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Tuberculosis: Time for a new perspective?

Tuberculosis: Time for a new perspective?
Tuberculosis: Time for a new perspective?
Transmission of Mycobacterium tuberculosis (Mtb) continues uninterrupted. Pre-exposure vaccination remains a central focus of tuberculosis research but 25 years of follow up is needed to determine whether a novel childhood vaccination regime protects from adult disease, or like BCG assists Mtb dissemination by preventing childhood illness but not infective adult pulmonary tuberculosis. Therefore, different strategies to interrupt the life cycle of Mtb need to be explored. This personal perspective discusses alternative approaches that may be delivered in a shorter time frame.
tuberculosis, transmission, diagnosis, lung matrix
0163-4453
299-302
Elkington, P.T.G.
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Elkington, P.T.G.
60828c7c-3d32-47c9-9fcc-6c4c54c35a15

Elkington, P.T.G. (2013) Tuberculosis: Time for a new perspective? Journal of Infection, 66 (4), 299-302. (doi:10.1016/j.jinf.2013.02.002). (PMID:23415730)

Record type: Article

Abstract

Transmission of Mycobacterium tuberculosis (Mtb) continues uninterrupted. Pre-exposure vaccination remains a central focus of tuberculosis research but 25 years of follow up is needed to determine whether a novel childhood vaccination regime protects from adult disease, or like BCG assists Mtb dissemination by preventing childhood illness but not infective adult pulmonary tuberculosis. Therefore, different strategies to interrupt the life cycle of Mtb need to be explored. This personal perspective discusses alternative approaches that may be delivered in a shorter time frame.

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More information

Published date: April 2013
Keywords: tuberculosis, transmission, diagnosis, lung matrix
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 355592
URI: http://eprints.soton.ac.uk/id/eprint/355592
DOI: doi:10.1016/j.jinf.2013.02.002
ISSN: 0163-4453
PURE UUID: bf1df059-92b8-41ad-94fc-64dbced7ec1e
ORCID for P.T.G. Elkington: ORCID iD orcid.org/0000-0003-0390-0613

Catalogue record

Date deposited: 02 Sep 2013 15:50
Last modified: 15 Mar 2024 03:43

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Author: P.T.G. Elkington ORCID iD

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