Pulsatile spinal cord surrogate for intradural neuromodulation studies
Pulsatile spinal cord surrogate for intradural neuromodulation studies
We have designed, built and tested a novel spinal cord surrogate that mimics the low-amplitude cardiac-driven pulsations of the human spinal cord, for use in developing intradural implants to be used in a novel form of neuromodulation for the treatment of intractable pain and motor system dysfunction. The silicone surrogate has an oval cross section, 10?mm major axis?×?6?mm minor axis, and incorporates a 3?mm diameter?×?3?cm long angioplasty balloon that serves as the pulsation actuator. When pneumatically driven at 1 Hz and 1.5 atmospheres (? 1140?mm Hg), the surrogate’s diametric pulsation is ? 100 ?m, which corresponds well to in vivo observations. The applications for this surrogate are presented and discussed.
spinal cord, neuromodulation, tissue surrogates, pial surface, intradural devices
22-25
Wilson, S.
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Howard, M.A.
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Rossen, J.D.
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Brennan, T.J.
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Dalm, B.D.
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Dahdaleh, N.S.
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Utz, M.
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Gillies, G.T.
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January 2012
Wilson, S.
95286d3e-048c-44a0-ad36-2897805b385a
Howard, M.A.
5853860b-4960-48d3-8465-0fe7caf81735
Rossen, J.D.
b472bafb-c208-4075-ba9e-1c66fb9e2156
Brennan, T.J.
cd43c266-1b51-4b35-8995-2e90b8b8732d
Dalm, B.D.
d99315e5-aead-42c2-bcf1-da51f9e82d5f
Dahdaleh, N.S.
8eab3aa7-0650-4fe2-b009-7e4c24c919ec
Utz, M.
c84ed64c-9e89-4051-af39-d401e423891b
Gillies, G.T.
07b4a1d6-26b3-4ace-883f-6e0761abe93d
Wilson, S., Howard, M.A., Rossen, J.D., Brennan, T.J., Dalm, B.D., Dahdaleh, N.S., Utz, M. and Gillies, G.T.
(2012)
Pulsatile spinal cord surrogate for intradural neuromodulation studies.
Journal of Medical Engineering & Technology, 36 (1), .
(doi:10.3109/03091902.2011.632061).
(PMID:22188575)
Abstract
We have designed, built and tested a novel spinal cord surrogate that mimics the low-amplitude cardiac-driven pulsations of the human spinal cord, for use in developing intradural implants to be used in a novel form of neuromodulation for the treatment of intractable pain and motor system dysfunction. The silicone surrogate has an oval cross section, 10?mm major axis?×?6?mm minor axis, and incorporates a 3?mm diameter?×?3?cm long angioplasty balloon that serves as the pulsation actuator. When pneumatically driven at 1 Hz and 1.5 atmospheres (? 1140?mm Hg), the surrogate’s diametric pulsation is ? 100 ?m, which corresponds well to in vivo observations. The applications for this surrogate are presented and discussed.
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Published date: January 2012
Keywords:
spinal cord, neuromodulation, tissue surrogates, pial surface, intradural devices
Organisations:
Magnetic Resonance
Identifiers
Local EPrints ID: 354762
URI: http://eprints.soton.ac.uk/id/eprint/354762
PURE UUID: 3ad6f695-0f3d-4c3d-8ed5-d9e09a457caf
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Date deposited: 22 Jul 2013 12:53
Last modified: 15 Mar 2024 03:44
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Contributors
Author:
S. Wilson
Author:
M.A. Howard
Author:
J.D. Rossen
Author:
T.J. Brennan
Author:
B.D. Dalm
Author:
N.S. Dahdaleh
Author:
G.T. Gillies
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