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Clostridium difficile in children: a review of existing and recently uncovered evidence

Clostridium difficile in children: a review of existing and recently uncovered evidence
Clostridium difficile in children: a review of existing and recently uncovered evidence
The clinical significance of the presence of Clostridium difficile in children's faeces remains uncertain using current diagnostic procedures. Clostridium difficile is a relatively common finding in infants with no symptoms of gastrointestinal disease, suggesting it may be an incidental finding and form part of the normal gut micro-flora in this age group. On the other hand, particularly in older children or those with significant co-morbidity, there are examples where C. difficile causes disease and exerts considerable morbidity and even mortality (C. difficile infection, CDI). Between these extremes lie a substantial group of children who have both diarrhoea and C. difficile in their stools but where the nature of the association is not clear: Clostridium difficile associated disease (CDAD). We review the significance of C. difficile in children presenting recently uncovered paediatric data from a large UK epidemiological study that informs some key unanswered questions.
978-1-4614-4725-2
0065-2598
57-72
Springer
Morris, O.
8ea7e084-4f53-47cb-8f07-3961bc200b4d
Tebruegge, M.
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Pallett, A.
f6c86ce7-3eaf-4152-b176-df30f409ef22
Green, S.M.
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Pearson, A.D.
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Tuck, A.
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Clarke, S.C.
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Roderick, P.
dbb3cd11-4c51-4844-982b-0eb30ad5085a
Faust, S.N.
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Curtis, Nigel
Finn, Adam
Pollard, Andrew J.
Morris, O.
8ea7e084-4f53-47cb-8f07-3961bc200b4d
Tebruegge, M.
2c3dff22-0b5f-48a7-bb36-ce323705f74a
Pallett, A.
f6c86ce7-3eaf-4152-b176-df30f409ef22
Green, S.M.
49ee2ec8-0a25-4442-8c4e-452305669df1
Pearson, A.D.
ecaee045-d044-4ae7-bfd1-52acec89c940
Tuck, A.
90d0a731-080b-4872-8fc0-45cd71db1e2c
Clarke, S.C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Roderick, P.
dbb3cd11-4c51-4844-982b-0eb30ad5085a
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Curtis, Nigel
Finn, Adam
Pollard, Andrew J.

Morris, O., Tebruegge, M., Pallett, A., Green, S.M., Pearson, A.D., Tuck, A., Clarke, S.C., Roderick, P. and Faust, S.N. (2013) Clostridium difficile in children: a review of existing and recently uncovered evidence. In, Curtis, Nigel, Finn, Adam and Pollard, Andrew J. (eds.) Hot Topics in Infection and Immunity in Children IX. (Advances in Experimental Medicine and Biology, , (doi:10.1007/978-1-4614-4726-9_4), 764) New York, US. Springer, pp. 57-72. (doi:10.1007/978-1-4614-4726-9_4).

Record type: Book Section

Abstract

The clinical significance of the presence of Clostridium difficile in children's faeces remains uncertain using current diagnostic procedures. Clostridium difficile is a relatively common finding in infants with no symptoms of gastrointestinal disease, suggesting it may be an incidental finding and form part of the normal gut micro-flora in this age group. On the other hand, particularly in older children or those with significant co-morbidity, there are examples where C. difficile causes disease and exerts considerable morbidity and even mortality (C. difficile infection, CDI). Between these extremes lie a substantial group of children who have both diarrhoea and C. difficile in their stools but where the nature of the association is not clear: Clostridium difficile associated disease (CDAD). We review the significance of C. difficile in children presenting recently uncovered paediatric data from a large UK epidemiological study that informs some key unanswered questions.

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More information

Published date: 2013
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 353983
URI: https://eprints.soton.ac.uk/id/eprint/353983
ISBN: 978-1-4614-4725-2
ISSN: 0065-2598
PURE UUID: ac1cad9c-a006-4304-b0cc-3520f036aaf3
ORCID for S.C. Clarke: ORCID iD orcid.org/0000-0002-7009-1548
ORCID for P. Roderick: ORCID iD orcid.org/0000-0001-9475-6850
ORCID for S.N. Faust: ORCID iD orcid.org/0000-0003-3410-7642

Catalogue record

Date deposited: 26 Jun 2013 15:56
Last modified: 20 Jul 2019 01:19

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