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Cognitive ability and decline after early life stress exposure

Cognitive ability and decline after early life stress exposure
Cognitive ability and decline after early life stress exposure
We examined the effects of early life stress on cognitive ability and decline among men of the Helsinki Birth Cohort Study, 10% of whom were separated temporarily (mean age at separation = 4.1 years) from their parent(s) during World War II. The men underwent the Finnish Defense Forces Basic Intellectual Ability Test twice, at 20 years and retest at 70 years. Compared with the men without childhood separation and matched for year of birth (n = 186), men separated from their parents (n = 93) scored lower by 5.5 (95% confidence interval [CI], ?9.2 to ?1.7), 4.2 (95% CI, ?8.1 to ?0.3), 3.1 (95% CI, ?7.0 to 0.8), and 4.5 (95% CI, ?10.5 to ?1.4) standardized points (SD = 15) on verbal, visuospatial, arithmetic, and general cognitive ability, respectively, at 70 years. Longer duration of separation was associated with lower test scores. Though early life stress was also associated significantly with weaker cognitive performance at the ages 20 and 70 years, it was not associated with cognitive decline over the 50-year period within this sample
1674-1679
Pesonen, Anu-Katriina
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Eriksson, Johan G.
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Heinonen, Kati
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Kajantie, Eero
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Tuovinen, Soile
29acd896-d144-42cd-a270-653aa4c9b35a
Alastalo, Hanna
3a5e2504-3d51-45db-9824-31588131da94
Henriksson, Markus
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Leskinen, Jukka
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Osmond, Clive
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Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Raikkonen, Katri
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Pesonen, Anu-Katriina
8cc53fef-f713-425e-bd01-8f1c53842351
Eriksson, Johan G.
e95e6451-67bb-4338-803e-7af310a920ac
Heinonen, Kati
46bb57d0-1c33-4cdd-badf-d38a5fc61200
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Tuovinen, Soile
29acd896-d144-42cd-a270-653aa4c9b35a
Alastalo, Hanna
3a5e2504-3d51-45db-9824-31588131da94
Henriksson, Markus
a2053763-2d31-4ec1-badc-479e469c5365
Leskinen, Jukka
7cbbe375-a538-4507-8d7a-47d583ffb1c2
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Raikkonen, Katri
7f44cbef-84f3-4d77-9ccc-f026ce537dd8

Pesonen, Anu-Katriina, Eriksson, Johan G., Heinonen, Kati, Kajantie, Eero, Tuovinen, Soile, Alastalo, Hanna, Henriksson, Markus, Leskinen, Jukka, Osmond, Clive, Barker, David J.P. and Raikkonen, Katri (2013) Cognitive ability and decline after early life stress exposure. Neurobiology of Aging, 34 (6), 1674-1679. (doi:10.1016/j.neurobiolaging.2012.12.012.). (PMID:23337341)

Record type: Article

Abstract

We examined the effects of early life stress on cognitive ability and decline among men of the Helsinki Birth Cohort Study, 10% of whom were separated temporarily (mean age at separation = 4.1 years) from their parent(s) during World War II. The men underwent the Finnish Defense Forces Basic Intellectual Ability Test twice, at 20 years and retest at 70 years. Compared with the men without childhood separation and matched for year of birth (n = 186), men separated from their parents (n = 93) scored lower by 5.5 (95% confidence interval [CI], ?9.2 to ?1.7), 4.2 (95% CI, ?8.1 to ?0.3), 3.1 (95% CI, ?7.0 to 0.8), and 4.5 (95% CI, ?10.5 to ?1.4) standardized points (SD = 15) on verbal, visuospatial, arithmetic, and general cognitive ability, respectively, at 70 years. Longer duration of separation was associated with lower test scores. Though early life stress was also associated significantly with weaker cognitive performance at the ages 20 and 70 years, it was not associated with cognitive decline over the 50-year period within this sample

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Published date: June 2013
Organisations: Faculty of Medicine

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Local EPrints ID: 354029
URI: http://eprints.soton.ac.uk/id/eprint/354029
PURE UUID: fad8f9aa-a50d-427c-a075-c194cc1da762
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 28 Jun 2013 13:17
Last modified: 18 Feb 2021 16:45

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Contributors

Author: Anu-Katriina Pesonen
Author: Johan G. Eriksson
Author: Kati Heinonen
Author: Eero Kajantie
Author: Soile Tuovinen
Author: Hanna Alastalo
Author: Markus Henriksson
Author: Jukka Leskinen
Author: Clive Osmond ORCID iD
Author: David J.P. Barker
Author: Katri Raikkonen

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