Emerging applications for phospho-proteomics in cancer molecular therapeutics
Emerging applications for phospho-proteomics in cancer molecular therapeutics
Protein phosphorylation is a key mechanism of cell regulation in normal and cancer cells. Various new cancer drugs and drug candidates are aimed at protein kinase targets. However, selecting patients likely to respond to these treatments, even among individuals with tumors expressing validated kinase targets remains a major challenge. There exists a need for biomarkers to facilitate the monitoring of modulation of drug-targeted kinase pathways. Phospho-proteomics involves the enrichment of phosphorylated proteins from tissue, and the application of technologies such as mass spectrometry (MS) for the identification and quantification of protein phosphorylation sites. It has potential to provide pharmacodynamic readouts of disease states and cellular drug responses in tumor samples, but technical hurdles and bioinformatics challenges will need to be addressed.
phospho-peptide, mass spectrometry, protein kinase, phosphorylation, biomarker, epidermal growth factor
230-241
Moran, Michael F.
06cac0b7-f94b-4546-83e3-02ea958eecc8
Tong, Jiefei
0cd0c6a4-92ae-4fad-b4f0-6856db1f479b
Taylor, Paul
648ece00-6e9a-433d-bc21-e5007de25029
Ewing, Robert M.
022c5b04-da20-4e55-8088-44d0dc9935ae
December 2006
Moran, Michael F.
06cac0b7-f94b-4546-83e3-02ea958eecc8
Tong, Jiefei
0cd0c6a4-92ae-4fad-b4f0-6856db1f479b
Taylor, Paul
648ece00-6e9a-433d-bc21-e5007de25029
Ewing, Robert M.
022c5b04-da20-4e55-8088-44d0dc9935ae
Moran, Michael F., Tong, Jiefei, Taylor, Paul and Ewing, Robert M.
(2006)
Emerging applications for phospho-proteomics in cancer molecular therapeutics.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1766 (2), .
(doi:10.1016/j.bbcan.2006.06.002).
(PMID:16889898)
Abstract
Protein phosphorylation is a key mechanism of cell regulation in normal and cancer cells. Various new cancer drugs and drug candidates are aimed at protein kinase targets. However, selecting patients likely to respond to these treatments, even among individuals with tumors expressing validated kinase targets remains a major challenge. There exists a need for biomarkers to facilitate the monitoring of modulation of drug-targeted kinase pathways. Phospho-proteomics involves the enrichment of phosphorylated proteins from tissue, and the application of technologies such as mass spectrometry (MS) for the identification and quantification of protein phosphorylation sites. It has potential to provide pharmacodynamic readouts of disease states and cellular drug responses in tumor samples, but technical hurdles and bioinformatics challenges will need to be addressed.
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Published date: December 2006
Keywords:
phospho-peptide, mass spectrometry, protein kinase, phosphorylation, biomarker, epidermal growth factor
Organisations:
Molecular and Cellular
Identifiers
Local EPrints ID: 355384
URI: http://eprints.soton.ac.uk/id/eprint/355384
ISSN: 0304-419X
PURE UUID: 6f0b116d-e7a0-4f13-84c9-fcb958449b59
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Date deposited: 22 Oct 2013 10:53
Last modified: 15 Mar 2024 03:44
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Author:
Michael F. Moran
Author:
Jiefei Tong
Author:
Paul Taylor
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