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IL-6 is a predictive biomarker for stroke associated infection and future mortality in the elderly after an ischemic stroke

IL-6 is a predictive biomarker for stroke associated infection and future mortality in the elderly after an ischemic stroke
IL-6 is a predictive biomarker for stroke associated infection and future mortality in the elderly after an ischemic stroke
Background and purpose
Stroke associated infection (within the first seven days) occurs in approximately half of stroke patients and is associated with a worse prognosis, especially in the elderly. It is uncertain what factors predict stroke associated infection, yet identification of a suitable biomarker for infection may allow early and appropriate intervention with antibiotics. The aims of this study were to: a) identify independent risk factors for stroke associated infection, and b) test relationships between these risk factors and mortality at 2 years.

Methods
Eight-two elderly patients were assessed within 72 h of stroke. Data on stroke severity (Barthel Index), stroke associated infection and mortality at 2 years were collected. Inflammatory biomarkers at baseline and 6 months were measured by ELISA. Logistic regression was used to identify risk factors for stroke associated infection and death.

Results
Patients with stroke associated infection, especially pneumonia, had increased IL-6, more severe strokes, and higher mortality. IL-6 was independently associated with stroke associated infection (OR = 19.2, [95%CI 3.68, 100], p < 0.001), after adjustment for other risk factors and cytokines. IL-6 was also independently associated with 2 year mortality (OR = 9.2, [1.0, 85.1], p = 0.031).

Conclusions
These data suggest that IL-6 may be a key biomarker for predicting stroke associated infection and mortality in the first two years post stroke.
stroke, biomarker, IL-6, infection, mortality, risk factors
0531-5565
960-965
Kwan, Joseph
2f6e316b-60bc-48a4-8b96-464b965ea6a5
Horsfield, G.
19927dea-2701-42f0-8341-87445138b630
Bryant, T.
6cc3c2b2-6dd5-46fc-bbf7-496f4e3483d8
Gawne-Caine, M.
db55c4ce-8583-439c-8fc6-c4071bdf10c3
Durward, G.
3ba82f94-03d2-4c38-9e06-4da8a5226e16
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
Englyst, N.A.
f84399af-7265-4224-b556-102c3aa272b0
Kwan, Joseph
2f6e316b-60bc-48a4-8b96-464b965ea6a5
Horsfield, G.
19927dea-2701-42f0-8341-87445138b630
Bryant, T.
6cc3c2b2-6dd5-46fc-bbf7-496f4e3483d8
Gawne-Caine, M.
db55c4ce-8583-439c-8fc6-c4071bdf10c3
Durward, G.
3ba82f94-03d2-4c38-9e06-4da8a5226e16
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
Englyst, N.A.
f84399af-7265-4224-b556-102c3aa272b0

Kwan, Joseph, Horsfield, G., Bryant, T., Gawne-Caine, M., Durward, G., Byrne, C.D. and Englyst, N.A. (2013) IL-6 is a predictive biomarker for stroke associated infection and future mortality in the elderly after an ischemic stroke. Experimental Gerontology, 48 (9), 960-965. (doi:10.1016/j.exger.2013.07.003). (PMID:23872300)

Record type: Article

Abstract

Background and purpose
Stroke associated infection (within the first seven days) occurs in approximately half of stroke patients and is associated with a worse prognosis, especially in the elderly. It is uncertain what factors predict stroke associated infection, yet identification of a suitable biomarker for infection may allow early and appropriate intervention with antibiotics. The aims of this study were to: a) identify independent risk factors for stroke associated infection, and b) test relationships between these risk factors and mortality at 2 years.

Methods
Eight-two elderly patients were assessed within 72 h of stroke. Data on stroke severity (Barthel Index), stroke associated infection and mortality at 2 years were collected. Inflammatory biomarkers at baseline and 6 months were measured by ELISA. Logistic regression was used to identify risk factors for stroke associated infection and death.

Results
Patients with stroke associated infection, especially pneumonia, had increased IL-6, more severe strokes, and higher mortality. IL-6 was independently associated with stroke associated infection (OR = 19.2, [95%CI 3.68, 100], p < 0.001), after adjustment for other risk factors and cytokines. IL-6 was also independently associated with 2 year mortality (OR = 9.2, [1.0, 85.1], p = 0.031).

Conclusions
These data suggest that IL-6 may be a key biomarker for predicting stroke associated infection and mortality in the first two years post stroke.

Full text not available from this repository.

More information

Published date: September 2013
Keywords: stroke, biomarker, IL-6, infection, mortality, risk factors
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 355650
URI: http://eprints.soton.ac.uk/id/eprint/355650
ISSN: 0531-5565
PURE UUID: 9404cc9c-647d-4c87-94d0-39d5f8840026
ORCID for C.D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753
ORCID for N.A. Englyst: ORCID iD orcid.org/0000-0003-0508-8323

Catalogue record

Date deposited: 03 Sep 2013 12:22
Last modified: 18 Feb 2021 16:55

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Contributors

Author: Joseph Kwan
Author: G. Horsfield
Author: T. Bryant
Author: M. Gawne-Caine
Author: G. Durward
Author: C.D. Byrne ORCID iD
Author: N.A. Englyst ORCID iD

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