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Animal models and the programming of the metabolic syndrome

Animal models and the programming of the metabolic syndrome
Animal models and the programming of the metabolic syndrome
The purpose of this review is to consider how current animal models of fetal programming contribute to knowledge of the metabolic syndrome in adult humans. Low birth weight infants have an increased risk of developing cardiovascular and coronary heart disease, hypertension, diabetes and stroke in adulthood. A number of animal studies confirm the association between events during fetal life and subsequent adult disease. This review considers how these have contributed to our understanding of this relationship, and how they may help to uncover the underlying mechanisms. The importance of dietary, pharmacological, genetic and surgical models is assessed, and their usefulness in the prevention of human disease evaluated. Although progress has been made, further investigations using animals are needed to clarify the mechanisms involved in the programming of adult disease. Once these processes are understood, it may be possible to identify and protect at-risk individuals.
0199224846
60.1
103-121
Oxford University Press for the British Council
Bertram, Caroline
bd8d2058-c047-4dd6-a1f2-8191fcbe1b08
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Barker, David
Bertram, Caroline
bd8d2058-c047-4dd6-a1f2-8191fcbe1b08
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Barker, David

Bertram, Caroline and Hanson, Mark A. (2001) Animal models and the programming of the metabolic syndrome. In, Barker, David (ed.) Type 2 Diabetes: The Thrifty Phenotype. (British Medical Bulletin, , (doi:10.1093/bmb/60.1.103), 60.1) Oxford, GB. Oxford University Press for the British Council, pp. 103-121. (doi:10.1093/bmb/60.1.103).

Record type: Book Section

Abstract

The purpose of this review is to consider how current animal models of fetal programming contribute to knowledge of the metabolic syndrome in adult humans. Low birth weight infants have an increased risk of developing cardiovascular and coronary heart disease, hypertension, diabetes and stroke in adulthood. A number of animal studies confirm the association between events during fetal life and subsequent adult disease. This review considers how these have contributed to our understanding of this relationship, and how they may help to uncover the underlying mechanisms. The importance of dietary, pharmacological, genetic and surgical models is assessed, and their usefulness in the prevention of human disease evaluated. Although progress has been made, further investigations using animals are needed to clarify the mechanisms involved in the programming of adult disease. Once these processes are understood, it may be possible to identify and protect at-risk individuals.

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More information

Published date: November 2001
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 355486
URI: https://eprints.soton.ac.uk/id/eprint/355486
ISBN: 0199224846
PURE UUID: d5c86108-38b4-4d22-a6c5-f264cba54289
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

Catalogue record

Date deposited: 25 Nov 2013 14:42
Last modified: 27 Jul 2018 00:34

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