The University of Southampton
University of Southampton Institutional Repository

Patterns of multi-site pain and associations with risk factors

Patterns of multi-site pain and associations with risk factors
Patterns of multi-site pain and associations with risk factors
To explore definitions for multisite pain, and compare associations with risk factors for different patterns of musculoskeletal pain, we analysed cross-sectional data from the Cultural and Psychosocial Influences on Disability study. The study sample comprised 12,410 adults aged 20-59years from 47 occupational groups in 18 countries. A standardised questionnaire was used to collect information about pain in the past month at each of 10 anatomical sites, and about potential risk factors. Associations with pain outcomes were assessed by Poisson regression, and characterised by prevalence rate ratios (PRRs). Extensive pain, affecting 6-10 anatomical sites, was reported much more frequently than would be expected if the occurrence of pain at each site were independent (674 participants vs 41.9 expected). In comparison with pain involving only 1-3 sites, it showed much stronger associations (relative to no pain) with risk factors such as female sex (PRR 1.6 vs 1.1), older age (PRR 2.6 vs 1.1), somatising tendency (PRR 4.6 vs 1.3), and exposure to multiple physically stressing occupational activities (PRR 5.0 vs 1.4). After adjustment for number of sites with pain, these risk factors showed no additional association with a distribution of pain that was widespread according to the frequently used American College of Rheumatology criteria. Our analysis supports the classification of pain at multiple anatomical sites simply by the number of sites affected, and suggests that extensive pain differs importantly in its associations with risk factors from pain that is limited to only a small number of anatomical sites.

