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Infant feeding options, other nonchemoprophylactic factors, and mother-to-child transmission of HIV in Zambia

Infant feeding options, other nonchemoprophylactic factors, and mother-to-child transmission of HIV in Zambia
Infant feeding options, other nonchemoprophylactic factors, and mother-to-child transmission of HIV in Zambia
BACKGROUND: The role of antiretroviral drugs in the prevention of mother-to-child transmission (PMTCT) of HIV is well known. The objective of this study is to explore how nonchemoprophylactic factors, including infant feeding practices, mother's HIV status disclosure, mode and place of delivery, infant gender, and maternal age, are related to MTCT.

METHODS: The study analyzed program data of DNA polymerase chain reaction (PCR) results from dried blood spot samples and selected client information from perinatally exposed infants aged 0 to 12 months.

RESULTS: A total of 8237 samples were analyzed. In all, 84% of the mothers ever breast-fed their children. In instances where both mother and baby received intervention, the transmission rates of HIV were higher among those who are still breast-feeding after 6 to 12 months. Disclosure, location, and mode of delivery did not have an effect on the transmission rates of HIV when both mother and baby received prophylaxis.

CONCLUSION: Nonchemoprophylaxis factors, especially breast-feeding, play a key role in perinatal transmission of HIV.
breast-feeding, disclosure, nonchemoprophylactic, prevention of mother-to-child transmission, zambia
1545-1097
26-33
Torpey, K.
1dee28b1-d9d8-41eb-a490-acba68f88772
Kabaso, M.
180b4c6b-f956-4d1e-a371-ea03917ad42a
Weaver, M.A.
f4544d65-b025-4be2-94b0-e81dca56f21c
Kasonde, P.
f08d6852-984e-4025-bc39-7034a9ab4519
Mukonka, V.
27a666df-0269-4617-8fef-0f1eeeccbc21
Bweupe, M.
bc4dd31b-8075-4c9d-af55-48bdeb787c0f
Mukundu, J.
7b16b77d-45c4-40ea-b77a-4bafd4516b9c
Mandala, J.
c8407ecb-6459-4332-96fa-73045f8cdb48
Torpey, K.
1dee28b1-d9d8-41eb-a490-acba68f88772
Kabaso, M.
180b4c6b-f956-4d1e-a371-ea03917ad42a
Weaver, M.A.
f4544d65-b025-4be2-94b0-e81dca56f21c
Kasonde, P.
f08d6852-984e-4025-bc39-7034a9ab4519
Mukonka, V.
27a666df-0269-4617-8fef-0f1eeeccbc21
Bweupe, M.
bc4dd31b-8075-4c9d-af55-48bdeb787c0f
Mukundu, J.
7b16b77d-45c4-40ea-b77a-4bafd4516b9c
Mandala, J.
c8407ecb-6459-4332-96fa-73045f8cdb48

Torpey, K., Kabaso, M., Weaver, M.A., Kasonde, P., Mukonka, V., Bweupe, M., Mukundu, J. and Mandala, J. (2012) Infant feeding options, other nonchemoprophylactic factors, and mother-to-child transmission of HIV in Zambia. Journal of the International Association of Physicians in AIDS Care (JIAPAC), 11 (1), 26-33. (doi:10.1177/1545109710393308). (PMID:21430237)

Record type: Article

Abstract

BACKGROUND: The role of antiretroviral drugs in the prevention of mother-to-child transmission (PMTCT) of HIV is well known. The objective of this study is to explore how nonchemoprophylactic factors, including infant feeding practices, mother's HIV status disclosure, mode and place of delivery, infant gender, and maternal age, are related to MTCT.

METHODS: The study analyzed program data of DNA polymerase chain reaction (PCR) results from dried blood spot samples and selected client information from perinatally exposed infants aged 0 to 12 months.

RESULTS: A total of 8237 samples were analyzed. In all, 84% of the mothers ever breast-fed their children. In instances where both mother and baby received intervention, the transmission rates of HIV were higher among those who are still breast-feeding after 6 to 12 months. Disclosure, location, and mode of delivery did not have an effect on the transmission rates of HIV when both mother and baby received prophylaxis.

CONCLUSION: Nonchemoprophylaxis factors, especially breast-feeding, play a key role in perinatal transmission of HIV.

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More information

e-pub ahead of print date: 23 March 2011
Published date: January 2012
Keywords: breast-feeding, disclosure, nonchemoprophylactic, prevention of mother-to-child transmission, zambia
Organisations: Mathematical Sciences

Identifiers

Local EPrints ID: 353687
URI: http://eprints.soton.ac.uk/id/eprint/353687
ISSN: 1545-1097
PURE UUID: 9c805042-13e5-4d4d-8aeb-0361a1e485af

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Date deposited: 13 Jun 2013 15:14
Last modified: 22 Jul 2022 18:34

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Contributors

Author: K. Torpey
Author: M. Kabaso
Author: M.A. Weaver
Author: P. Kasonde
Author: V. Mukonka
Author: M. Bweupe
Author: J. Mukundu
Author: J. Mandala

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