The University of Southampton
University of Southampton Institutional Repository

Relation of elevated serum uric acid levels to incidence of atrial fibrillation in patients with Type 2 Diabetes Mellitus

Relation of elevated serum uric acid levels to incidence of atrial fibrillation in patients with Type 2 Diabetes Mellitus
Relation of elevated serum uric acid levels to incidence of atrial fibrillation in patients with Type 2 Diabetes Mellitus
The association between serum uric acid (SUA) levels and atrial fibrillation (AF) is currently poorly known. We examined the association between SUA levels and risk of incident AF in patients with type 2 diabetes mellitus. We followed for 10 years a random sample of 400 type 2 diabetic outpatients, who were free from AF at baseline. A standard 12-lead electrocardiography was undertaken annually and a diagnosis of incident AF was confirmed in affected participants by a single cardiologist. Over 10 years, there were 42 incident AF cases (cumulative incidence of 10.5%). Elevated SUA level was associated with an increased risk of incident AF (odds ratio 2.43, 95% confidence interval 1.8 to 3.4, p <0.0001 for each 1-SD increase in SUA level). Adjustments for age, gender, body mass index, hypertension, chronic kidney disease, electrocardiographic features (left ventricular hypertrophy and PR interval), and use of diuretics and allopurinol did not attenuate the association between SUA and incident AF (adjusted odds ratio 2.44, 95% confidence interval 1.6 to 3.9, p <0.0001). Further adjustment for variables that were included in the 10-year Framingham Heart Study-derived AF risk score did not appreciably weaken this association. Results remained unchanged even when SUA was modeled as a categorical variable (stratifying by either SUA median or hyperuricemia), and when patients with previous coronary heart disease or heart failure were excluded from analysis. In conclusion, our findings suggest that elevated SUA levels are strongly associated with an increased incidence of AF in patients with type 2 diabetes mellitus even after adjustment for multiple clinical risk factors for AF.
0002-9149
499-504
Valbusa, F.
d9aafe28-7ce5-4893-af8c-4ece09ddc2e2
Bertolini, L.
98d540f4-9422-4c2c-92d1-2383c3798ca3
Bonapace, S.
3bf688b2-0f7e-4e5b-8011-c353a93bf675
Zenari, L.
3caeb6f8-b4ee-477d-8fdc-661a773204ad
Zoppini, G.
21719d3f-197a-43ba-a955-366ea9ac0764
Arcaro, G.
f30031f6-5315-4398-817d-a62c8498ec36
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Targher, G.
5a842bd2-91c4-4063-b639-da6c681f3698
Valbusa, F.
d9aafe28-7ce5-4893-af8c-4ece09ddc2e2
Bertolini, L.
98d540f4-9422-4c2c-92d1-2383c3798ca3
Bonapace, S.
3bf688b2-0f7e-4e5b-8011-c353a93bf675
Zenari, L.
3caeb6f8-b4ee-477d-8fdc-661a773204ad
Zoppini, G.
21719d3f-197a-43ba-a955-366ea9ac0764
Arcaro, G.
f30031f6-5315-4398-817d-a62c8498ec36
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Targher, G.
5a842bd2-91c4-4063-b639-da6c681f3698

Valbusa, F., Bertolini, L., Bonapace, S., Zenari, L., Zoppini, G., Arcaro, G., Byrne, Christopher D. and Targher, G. (2013) Relation of elevated serum uric acid levels to incidence of atrial fibrillation in patients with Type 2 Diabetes Mellitus. The American Journal of Cardiology, 112 (4), 499-504. (doi:10.1016/j.amjcard.2013.04.012). (PMID:23672990)

Record type: Article

Abstract

The association between serum uric acid (SUA) levels and atrial fibrillation (AF) is currently poorly known. We examined the association between SUA levels and risk of incident AF in patients with type 2 diabetes mellitus. We followed for 10 years a random sample of 400 type 2 diabetic outpatients, who were free from AF at baseline. A standard 12-lead electrocardiography was undertaken annually and a diagnosis of incident AF was confirmed in affected participants by a single cardiologist. Over 10 years, there were 42 incident AF cases (cumulative incidence of 10.5%). Elevated SUA level was associated with an increased risk of incident AF (odds ratio 2.43, 95% confidence interval 1.8 to 3.4, p <0.0001 for each 1-SD increase in SUA level). Adjustments for age, gender, body mass index, hypertension, chronic kidney disease, electrocardiographic features (left ventricular hypertrophy and PR interval), and use of diuretics and allopurinol did not attenuate the association between SUA and incident AF (adjusted odds ratio 2.44, 95% confidence interval 1.6 to 3.9, p <0.0001). Further adjustment for variables that were included in the 10-year Framingham Heart Study-derived AF risk score did not appreciably weaken this association. Results remained unchanged even when SUA was modeled as a categorical variable (stratifying by either SUA median or hyperuricemia), and when patients with previous coronary heart disease or heart failure were excluded from analysis. In conclusion, our findings suggest that elevated SUA levels are strongly associated with an increased incidence of AF in patients with type 2 diabetes mellitus even after adjustment for multiple clinical risk factors for AF.

This record has no associated files available for download.

More information

Published date: 15 August 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 355595
URI: http://eprints.soton.ac.uk/id/eprint/355595
ISSN: 0002-9149
PURE UUID: 487b3e92-d320-4235-803c-9ad3dab57e46
ORCID for Christopher D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

Catalogue record

Date deposited: 03 Sep 2013 08:54
Last modified: 23 Jul 2022 01:45

Export record

Altmetrics

Contributors

Author: F. Valbusa
Author: L. Bertolini
Author: S. Bonapace
Author: L. Zenari
Author: G. Zoppini
Author: G. Arcaro
Author: G. Targher

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×