pain, multisite, widespread, definition, risk factors
0304-3959
1769-17777
Coggon, David
2b43ce0a-cc61-4d86-b15d-794208ffa5d3
Ntani, Georgia
9b009e0a-5ab2-4c6e-a9fd-15a601e92be5
Palmer, Keith T.
0cfe63f0-1d33-40ff-ae8c-6c33601df850
Felli, Vanda E.
0867cd3d-0302-410f-879a-1f19805f1f2d
Herari, Raul
168c46e5-6444-4559-b3f6-cf5405eaf291
Barrero, Lope H.
84489efa-70ea-429c-886f-5bd102d0169e
Felknor, Sarah A.
63e6422e-8b8e-449f-b0c4-5848eade3461
Gimeno, David
900ab17d-6066-444a-8ee7-c38f9fc3b419
Cattrell, Anna
c8488380-a9b5-47c1-a5ca-9d19b8aec227
Vargas-Prada, Sergio
c6b3de67-2eef-40e5-b2e8-7374a24ef097
Bonzini, Matteo
764e0306-7727-4c67-947b-1c4ccc8d08d7
Solidaki, Eleni
df3af6a8-3325-4a24-be83-9dd18fc1ebbe
Merisalu, Eda
577fb9bd-8613-483f-b257-e6e53a8201d4
Habib, Rima R.
88dd5af4-9029-476b-9658-13ebd0eaba21
Sadeghianm, Farideh
0ce25077-7c3a-433f-a88c-bd6fecbf312c
Kadir, M. Masood
aae852bc-0ca3-4614-a40b-fa6e78f971f4
Warnakulasuriya, Sudath S.P.
ee284470-135b-4b80-9167-7f710140bb63
Matsudaira, Ko
cf9a5c3c-2c69-463c-a16b-e17897845cc5
Nyantumbu, Busisiwe
5a7a65dc-72ce-48c2-b4e9-a91d9edcafbc
Sim, Malcolm R.
6d04f31c-e51a-4eef-8921-5c67ae30c4ef
Harcombe, Helen
aa5533fc-07a4-4432-ab36-10bd76b96ce7
Cox, Ken
1c71487b-d9a0-431c-9f6a-13e3589e5b21
Marziale, Maria H.
b23e3a97-7534-4c2b-a9c0-62cc8472602d
Sarquis, Leila M.
0d22ed72-15d8-4908-b391-ebdde5704334
Harari, Leila M.
ab9e3015-451d-41f8-b9eb-f390e7b9de25
Freire, Rocio
3f7df835-ba58-4cb8-88df-ba26963387e0
Harari, Natalia
6d08f9a1-a1f0-4045-affb-d1e1f772f577
Monroy, Magda V.
235f3cac-2e6e-4dd1-ac9e-6b9fdd22261b
Qintana, Leonardo A.
69011e05-e68d-4757-9644-073b03f264ba
Rojas, Marianela
7c1a12f4-db61-4179-bb9f-7a806ae8714f
Salazar Vega, Eduardo J.
f0a248b1-ed07-4932-a036-cc7c4fa4f1ee
Harris, Clare E
5cf60085-46ba-4387-919c-c9bd88a9fc6c
Serra, Consol
17669164-dd29-447e-94ba-1ef93918fcdb
Martinez, Miguel
991ce60a-ace9-4004-a101-bfcc88ed8878
Delclos, George
85d80fa6-5d3e-4916-a863-f0908643b3ce
Benavides, Fernando G.
c4682a90-6357-4430-ad28-2ba485429271
Carugno, Michele
d729cc2c-e9c4-4599-bade-1f59c4d77ff9
Ferrario, Marco M.
cc797bca-9ac4-4583-880f-ba62469d9459
Pesatori, Angela C.
2803b302-8e91-4f3c-9d95-90af4a4e8435
Chatzi, Leda
d120a7e6-1fe3-4ce9-8b2b-55ad9aa1c254
Bitsios, Panos
8bcb2abf-939e-4150-809d-fa9cbe51a6f8
Kogevinas, Manolis
3d3864dd-6986-4aba-bdbc-2119664d9165
Oha, Kristel
ae44ae08-77cb-428a-865a-3c06033e0573
Sirk, Tuuli
21a229a4-baaa-4cf7-bd20-ea17f83beedb
Sadeghian, Ali
70832238-806b-4c2d-afa6-00a4cbfedef6
Peiris-John, Roshini
6661abf7-58eb-43ad-8c2a-a01887cb6632
Sathiakumar, Nalini
40fa4e9d-5d7e-4e7e-be7f-76792adf75d9
Wickremasinghe, A. Rajitha
183b6b1b-aba2-430e-bea7-ad393f352d95
Yoshimura, Noriko
00436389-57b3-444c-b69d-0dc934d8e0d5
Kelsall, Helen L.
027e15f0-b24c-4fca-ac9c-8e5e8bee262a
Hoe, Victor C.W.
15cbc37f-4895-4a47-bd5e-49a57d577c2c
Urquhart, Donna M.
42534386-6ef5-48cf-a0d7-9237d6d9f78e
Derrett, Sarah
ab29f957-5956-4185-97bf-9d07644ca1dc
McBride, David
52f7c583-c8c6-45de-bdf7-e3bbe890662e
Herbison, Peter
b2c61b2c-177d-4b5a-839a-3f878b55bf6d
Gray, Andrew
4d853562-73e5-4240-a865-55262ddc9e5b
Coggon, David
2b43ce0a-cc61-4d86-b15d-794208ffa5d3
Ntani, Georgia
9b009e0a-5ab2-4c6e-a9fd-15a601e92be5
Palmer, Keith T.
0cfe63f0-1d33-40ff-ae8c-6c33601df850
Felli, Vanda E.
0867cd3d-0302-410f-879a-1f19805f1f2d
Herari, Raul
168c46e5-6444-4559-b3f6-cf5405eaf291
Barrero, Lope H.
84489efa-70ea-429c-886f-5bd102d0169e
Felknor, Sarah A.
63e6422e-8b8e-449f-b0c4-5848eade3461
Gimeno, David
900ab17d-6066-444a-8ee7-c38f9fc3b419
Cattrell, Anna
c8488380-a9b5-47c1-a5ca-9d19b8aec227
Vargas-Prada, Sergio
c6b3de67-2eef-40e5-b2e8-7374a24ef097
Bonzini, Matteo
764e0306-7727-4c67-947b-1c4ccc8d08d7
Solidaki, Eleni
df3af6a8-3325-4a24-be83-9dd18fc1ebbe
Merisalu, Eda
577fb9bd-8613-483f-b257-e6e53a8201d4
Habib, Rima R.
88dd5af4-9029-476b-9658-13ebd0eaba21
Sadeghianm, Farideh
0ce25077-7c3a-433f-a88c-bd6fecbf312c
Kadir, M. Masood
aae852bc-0ca3-4614-a40b-fa6e78f971f4
Warnakulasuriya, Sudath S.P.
ee284470-135b-4b80-9167-7f710140bb63
Matsudaira, Ko
cf9a5c3c-2c69-463c-a16b-e17897845cc5
Nyantumbu, Busisiwe
5a7a65dc-72ce-48c2-b4e9-a91d9edcafbc
Sim, Malcolm R.
6d04f31c-e51a-4eef-8921-5c67ae30c4ef
Harcombe, Helen
aa5533fc-07a4-4432-ab36-10bd76b96ce7
Cox, Ken
1c71487b-d9a0-431c-9f6a-13e3589e5b21
Marziale, Maria H.
b23e3a97-7534-4c2b-a9c0-62cc8472602d
Sarquis, Leila M.
0d22ed72-15d8-4908-b391-ebdde5704334
Harari, Leila M.
ab9e3015-451d-41f8-b9eb-f390e7b9de25
Freire, Rocio
3f7df835-ba58-4cb8-88df-ba26963387e0
Harari, Natalia
6d08f9a1-a1f0-4045-affb-d1e1f772f577
Monroy, Magda V.
235f3cac-2e6e-4dd1-ac9e-6b9fdd22261b
Qintana, Leonardo A.
69011e05-e68d-4757-9644-073b03f264ba
Rojas, Marianela
7c1a12f4-db61-4179-bb9f-7a806ae8714f
Salazar Vega, Eduardo J.
f0a248b1-ed07-4932-a036-cc7c4fa4f1ee
Harris, Clare E
5cf60085-46ba-4387-919c-c9bd88a9fc6c
Serra, Consol
17669164-dd29-447e-94ba-1ef93918fcdb
Martinez, Miguel
991ce60a-ace9-4004-a101-bfcc88ed8878
Delclos, George
85d80fa6-5d3e-4916-a863-f0908643b3ce
Benavides, Fernando G.
c4682a90-6357-4430-ad28-2ba485429271
Carugno, Michele
d729cc2c-e9c4-4599-bade-1f59c4d77ff9
Ferrario, Marco M.
cc797bca-9ac4-4583-880f-ba62469d9459
Pesatori, Angela C.
2803b302-8e91-4f3c-9d95-90af4a4e8435
Chatzi, Leda
d120a7e6-1fe3-4ce9-8b2b-55ad9aa1c254
Bitsios, Panos
8bcb2abf-939e-4150-809d-fa9cbe51a6f8
Kogevinas, Manolis
3d3864dd-6986-4aba-bdbc-2119664d9165
Oha, Kristel
ae44ae08-77cb-428a-865a-3c06033e0573
Sirk, Tuuli
21a229a4-baaa-4cf7-bd20-ea17f83beedb
Sadeghian, Ali
70832238-806b-4c2d-afa6-00a4cbfedef6
Peiris-John, Roshini
6661abf7-58eb-43ad-8c2a-a01887cb6632
Sathiakumar, Nalini
40fa4e9d-5d7e-4e7e-be7f-76792adf75d9
Wickremasinghe, A. Rajitha
183b6b1b-aba2-430e-bea7-ad393f352d95
Yoshimura, Noriko
00436389-57b3-444c-b69d-0dc934d8e0d5
Kelsall, Helen L.
027e15f0-b24c-4fca-ac9c-8e5e8bee262a
Hoe, Victor C.W.
15cbc37f-4895-4a47-bd5e-49a57d577c2c
Urquhart, Donna M.
42534386-6ef5-48cf-a0d7-9237d6d9f78e
Derrett, Sarah
ab29f957-5956-4185-97bf-9d07644ca1dc
McBride, David
52f7c583-c8c6-45de-bdf7-e3bbe890662e
Herbison, Peter
b2c61b2c-177d-4b5a-839a-3f878b55bf6d
Gray, Andrew
4d853562-73e5-4240-a865-55262ddc9e5b

