Biophysical attributes of an in vitro spinal cord surrogate for use in developing an intradural neuromodulation system
Biophysical attributes of an in vitro spinal cord surrogate for use in developing an intradural neuromodulation system
We have developed a spinal cord surrogate for use in testing a pial-surface spinal cord stimulator. Our surrogate is of a commercially available silicone mix, has an oval cross-sectional area that matches that of actual human spinal cord at the lower thoracic level, and has measured values of durometer A?=?(10.96?±?1.68), durometer O?=?(14.76?±?1.48), and durometer OO?=?(50.24?±?2.65). These correspond to model-inferred elastic moduli of 0.41 to 0.44 MPa, which match well with the existing low-strain rate measurements of ex vivo human spinal cord. Upcoming applications for this surrogate in developmental studies of the new stimulator system are discussed.
bioelectric phenomena, biomechanics, biomedical materials, elastic moduli, hardness, neurophysiology, silicone rubber
74701
Howard, M. A.
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Utz, M.
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Brennan, T. J.
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Dalm, B. D.
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Viljoen, S.
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Kanwal, J. K.
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Gillies, G. T.
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4 October 2011
Howard, M. A.
4da33423-1860-43d4-8d2e-b46e6076b565
Utz, M.
c84ed64c-9e89-4051-af39-d401e423891b
Brennan, T. J.
c1e1c240-8f53-47ce-b618-89c395ad7bcd
Dalm, B. D.
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Viljoen, S.
abaec7f2-c634-4139-be42-30c4fa40c608
Kanwal, J. K.
63212738-7746-4e30-92ca-8f334c4f7973
Gillies, G. T.
028ef1e5-99d1-474c-a6e0-e764018a88d1
Howard, M. A., Utz, M., Brennan, T. J., Dalm, B. D., Viljoen, S., Kanwal, J. K. and Gillies, G. T.
(2011)
Biophysical attributes of an in vitro spinal cord surrogate for use in developing an intradural neuromodulation system.
Journal of Applied Physics, 110, .
(doi:10.1063/1.3642976).
Abstract
We have developed a spinal cord surrogate for use in testing a pial-surface spinal cord stimulator. Our surrogate is of a commercially available silicone mix, has an oval cross-sectional area that matches that of actual human spinal cord at the lower thoracic level, and has measured values of durometer A?=?(10.96?±?1.68), durometer O?=?(14.76?±?1.48), and durometer OO?=?(50.24?±?2.65). These correspond to model-inferred elastic moduli of 0.41 to 0.44 MPa, which match well with the existing low-strain rate measurements of ex vivo human spinal cord. Upcoming applications for this surrogate in developmental studies of the new stimulator system are discussed.
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Published date: 4 October 2011
Keywords:
bioelectric phenomena, biomechanics, biomedical materials, elastic moduli, hardness, neurophysiology, silicone rubber
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Magnetic Resonance
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Local EPrints ID: 354773
URI: http://eprints.soton.ac.uk/id/eprint/354773
ISSN: 0021-8979
PURE UUID: 5b7902f4-cb38-49f6-be86-764f4227fb17
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Date deposited: 22 Jul 2013 13:11
Last modified: 15 Mar 2024 03:44
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Author:
M. A. Howard
Author:
T. J. Brennan
Author:
B. D. Dalm
Author:
S. Viljoen
Author:
J. K. Kanwal
Author:
G. T. Gillies
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