty acids (PUFAs). Oral supply of these fatty acids increases their levels in plasma and cell membranes, often at the expense of the omega-6 PUFAs arachidonic acid (ARA) and linoleic acid. This results in an altered pattern of lipid mediator production to one which is less pro-inflammatory. We investigated whether short term intravenous supply of omega-3 PUFAs could change the levels of EPA, DHA, ARA and linoleic acid in plasma and erythrocytes in patients with hepatic colorectal metastases.

METHODS: Twenty patients were randomised to receive a 72 hour infusion of total parenteral nutrition with (treatment group) or without (control group) omega-3 PUFAs. EPA, DHA, ARA and linoleic acid were measured in plasma phosphatidylcholine (PC) and erythrocytes at several times points up to the end of infusion and 5 to 12 days (mean 9 days) after stopping the infusion.

RESULTS: The treatment group showed increases in plasma PC EPA and DHA and erythrocyte EPA and decreases in plasma PC and erythrocyte linoleic acid, with effects most evident late in the infusion period. Plasma PC and erythrocyte EPA and linoleic acid all returned to baseline levels after the 5-12 day washout. Plasma PC DHA remained elevated above baseline after washout.

CONCLUSIONS: Intravenous supply of omega-3 PUFAs results in a rapid increase of EPA and DHA in plasma PC and of EPA in erythrocytes. These findings suggest that infusion of omega-3 PUFAs could be used to induce a rapid effect especially in targeting inflammation.

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Published date: 7 May 2013
Keywords: parenteral nutrition, fish oil, omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, liver metastases
Organisations: Human Development & Health

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Local EPrints ID: 353504
URI: https://eprints.soton.ac.uk/id/eprint/353504
PURE UUID: 9e593c4d-e427-4d49-bc96-7e4fab8326d8

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Date deposited: 07 Jun 2013 14:41
Last modified: 18 Jul 2017 04:03

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Contributors

Author: Omer Al-Taan
Author: James A. Stephenson
Author: Laura Spencer
Author: Cristina Pollard
Author: Annette L. West
Author: P.C. Calder
Author: Matthew Metcalfe
Author: Ashley R. Dennison

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