Coggon, David, Ntani, Georgia, Palmer, Keith T., Felli, Vanda E., Herari, Raul, Barrero, Lope H., Felknor, Sarah A., Gimeno, David, Cattrell, Anna, Vargas-Prada, Sergio, Bonzini, Matteo, Solidaki, Eleni, Merisalu, Eda, Habib, Rima R., Sadeghianm, Farideh, Kadir, M. Masood, Warnakulasuriya, Sudath S.P., Matsudaira, Ko, Nyantumbu, Busisiwe, Sim, Malcolm R., Harcombe, Helen, Cox, Ken, Marziale, Maria H., Sarquis, Leila M., Harari, Leila M., Freire, Rocio, Harari, Natalia, Monroy, Magda V., Qintana, Leonardo A., Rojas, Marianela, Salazar Vega, Eduardo J., Harris, Clare E, Serra, Consol, Martinez, Miguel, Delclos, George, Benavides, Fernando G., Carugno, Michele, Ferrario, Marco M., Pesatori, Angela C., Chatzi, Leda, Bitsios, Panos, Kogevinas, Manolis, Oha, Kristel, Sirk, Tuuli, Sadeghian, Ali, Peiris-John, Roshini, Sathiakumar, Nalini, Wickremasinghe, A. Rajitha, Yoshimura, Noriko, Kelsall, Helen L., Hoe, Victor C.W., Urquhart, Donna M., Derrett, Sarah, McBride, David, Herbison, Peter and Gray, Andrew (2013) Patterns of multi-site pain and associations with risk factors. Pain, 154 (9), 1769-17777. (doi:10.1016/j.pain.2013.05.039). (PMID:23727463)

