Distribution of carried pneumococcal clones in UK children following the introduction of the 7-valent pneumococcal conjugate vaccine: a 3-year cross-sectional population based analysis
Distribution of carried pneumococcal clones in UK children following the introduction of the 7-valent pneumococcal conjugate vaccine: a 3-year cross-sectional population based analysis
The success of Streptococcus pneumoniae (pneumococcus) in both colonisation and disease is associated with the increased prevalence of genetic clones expressing virulence factors that assist host invasion. We studied the distribution of pneumococcal clones in paediatric carriage as part of an ongoing longitudinal study of pneumococcal carriage in children less than 5 years of age. Across three years, 87 different sequence types (STs) were found amongst 310 pneumococci. A decline in PCV-7 related STs was observed during the study period. STs 62, 199, 433 and 1692 increased after the implementation of PCV-7 and were related to increases in serotypes 11A, 19A, 22F, and to serotype 6C, respectively. Overall, a strong correlation was observed between ST and serotype. Thirteen STs contained multiple serotypes and 74 STs were associated with only one serotype. On-going molecular epidemiological surveillance of pneumococcal carriage is warranted during the implementation of pneumococcal conjugate vaccines.
544-546
Tocheva, A.S.
84454eb2-8171-43b2-923c-54d224c7cde1
Jefferies, J.M.C.
9468e292-0b41-412d-9470-944e257c7bcf
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Faust, S.N.
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Clarke, Stuart C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Tocheva, A.S.
84454eb2-8171-43b2-923c-54d224c7cde1
Jefferies, J.M.C.
9468e292-0b41-412d-9470-944e257c7bcf
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Clarke, Stuart C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Tocheva, A.S., Jefferies, J.M.C., Christodoulides, Myron, Faust, S.N. and Clarke, Stuart C.
(2013)
Distribution of carried pneumococcal clones in UK children following the introduction of the 7-valent pneumococcal conjugate vaccine: a 3-year cross-sectional population based analysis.
Vaccine, 31 (31), .
(doi:10.1016/j.vaccine.2013.04.075).
(PMID:23680442)
Abstract
The success of Streptococcus pneumoniae (pneumococcus) in both colonisation and disease is associated with the increased prevalence of genetic clones expressing virulence factors that assist host invasion. We studied the distribution of pneumococcal clones in paediatric carriage as part of an ongoing longitudinal study of pneumococcal carriage in children less than 5 years of age. Across three years, 87 different sequence types (STs) were found amongst 310 pneumococci. A decline in PCV-7 related STs was observed during the study period. STs 62, 199, 433 and 1692 increased after the implementation of PCV-7 and were related to increases in serotypes 11A, 19A, 22F, and to serotype 6C, respectively. Overall, a strong correlation was observed between ST and serotype. Thirteen STs contained multiple serotypes and 74 STs were associated with only one serotype. On-going molecular epidemiological surveillance of pneumococcal carriage is warranted during the implementation of pneumococcal conjugate vaccines.
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e-pub ahead of print date: 13 May 2013
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Faculty of Medicine
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Local EPrints ID: 353509
URI: http://eprints.soton.ac.uk/id/eprint/353509
PURE UUID: 2457b771-49cb-48c4-9ed9-0881de6211f7
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Date deposited: 10 Jun 2013 11:54
Last modified: 15 Mar 2024 03:26
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Author:
A.S. Tocheva
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J.M.C. Jefferies
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