The University of Southampton
University of Southampton Institutional Repository

Nonalcoholic Fatty Liver Disease and Reduced Serum Vitamin D3 levels

Nonalcoholic Fatty Liver Disease and Reduced Serum Vitamin D3 levels
Nonalcoholic Fatty Liver Disease and Reduced Serum Vitamin D3 levels
Abstract Nonalcoholic fatty liver disease (NAFLD) and vitamin D3 deficiency are two highly prevalent pathologic conditions worldwide that share several cardiometabolic risk factors. In addition to its traditional calcium-related effects on the skeleton, vitamin D3 deficiency has now been recognized to exert nonskeletal adverse effects on several other organ systems. Accumulating epidemiological evidence suggests that low levels of serum 25-hydroxyvitamin D3 are associated with the presence and severity of NAFLD, independently of several potential confounders, including features of the metabolic syndrome. The molecular mechanisms of this association remain incompletely understood. A variety of biologically plausible mechanisms may mediate a hepato-protective role for the active metabolite of vitamin D3. 1?,25-dihydroxyvitamin D3 modulates the insulin signaling pathway/insulin resistance, suppresses fibroblast proliferation and collagen production, exerts anticoagulant and profibrinolytic effects, and modulates macrophage activity and inflammatory cytokine generation. Overall, the high prevalence of vitamin D3 deficiency and the plausible biological mechanisms linking this to NAFLD suggest that treatment of vitamin D3 deficiency to prevent and/or treat NAFLD is a promising field to explore. Large placebo-controlled randomized clinical trials are urgently needed to determine whether vitamin D3 supplementation could have any potential benefit in reducing the development and progression of NAFLD.
1540-4196
217-228
Targher, Giovanni
043e0811-b389-4922-974e-22e650212c5f
Scorletti, Eleonora
4e896544-2974-4f81-9696-1595d3c36814
Mantovani, Alessandro
19fc8a1f-60fe-403a-b70e-6b6884929e03
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni
043e0811-b389-4922-974e-22e650212c5f
Scorletti, Eleonora
4e896544-2974-4f81-9696-1595d3c36814
Mantovani, Alessandro
19fc8a1f-60fe-403a-b70e-6b6884929e03
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c

Targher, Giovanni, Scorletti, Eleonora, Mantovani, Alessandro and Byrne, Christopher D. (2013) Nonalcoholic Fatty Liver Disease and Reduced Serum Vitamin D3 levels. Metabolic Syndrome and Related Disorders, 11 (4), 217-228. (doi:10.1089/met.2013.0044). (PMID:23745619)

Record type: Article

Abstract

Abstract Nonalcoholic fatty liver disease (NAFLD) and vitamin D3 deficiency are two highly prevalent pathologic conditions worldwide that share several cardiometabolic risk factors. In addition to its traditional calcium-related effects on the skeleton, vitamin D3 deficiency has now been recognized to exert nonskeletal adverse effects on several other organ systems. Accumulating epidemiological evidence suggests that low levels of serum 25-hydroxyvitamin D3 are associated with the presence and severity of NAFLD, independently of several potential confounders, including features of the metabolic syndrome. The molecular mechanisms of this association remain incompletely understood. A variety of biologically plausible mechanisms may mediate a hepato-protective role for the active metabolite of vitamin D3. 1?,25-dihydroxyvitamin D3 modulates the insulin signaling pathway/insulin resistance, suppresses fibroblast proliferation and collagen production, exerts anticoagulant and profibrinolytic effects, and modulates macrophage activity and inflammatory cytokine generation. Overall, the high prevalence of vitamin D3 deficiency and the plausible biological mechanisms linking this to NAFLD suggest that treatment of vitamin D3 deficiency to prevent and/or treat NAFLD is a promising field to explore. Large placebo-controlled randomized clinical trials are urgently needed to determine whether vitamin D3 supplementation could have any potential benefit in reducing the development and progression of NAFLD.

This record has no associated files available for download.

More information

Published date: August 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 355586
URI: http://eprints.soton.ac.uk/id/eprint/355586
ISSN: 1540-4196
PURE UUID: fb7703ac-d38d-48ec-b1d3-8d9781c89a12
ORCID for Christopher D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

Catalogue record

Date deposited: 22 Aug 2013 14:07
Last modified: 09 Jan 2022 03:00

Export record

Altmetrics

Contributors

Author: Giovanni Targher
Author: Eleonora Scorletti
Author: Alessandro Mantovani

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×