Record type: Article

Abstract

To explore definitions for multisite pain, and compare associations with risk factors for different patterns of musculoskeletal pain, we analysed cross-sectional data from the Cultural and Psychosocial Influences on Disability study. The study sample comprised 12,410 adults aged 20-59years from 47 occupational groups in 18 countries. A standardised questionnaire was used to collect information about pain in the past month at each of 10 anatomical sites, and about potential risk factors. Associations with pain outcomes were assessed by Poisson regression, and characterised by prevalence rate ratios (PRRs). Extensive pain, affecting 6-10 anatomical sites, was reported much more frequently than would be expected if the occurrence of pain at each site were independent (674 participants vs 41.9 expected). In comparison with pain involving only 1-3 sites, it showed much stronger associations (relative to no pain) with risk factors such as female sex (PRR 1.6 vs 1.1), older age (PRR 2.6 vs 1.1), somatising tendency (PRR 4.6 vs 1.3), and exposure to multiple physically stressing occupational activities (PRR 5.0 vs 1.4). After adjustment for number of sites with pain, these risk factors showed no additional association with a distribution of pain that was widespread according to the frequently used American College of Rheumatology criteria. Our analysis supports the classification of pain at multiple anatomical sites simply by the number of sites affected, and suggests that extensive pain differs importantly in its associations with risk factors from pain that is limited to only a small number of anatomical sites.

Other
1-s2.0-S0304395913002789-main.pdf__tid=56fe5b06-457d-11e4-92e4-00000aacb35f&acdnat=1411736716_c33a20792a65a0ceedc5376f4dafb811 - Version of Record
Available under License Other.
Download (381kB)

More information

Published date: September 2013
Keywords: pain, multisite, widespread, definition, risk factors
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 353731
URI: http://eprints.soton.ac.uk/id/eprint/353731
ISSN: 0304-3959
PURE UUID: 9c425732-791e-456c-ad5c-2e90809ec732
ORCID for David Coggon: ORCID iD orcid.org/0000-0003-1930-3987

Catalogue record

Date deposited: 14 Jun 2013 15:31
Last modified: 28 Oct 2023 01:41

Export record

Altmetrics

Contributors

Author: David Coggon ORCID iD
Author: Georgia Ntani
Author: Keith T. Palmer
Author: Vanda E. Felli
Author: Raul Herari
Author: Lope H. Barrero
Author: Sarah A. Felknor
Author: David Gimeno
Author: Anna Cattrell
Author: Sergio Vargas-Prada
Author: Matteo Bonzini
Author: Eleni Solidaki
Author: Eda Merisalu
Author: Rima R. Habib
Author: Farideh Sadeghianm
Author: M. Masood Kadir
Author: Sudath S.P. Warnakulasuriya
Author: Ko Matsudaira
Author: Busisiwe Nyantumbu
Author: Malcolm R. Sim
Author: Helen Harcombe
Author: Ken Cox
Author: Maria H. Marziale
Author: Leila M. Sarquis
Author: Leila M. Harari
Author: Rocio Freire
Author: Natalia Harari
Author: Magda V. Monroy
Author: Leonardo A. Qintana
Author: Marianela Rojas
Author: Eduardo J. Salazar Vega
Author: Clare E Harris
Author: Consol Serra
Author: Miguel Martinez
Author: George Delclos
Author: Fernando G. Benavides
Author: Michele Carugno
Author: Marco M. Ferrario
Author: Angela C. Pesatori
Author: Leda Chatzi
Author: Panos Bitsios
Author: Manolis Kogevinas
Author: Kristel Oha
Author: Tuuli Sirk
Author: Ali Sadeghian
Author: Roshini Peiris-John
Author: Nalini Sathiakumar
Author: A. Rajitha Wickremasinghe
Author: Noriko Yoshimura
Author: Helen L. Kelsall
Author: Victor C.W. Hoe
Author: Donna M. Urquhart
Author: Sarah Derrett
Author: David McBride
Author: Peter Herbison
Author: Andrew Gray

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×