Statistical mechanics of pluripotency
Statistical mechanics of pluripotency
Recent reports using single cell profiling have indicated a remarkably dynamic view of pluripotent stem cell identity. Here, we argue that the pluripotent state is not well defined at the single cell level, but rather is a statistical property of stem cell populations, amenable to analysis using the tools of statistical mechanics and information theory.
484-489
MacArthur, Ben D.
2c0476e7-5d3e-4064-81bb-104e8e88bb6b
Lemischka, Ihor R.
3deafa24-f76b-4bfa-90e3-e2b802786bdc
1 August 2013
MacArthur, Ben D.
2c0476e7-5d3e-4064-81bb-104e8e88bb6b
Lemischka, Ihor R.
3deafa24-f76b-4bfa-90e3-e2b802786bdc
Abstract
Recent reports using single cell profiling have indicated a remarkably dynamic view of pluripotent stem cell identity. Here, we argue that the pluripotent state is not well defined at the single cell level, but rather is a statistical property of stem cell populations, amenable to analysis using the tools of statistical mechanics and information theory.
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Published date: 1 August 2013
Organisations:
Applied Mathematics
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Local EPrints ID: 354364
URI: http://eprints.soton.ac.uk/id/eprint/354364
ISSN: 0092-8674
PURE UUID: dc645321-e51a-49c7-8d7d-4d56c0f0d1b6
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Date deposited: 09 Jul 2013 11:03
Last modified: 15 Mar 2024 03:07
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Author:
Ihor R. Lemischka
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