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Maternal hypertensive disorders in pregnancy and self-reported cognitive impairment of the offspring 70 years later: the Helsinki Birth Cohort Study

Maternal hypertensive disorders in pregnancy and self-reported cognitive impairment of the offspring 70 years later: the Helsinki Birth Cohort Study
Maternal hypertensive disorders in pregnancy and self-reported cognitive impairment of the offspring 70 years later: the Helsinki Birth Cohort Study
We tested whether maternal hypertensive disorders during pregnancy predict self-reported cognitive impairment, which is one of the earliest behavioral markers of dementia, of the offspring 70 years later. We included 876 participants of the Helsinki Birth Cohort Study 1934-44 who were born after normotensive, preeclamptic, or hypertensive pregnancies that were defined by the use of the mother's blood pressure and urinary protein measurements at maternity clinics and birth hospitals. The participants completed a psychological questionnaire that included questions on cognitive failures and dysexecutive functioning at an average age of 69.3 ± 3.1 (SD) years. In comparison with the offspring who were born after normotensive pregnancies, the offspring who were born after preeclamptic pregnancies reported more frequent complaints of cognitive failures, distractibility, and false triggering. Further, among women we found maternal hypertension without proteinuria that was associated with more frequent complaints of cognitive failures, forgetfulness, and false triggering. Hypertensive disorders during pregnancy are associated with more frequent subjective complaints of cognitive failures of the offspring in old age.

adulthood, cognitive impairment, hypertensive disorders in pregnancy, offspring
0002-9378
200-209
Tuovinen, S.
3a4d8d1f-1eae-48a2-afcf-65baad23ead8
Eriksson, J.G.
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Kanjatie, E.
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Lahti, J.
522c081a-8ed6-476a-b421-f07e9c498ecb
Pesonen, A.K.
edd22dbe-e07d-4212-a476-aaff63f619f5
Heinonen, K.
667793ce-59c1-43d0-9f53-4f7790a9ed94
Osmond, C.
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Barker, D.J.
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Raikkonen, K.
926aba17-06cd-417b-b20f-ae400a2596a6
Tuovinen, S.
3a4d8d1f-1eae-48a2-afcf-65baad23ead8
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Kanjatie, E.
bf2923af-b07b-4d35-a495-55a265ebdee0
Lahti, J.
522c081a-8ed6-476a-b421-f07e9c498ecb
Pesonen, A.K.
edd22dbe-e07d-4212-a476-aaff63f619f5
Heinonen, K.
667793ce-59c1-43d0-9f53-4f7790a9ed94
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Raikkonen, K.
926aba17-06cd-417b-b20f-ae400a2596a6

Tuovinen, S., Eriksson, J.G., Kanjatie, E., Lahti, J., Pesonen, A.K., Heinonen, K., Osmond, C., Barker, D.J. and Raikkonen, K. (2013) Maternal hypertensive disorders in pregnancy and self-reported cognitive impairment of the offspring 70 years later: the Helsinki Birth Cohort Study. American Journal of Obstetrics and Gynecology, 208 (3), 200-209. (doi:10.1016/j.ajog.2012.12.017). (PMID:23246316)

Record type: Article

Abstract

We tested whether maternal hypertensive disorders during pregnancy predict self-reported cognitive impairment, which is one of the earliest behavioral markers of dementia, of the offspring 70 years later. We included 876 participants of the Helsinki Birth Cohort Study 1934-44 who were born after normotensive, preeclamptic, or hypertensive pregnancies that were defined by the use of the mother's blood pressure and urinary protein measurements at maternity clinics and birth hospitals. The participants completed a psychological questionnaire that included questions on cognitive failures and dysexecutive functioning at an average age of 69.3 ± 3.1 (SD) years. In comparison with the offspring who were born after normotensive pregnancies, the offspring who were born after preeclamptic pregnancies reported more frequent complaints of cognitive failures, distractibility, and false triggering. Further, among women we found maternal hypertension without proteinuria that was associated with more frequent complaints of cognitive failures, forgetfulness, and false triggering. Hypertensive disorders during pregnancy are associated with more frequent subjective complaints of cognitive failures of the offspring in old age.

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Published date: March 2013
Keywords: adulthood, cognitive impairment, hypertensive disorders in pregnancy, offspring
Organisations: Faculty of Medicine

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Local EPrints ID: 354108
URI: http://eprints.soton.ac.uk/id/eprint/354108
ISSN: 0002-9378
PURE UUID: bf08a1a4-6249-4b53-bc67-7d2d03d1459f
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 01 Jul 2013 13:07
Last modified: 18 Feb 2021 16:45

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Contributors

Author: S. Tuovinen
Author: J.G. Eriksson
Author: E. Kanjatie
Author: J. Lahti
Author: A.K. Pesonen
Author: K. Heinonen
Author: C. Osmond ORCID iD
Author: D.J. Barker
Author: K. Raikkonen

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