Cognitive ability and decline after early life stress exposure
Cognitive ability and decline after early life stress exposure
We examined the effects of early life stress on cognitive ability and decline among men of the Helsinki Birth Cohort Study, 10% of whom were separated temporarily (mean age at separation = 4.1 years) from their parent(s) during World War II. The men underwent the Finnish Defense Forces Basic Intellectual Ability Test twice, at 20 years and retest at 70 years. Compared with the men without childhood separation and matched for year of birth (n = 186), men separated from their parents (n = 93) scored lower by 5.5 (95% confidence interval [CI], ?9.2 to ?1.7), 4.2 (95% CI, ?8.1 to ?0.3), 3.1 (95% CI, ?7.0 to 0.8), and 4.5 (95% CI, ?10.5 to ?1.4) standardized points (SD = 15) on verbal, visuospatial, arithmetic, and general cognitive ability, respectively, at 70 years. Longer duration of separation was associated with lower test scores. Though early life stress was also associated significantly with weaker cognitive performance at the ages 20 and 70 years, it was not associated with cognitive decline over the 50-year period within this sample
1674-1679
Pesonen, Anu-Katriina
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Eriksson, Johan G.
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Heinonen, Kati
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Kajantie, Eero
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Tuovinen, Soile
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Alastalo, Hanna
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Henriksson, Markus
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Leskinen, Jukka
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Osmond, Clive
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Barker, David J.P.
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Raikkonen, Katri
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June 2013
Pesonen, Anu-Katriina
8cc53fef-f713-425e-bd01-8f1c53842351
Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
Heinonen, Kati
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Kajantie, Eero
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Tuovinen, Soile
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Alastalo, Hanna
3a5e2504-3d51-45db-9824-31588131da94
Henriksson, Markus
a2053763-2d31-4ec1-badc-479e469c5365
Leskinen, Jukka
7cbbe375-a538-4507-8d7a-47d583ffb1c2
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Raikkonen, Katri
7f44cbef-84f3-4d77-9ccc-f026ce537dd8
Pesonen, Anu-Katriina, Eriksson, Johan G., Heinonen, Kati, Kajantie, Eero, Tuovinen, Soile, Alastalo, Hanna, Henriksson, Markus, Leskinen, Jukka, Osmond, Clive, Barker, David J.P. and Raikkonen, Katri
(2013)
Cognitive ability and decline after early life stress exposure.
Neurobiology of Aging, 34 (6), .
(doi:10.1016/j.neurobiolaging.2012.12.012.).
(PMID:23337341)
Abstract
We examined the effects of early life stress on cognitive ability and decline among men of the Helsinki Birth Cohort Study, 10% of whom were separated temporarily (mean age at separation = 4.1 years) from their parent(s) during World War II. The men underwent the Finnish Defense Forces Basic Intellectual Ability Test twice, at 20 years and retest at 70 years. Compared with the men without childhood separation and matched for year of birth (n = 186), men separated from their parents (n = 93) scored lower by 5.5 (95% confidence interval [CI], ?9.2 to ?1.7), 4.2 (95% CI, ?8.1 to ?0.3), 3.1 (95% CI, ?7.0 to 0.8), and 4.5 (95% CI, ?10.5 to ?1.4) standardized points (SD = 15) on verbal, visuospatial, arithmetic, and general cognitive ability, respectively, at 70 years. Longer duration of separation was associated with lower test scores. Though early life stress was also associated significantly with weaker cognitive performance at the ages 20 and 70 years, it was not associated with cognitive decline over the 50-year period within this sample
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Published date: June 2013
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Faculty of Medicine
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Local EPrints ID: 354029
URI: http://eprints.soton.ac.uk/id/eprint/354029
PURE UUID: fad8f9aa-a50d-427c-a075-c194cc1da762
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Date deposited: 28 Jun 2013 13:17
Last modified: 15 Mar 2024 02:50
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Author:
Anu-Katriina Pesonen
Author:
Johan G. Eriksson
Author:
Kati Heinonen
Author:
Eero Kajantie
Author:
Soile Tuovinen
Author:
Hanna Alastalo
Author:
Markus Henriksson
Author:
Jukka Leskinen
Author:
David J.P. Barker
Author:
Katri Raikkonen
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