The University of Southampton
University of Southampton Institutional Repository

High bone mass is associated with an increased prevalence of joint replacement: a case-control study

High bone mass is associated with an increased prevalence of joint replacement: a case-control study
High bone mass is associated with an increased prevalence of joint replacement: a case-control study
Objective. Epidemiological studies have shown an association between OA and increased BMD. To explore the nature of this relationship, we examined whether the risk of OA is increased in individuals with high bone mass (HBM), in whom BMD is assumed to be elevated due to a primary genetic cause.

Methods. A total of 335 115 DXA scans were screened to identify HBM index cases (defined by DXA scan as an L1 Z-score of ?+3.2 and total hip Z-score ?+1.2, or total hip Z-score ?+3.2 and L1 Z-score ?+1.2). In relatives, the definition of HBM was L1 Z-score plus total hip Z-score ?+3.2. Controls comprised unaffected relatives and spouses. Clinical indicators of OA were determined by structured assessment. Analyses used logistic regression adjusting for age, gender, BMI and social deprivation.

Results. A total of 353 HBM cases (mean age 61.7 years, 77% female) and 197 controls (mean age 54.1 years, 47% female) were included. Adjusted NSAID use was more prevalent in HBM cases versus controls [odds ratio (OR) 2.17 (95% CI 1.10, 4.28); P = 0.03]. The prevalence of joint replacement was higher in HBM cases (13.0%) than controls (4.1%), with an adjusted OR of 2.42 (95% CI 1.06, 5.56); P = 0.04. Adjusted prevalence of joint pain and knee crepitus did not differ between cases and controls.

Conclusion. HBM is associated with increased prevalence of joint replacement surgery and NSAID use compared with unaffected controls.
osteoarthritis, high bone mass, bone mineral density, dxa, joint replacement
1462-0324
1042-1051
Hardcastle, S.A.
5d3e434f-9f5c-4044-8f6e-753fa8748cde
Gregson, C.L.
fc84c2dd-c427-486f-a212-3e3549cb5cdf
Deere, K.C.
bb592666-61f3-4fa1-bce8-ec85af289e25
Davey Smith, G.
cb29a020-3ad3-4bcd-95dc-a1a43d4fe26f
Dieppe, P.
293f54b1-2f1a-4dd1-ad56-88ab75dab64e
Tobias, J.H.
de2ae2cb-8547-475a-98e0-9d5169b8deb7
Hardcastle, S.A.
5d3e434f-9f5c-4044-8f6e-753fa8748cde
Gregson, C.L.
fc84c2dd-c427-486f-a212-3e3549cb5cdf
Deere, K.C.
bb592666-61f3-4fa1-bce8-ec85af289e25
Davey Smith, G.
cb29a020-3ad3-4bcd-95dc-a1a43d4fe26f
Dieppe, P.
293f54b1-2f1a-4dd1-ad56-88ab75dab64e
Tobias, J.H.
de2ae2cb-8547-475a-98e0-9d5169b8deb7

Hardcastle, S.A., Gregson, C.L., Deere, K.C., Davey Smith, G., Dieppe, P. and Tobias, J.H. (2013) High bone mass is associated with an increased prevalence of joint replacement: a case-control study. Rheumatology, 52 (6), 1042-1051. (doi:10.1093/rheumatology/kes411.). (PMID:23362220)

Record type: Article

Abstract

Objective. Epidemiological studies have shown an association between OA and increased BMD. To explore the nature of this relationship, we examined whether the risk of OA is increased in individuals with high bone mass (HBM), in whom BMD is assumed to be elevated due to a primary genetic cause.

Methods. A total of 335 115 DXA scans were screened to identify HBM index cases (defined by DXA scan as an L1 Z-score of ?+3.2 and total hip Z-score ?+1.2, or total hip Z-score ?+3.2 and L1 Z-score ?+1.2). In relatives, the definition of HBM was L1 Z-score plus total hip Z-score ?+3.2. Controls comprised unaffected relatives and spouses. Clinical indicators of OA were determined by structured assessment. Analyses used logistic regression adjusting for age, gender, BMI and social deprivation.

Results. A total of 353 HBM cases (mean age 61.7 years, 77% female) and 197 controls (mean age 54.1 years, 47% female) were included. Adjusted NSAID use was more prevalent in HBM cases versus controls [odds ratio (OR) 2.17 (95% CI 1.10, 4.28); P = 0.03]. The prevalence of joint replacement was higher in HBM cases (13.0%) than controls (4.1%), with an adjusted OR of 2.42 (95% CI 1.06, 5.56); P = 0.04. Adjusted prevalence of joint pain and knee crepitus did not differ between cases and controls.

Conclusion. HBM is associated with increased prevalence of joint replacement surgery and NSAID use compared with unaffected controls.

Text
Gregson High bone mass is associated with.pdf - Other
Restricted to Repository staff only

More information

Published date: June 2013
Keywords: osteoarthritis, high bone mass, bone mineral density, dxa, joint replacement
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 355264
URI: http://eprints.soton.ac.uk/id/eprint/355264
ISSN: 1462-0324
PURE UUID: 9b6a7032-a008-4538-a892-3090c7f29067

Catalogue record

Date deposited: 19 Aug 2013 13:57
Last modified: 27 Oct 2023 02:59

Export record

Altmetrics

Contributors

Author: S.A. Hardcastle
Author: C.L. Gregson
Author: K.C. Deere
Author: G. Davey Smith
Author: P. Dieppe
Author: J.H. Tobias

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×