Identification of viable embryos by noninvasive measurement of amino acids in culture media

Houghton, Franchesca D. (2013) Identification of viable embryos by noninvasive measurement of amino acids in culture media. In, Gardner, David K., Sakkas, Denny, Seli, Emre and Wells, Dagan (eds.) Human Gametes and Preimplantation Embryos Assessment and Diagnosis. Springer, pp. 267-273. (doi:10.1007/978-1-4614-6651-2_24).

Record type: Book Section

Abstract

This chapter highlights many important roles of amino acids for human preimplantation embryos. Amino acids are not only beneficial to embryo development but their utilisation by the embryo is also predictive of future viability, genetic health, DNA damage and trophectoderm integrity. These findings were remarkable and highlight how integral amino acids are to the physiology of the embryo. Thus, it is important that much consideration is given to the media used in clinical IVF. This will require suppliers to provide details of media formulations so that informed choices can be made. The use of amino acid profiling in a clinical setting offers the exciting prospect to nonsubjectively select the most developmentally competent embryo for transfer with the greatest chance of producing a live birth.

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