The biology of Neisseria Adhesins
The biology of Neisseria Adhesins
Members of the genus Neisseria include pathogens causing important human diseases such as meningitis, septicaemia, gonorrhoea and pelvic inflammatory disease syndrome. Neisseriae are found on the exposed epithelia of the upper respiratory tract and the urogenital tract. Colonisation of these exposed epithelia is dependent on a repertoire of diverse bacterial molecules, extending not only from the surface of the bacteria but also found within the outer membrane. During invasive disease, pathogenic Neisseriae also interact with immune effector cells, vascular endothelia and the meninges. Neisseria adhesion involves the interplay of these multiple surface factors and in this review we discuss the structure and function of these important molecules and the nature of the host cell receptors and mechanisms involved in their recognition. We also describe the current status for recently identified Neisseria adhesins. Understanding the biology of Neisseria adhesins has an impact not only on the development of new vaccines but also in revealing fundamental knowledge about human biology.
neisseria, meningitis, gonorrhoea, bacterial adhesin, host cell receptor, structure
1054-1109
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Hung, Miao-Chiu
53d4bf2c-4e0e-4c77-9385-218350560fdb
29 July 2013
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Hung, Miao-Chiu
53d4bf2c-4e0e-4c77-9385-218350560fdb
Christodoulides, Myron and Hung, Miao-Chiu
(2013)
The biology of Neisseria Adhesins.
[in special issue: Bacterial Adhesion]
Biology, 2 (3), .
(doi:10.3390/biology2031054).
Abstract
Members of the genus Neisseria include pathogens causing important human diseases such as meningitis, septicaemia, gonorrhoea and pelvic inflammatory disease syndrome. Neisseriae are found on the exposed epithelia of the upper respiratory tract and the urogenital tract. Colonisation of these exposed epithelia is dependent on a repertoire of diverse bacterial molecules, extending not only from the surface of the bacteria but also found within the outer membrane. During invasive disease, pathogenic Neisseriae also interact with immune effector cells, vascular endothelia and the meninges. Neisseria adhesion involves the interplay of these multiple surface factors and in this review we discuss the structure and function of these important molecules and the nature of the host cell receptors and mechanisms involved in their recognition. We also describe the current status for recently identified Neisseria adhesins. Understanding the biology of Neisseria adhesins has an impact not only on the development of new vaccines but also in revealing fundamental knowledge about human biology.
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Published date: 29 July 2013
Keywords:
neisseria, meningitis, gonorrhoea, bacterial adhesin, host cell receptor, structure
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 355167
URI: http://eprints.soton.ac.uk/id/eprint/355167
PURE UUID: 0d726172-02b4-4d92-8c59-4649f4caa882
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Date deposited: 13 Aug 2013 10:45
Last modified: 15 Mar 2024 03:52
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