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Tissue engineering techniques in cardiac repair and disease modelling

Tissue engineering techniques in cardiac repair and disease modelling
Tissue engineering techniques in cardiac repair and disease modelling
Cell therapy has been proposed to treat patients with end-stage heart failure. However, it has been suggested that the significant mechanical forces in an often ischaemic, inflamed, biochemically hostile environment may cause poor cell survival and retention. It is hypothesised that tissue engineering techniques could be used to modify the environment to improve the efficacy of cell therapy. Similarly, it has been suggested that tissue engineering technology could be used to mature the phenotype of immature cardiomyocytes in vitro, making them more useful disease models. In this review we will briefly discuss key tissue engineering techniques and principles that can be used to facilitate cell therapy, and modify the phenotype of immature cardiomyocytes and stem cells.
Rao, C.
20f2d12e-20a6-4c86-9174-f1e7a7441ad3
Barratt, H.
c89243e8-ea9c-43fc-a626-798484770a40
Prodromakis, T.
d58c9c10-9d25-4d22-b155-06c8437acfbf
Terracciano, C.M.
79bb2862-f4c4-42b1-929c-3043b5bc8794
Rao, C.
20f2d12e-20a6-4c86-9174-f1e7a7441ad3
Barratt, H.
c89243e8-ea9c-43fc-a626-798484770a40
Prodromakis, T.
d58c9c10-9d25-4d22-b155-06c8437acfbf
Terracciano, C.M.
79bb2862-f4c4-42b1-929c-3043b5bc8794

Rao, C., Barratt, H., Prodromakis, T. and Terracciano, C.M. (2013) Tissue engineering techniques in cardiac repair and disease modelling. Current Pharmaceutical Design. (doi:10.2174/13816128113199990442). (PMID:23844730)

Record type: Article

Abstract

Cell therapy has been proposed to treat patients with end-stage heart failure. However, it has been suggested that the significant mechanical forces in an often ischaemic, inflamed, biochemically hostile environment may cause poor cell survival and retention. It is hypothesised that tissue engineering techniques could be used to modify the environment to improve the efficacy of cell therapy. Similarly, it has been suggested that tissue engineering technology could be used to mature the phenotype of immature cardiomyocytes in vitro, making them more useful disease models. In this review we will briefly discuss key tissue engineering techniques and principles that can be used to facilitate cell therapy, and modify the phenotype of immature cardiomyocytes and stem cells.

Other 23844730 - Other
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Accepted/In Press date: 2013
e-pub ahead of print date: 18 June 2013
Organisations: Nanoelectronics and Nanotechnology

Identifiers

Local EPrints ID: 354915
URI: https://eprints.soton.ac.uk/id/eprint/354915
PURE UUID: 5e012b30-f8aa-4f08-bb84-96e623614f7f

Catalogue record

Date deposited: 07 Aug 2013 14:09
Last modified: 18 Jul 2017 03:52

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Contributors

Author: C. Rao
Author: H. Barratt
Author: T. Prodromakis
Author: C.M. Terracciano

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