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A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin ? C as a compatible prognostic marker in human solid tumors.

A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin ? C as a compatible prognostic marker in human solid tumors.
A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin ? C as a compatible prognostic marker in human solid tumors.
Our findings provide IGKC as a novel diagnostic marker for risk stratification in human cancer and support concepts to exploit the humoral immune response for anticancer therapy. It could be validated in several independent cohorts and carried out similarly well in RNA from fresh frozen as well as from paraffin tissue and on protein level by immunostaining.
1078-0432
2695-2703
Schmidt, Marcus
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Hellwig, Birte
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Hammad, Seddik
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Othman, Amnah
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Lohr, Miriam
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Chen, Zonglin
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Boehm, Daniel
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Gebhard, Susanne
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Petry, Ilka
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Lebrecht, Antje
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Cadenas, Cristina
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Marchan, Rosemarie
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Stewart, Joanna D
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Solbach, Christine
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Holmberg, Lars
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Edlund, Karolina
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Kultima, Hanna Göransson
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Rody, Achim
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Berglund, Anders
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Lambe, Mats
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Isaksson, Anders
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Botling, Johan
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Karn, Thomas
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Müller, Volkmar
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Gerhold-Ay, Aslihan
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Cotarelo, Christina
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Sebastian, Martin
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Kronenwett, Ralf
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Bojar, Hans
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Lehr, Hans-Anton
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Sahin, Ugur
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Koelbl, Heinz
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Gehrmann, Mathias
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Micke, Patrick
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Rahnenführer, Jörg
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Hengstler, Jan G
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Schmidt, Marcus
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Hellwig, Birte
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Hammad, Seddik
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Othman, Amnah
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Lohr, Miriam
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Chen, Zonglin
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Boehm, Daniel
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Gebhard, Susanne
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Petry, Ilka
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Cadenas, Cristina
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Marchan, Rosemarie
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Stewart, Joanna D
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Solbach, Christine
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Holmberg, Lars
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Edlund, Karolina
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Kultima, Hanna Göransson
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Rody, Achim
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Berglund, Anders
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Lambe, Mats
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Isaksson, Anders
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Botling, Johan
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Karn, Thomas
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Müller, Volkmar
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Gerhold-Ay, Aslihan
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Cotarelo, Christina
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Sebastian, Martin
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Kronenwett, Ralf
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Bojar, Hans
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Lehr, Hans-Anton
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Sahin, Ugur
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Koelbl, Heinz
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Gehrmann, Mathias
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Micke, Patrick
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Rahnenführer, Jörg
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Hengstler, Jan G
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Schmidt, Marcus, Hellwig, Birte, Hammad, Seddik, Othman, Amnah, Lohr, Miriam, Chen, Zonglin, Boehm, Daniel, Gebhard, Susanne, Petry, Ilka, Lebrecht, Antje, Cadenas, Cristina, Marchan, Rosemarie, Stewart, Joanna D, Solbach, Christine, Holmberg, Lars, Edlund, Karolina, Kultima, Hanna Göransson, Rody, Achim, Berglund, Anders, Lambe, Mats, Isaksson, Anders, Botling, Johan, Karn, Thomas, Müller, Volkmar, Gerhold-Ay, Aslihan, Cotarelo, Christina, Sebastian, Martin, Kronenwett, Ralf, Bojar, Hans, Lehr, Hans-Anton, Sahin, Ugur, Koelbl, Heinz, Gehrmann, Mathias, Micke, Patrick, Rahnenführer, Jörg and Hengstler, Jan G (2012) A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin ? C as a compatible prognostic marker in human solid tumors. Clinical Cancer Research, 18 (9), 2695-2703. (doi:10.1158/1078-0432.CCR-12-0566). (PMID:22442060)

Record type: Article

Abstract

Our findings provide IGKC as a novel diagnostic marker for risk stratification in human cancer and support concepts to exploit the humoral immune response for anticancer therapy. It could be validated in several independent cohorts and carried out similarly well in RNA from fresh frozen as well as from paraffin tissue and on protein level by immunostaining.

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Published date: 1 May 2012
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Organisations: Centre for Biological Sciences
Learn more about Biological Sciences research

Identifiers

Local EPrints ID: 355916
URI: http://eprints.soton.ac.uk/id/eprint/355916
DOI: doi:10.1158/1078-0432.CCR-12-0566
ISSN: 1078-0432
PURE UUID: b569e24f-0c18-4a6f-bdf3-bf274326d07f
ORCID for Joanna D Stewart: ORCID iD orcid.org/0000-0002-2608-1967

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Date deposited: 04 Sep 2013 16:38
Last modified: 14 Mar 2024 14:40

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Contributors

Author: Marcus Schmidt
Author: Birte Hellwig
Author: Seddik Hammad
Author: Amnah Othman
Author: Miriam Lohr
Author: Zonglin Chen
Author: Daniel Boehm
Author: Susanne Gebhard
Author: Ilka Petry
Author: Antje Lebrecht
Author: Cristina Cadenas
Author: Rosemarie Marchan
Author: Joanna D Stewart ORCID iD
Author: Christine Solbach
Author: Lars Holmberg
Author: Karolina Edlund
Author: Hanna Göransson Kultima
Author: Achim Rody
Author: Anders Berglund
Author: Mats Lambe
Author: Anders Isaksson
Author: Johan Botling
Author: Thomas Karn
Author: Volkmar Müller
Author: Aslihan Gerhold-Ay
Author: Christina Cotarelo
Author: Martin Sebastian
Author: Ralf Kronenwett
Author: Hans Bojar
Author: Hans-Anton Lehr
Author: Ugur Sahin
Author: Heinz Koelbl
Author: Mathias Gehrmann
Author: Patrick Micke
Author: Jörg Rahnenführer
Author: Jan G Hengstler

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