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Identification of a novel t(7;14) translocation in multiple myeloma resulting in overexpression of EGFR

Identification of a novel t(7;14) translocation in multiple myeloma resulting in overexpression of EGFR
Identification of a novel t(7;14) translocation in multiple myeloma resulting in overexpression of EGFR
IGH translocations in myeloma are a primary event and determine the prognostic outcome of a patient. These events are characterized by FISH and classical cytogenetics, but in a small proportion of samples a translocation involving the IGH locus can be detected but the partner chromosome cannot be identified. These cases are usually genetically complex and are the result of cryptic events that cannot be discerned at the resolution of FISH. Here we analyzed a sample with an unidentified translocation partner using a targeted capture and massively parallel sequencing. We identified the partner chromosome as a t(7;14) with the breakpoint upstream of EGFR. This sample over-expresses the target oncogene, EGFR. This case represents a rare and novel translocation in myeloma, from which a targeted personalized treatment, in the form of EGFR inhibitors, which are commonly used in other cancer types, could be used.
1045-2257
817-822
Walker, Brian A.
7e45e107-ca85-4368-8673-7177f2328405
Wardell, Christopher P.
0d498cee-324b-457c-adff-7193c16cf2d5
Ross, Fiona M.
ec0958f8-b992-4e4a-b7e3-c474600390ba
Morgan, Gareth J.
d285dcf8-ac2c-4fe0-acf9-4787eb025939
Walker, Brian A.
7e45e107-ca85-4368-8673-7177f2328405
Wardell, Christopher P.
0d498cee-324b-457c-adff-7193c16cf2d5
Ross, Fiona M.
ec0958f8-b992-4e4a-b7e3-c474600390ba
Morgan, Gareth J.
d285dcf8-ac2c-4fe0-acf9-4787eb025939

Walker, Brian A., Wardell, Christopher P., Ross, Fiona M. and Morgan, Gareth J. (2013) Identification of a novel t(7;14) translocation in multiple myeloma resulting in overexpression of EGFR. Genes, Chromosomes and Cancer, 52 (9), 817-822. (doi:10.1002/gcc.22077).

Record type: Article

Abstract

IGH translocations in myeloma are a primary event and determine the prognostic outcome of a patient. These events are characterized by FISH and classical cytogenetics, but in a small proportion of samples a translocation involving the IGH locus can be detected but the partner chromosome cannot be identified. These cases are usually genetically complex and are the result of cryptic events that cannot be discerned at the resolution of FISH. Here we analyzed a sample with an unidentified translocation partner using a targeted capture and massively parallel sequencing. We identified the partner chromosome as a t(7;14) with the breakpoint upstream of EGFR. This sample over-expresses the target oncogene, EGFR. This case represents a rare and novel translocation in myeloma, from which a targeted personalized treatment, in the form of EGFR inhibitors, which are commonly used in other cancer types, could be used.

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Published date: 13 June 2013
Organisations: Human Development & Health

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Local EPrints ID: 353904
URI: http://eprints.soton.ac.uk/id/eprint/353904
ISSN: 1045-2257
PURE UUID: d1a2848a-c1d0-454d-a029-d3c1ddad219a

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Date deposited: 24 Jun 2013 13:18
Last modified: 22 Jul 2022 18:35

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Contributors

Author: Brian A. Walker
Author: Christopher P. Wardell
Author: Fiona M. Ross
Author: Gareth J. Morgan

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