Animal models and programming of the metabolic syndrome. Type 2 diabetes
Animal models and programming of the metabolic syndrome. Type 2 diabetes
The purpose of this review is to consider how current animal models of fetal programming contribute to knowledge of the metabolic syndrome in adult humans. Low birth weight infants have an increased risk of developing cardiovascular and coronary heart disease, hypertension, diabetes and stroke in adulthood. A number of animal studies confirm the association between events during fetal life and subsequent adult disease. This review considers how these have contributed to our understanding of this relationship, and how they may help to uncover the underlying mechanisms. The importance of dietary, pharmacological, genetic and surgical models is assessed, and their usefulness in the prevention of human disease evaluated. Although progress has been made, further investigations using animals are needed to clarify the mechanisms involved in the programming of adult disease. Once these processes are understood, it may be possible to identify and protect at-risk individuals.
0199224846
103-121
Bertram, Caroline
bd8d2058-c047-4dd6-a1f2-8191fcbe1b08
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
November 2001
Bertram, Caroline
bd8d2058-c047-4dd6-a1f2-8191fcbe1b08
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Bertram, Caroline and Hanson, Mark A.
(2001)
Animal models and programming of the metabolic syndrome. Type 2 diabetes.
British Medical Bulletin, 60, .
(doi:10.1093/bmb/60.1.103).
Abstract
The purpose of this review is to consider how current animal models of fetal programming contribute to knowledge of the metabolic syndrome in adult humans. Low birth weight infants have an increased risk of developing cardiovascular and coronary heart disease, hypertension, diabetes and stroke in adulthood. A number of animal studies confirm the association between events during fetal life and subsequent adult disease. This review considers how these have contributed to our understanding of this relationship, and how they may help to uncover the underlying mechanisms. The importance of dietary, pharmacological, genetic and surgical models is assessed, and their usefulness in the prevention of human disease evaluated. Although progress has been made, further investigations using animals are needed to clarify the mechanisms involved in the programming of adult disease. Once these processes are understood, it may be possible to identify and protect at-risk individuals.
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Published date: November 2001
Organisations:
Human Development & Health
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Local EPrints ID: 355486
URI: http://eprints.soton.ac.uk/id/eprint/355486
ISBN: 0199224846
PURE UUID: d5c86108-38b4-4d22-a6c5-f264cba54289
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Date deposited: 25 Nov 2013 14:42
Last modified: 17 Mar 2024 02:51
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Author:
Caroline Bertram
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