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Microfluidic and lab-on-a-chip preparation routes for organic nanoparticles and vesicular systems for nanomedicine applications

Microfluidic and lab-on-a-chip preparation routes for organic nanoparticles and vesicular systems for nanomedicine applications
Microfluidic and lab-on-a-chip preparation routes for organic nanoparticles and vesicular systems for nanomedicine applications
In recent years, advancements in the fields of microfluidic and lab-on-a-chip technologies have provided unique opportunities for the implementation of nanomaterial production processes owing to the miniaturisation of the fluidic environment. It has been demonstrated that microfluidic reactors offer a range of advantages compared to conventional batch reactors, including improved controllability and uniformity of nanomaterial characteristics. In addition, the fast mixing achieved within microchannels, and the predictability of the laminar flow conditions,can be leveraged to investigate the nanomaterial formation dynamics. In this article recent developments in the field of microfluidic production of nanomaterials for drug delivery applications are reviewed. The features that make microfluidic reactors a suitable technological platform are discussed in terms of controllability of nanomaterials production. An overview of the various strategies developed for the production of organic nanoparticles and colloidal assemblies is presented, focusing on those nanomaterials that could have an impact on nanomedicine field such as drug nanoparticles, polymeric micelles, liposomes, polymersomes, polyplexes and hybrid nanoparticles. The effect of microfluidic environment on nanomaterials formation dynamics, as well as the use of microdevices as tools for nanomaterial investigation is also discussed.
micro?uidic, lab-on-a-chip, nanomedicine, nanomaterial, polymeric micelles, liposomes, polymersomes
0169-409X
1496-1532
Capretto, Lorenzo
0f3586b5-1560-49c1-a76b-59e74ea600ef
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Mazzitelli, Stefania
d9923ab4-b354-4b9e-87d1-f67d86e1a8dc
Nastruzzi, Claudio
fa760f44-1546-4aa2-838d-242a908ea463
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Capretto, Lorenzo
0f3586b5-1560-49c1-a76b-59e74ea600ef
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Mazzitelli, Stefania
d9923ab4-b354-4b9e-87d1-f67d86e1a8dc
Nastruzzi, Claudio
fa760f44-1546-4aa2-838d-242a908ea463
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1

Capretto, Lorenzo, Carugo, Dario, Mazzitelli, Stefania, Nastruzzi, Claudio and Zhang, Xunli (2013) Microfluidic and lab-on-a-chip preparation routes for organic nanoparticles and vesicular systems for nanomedicine applications. Advanced Drug Delivery Reviews, 65 (11-12), 1496-1532. (doi:10.1016/j.addr.2013.08.002). (PMID:23933616)

Record type: Article

Abstract

In recent years, advancements in the fields of microfluidic and lab-on-a-chip technologies have provided unique opportunities for the implementation of nanomaterial production processes owing to the miniaturisation of the fluidic environment. It has been demonstrated that microfluidic reactors offer a range of advantages compared to conventional batch reactors, including improved controllability and uniformity of nanomaterial characteristics. In addition, the fast mixing achieved within microchannels, and the predictability of the laminar flow conditions,can be leveraged to investigate the nanomaterial formation dynamics. In this article recent developments in the field of microfluidic production of nanomaterials for drug delivery applications are reviewed. The features that make microfluidic reactors a suitable technological platform are discussed in terms of controllability of nanomaterials production. An overview of the various strategies developed for the production of organic nanoparticles and colloidal assemblies is presented, focusing on those nanomaterials that could have an impact on nanomedicine field such as drug nanoparticles, polymeric micelles, liposomes, polymersomes, polyplexes and hybrid nanoparticles. The effect of microfluidic environment on nanomaterials formation dynamics, as well as the use of microdevices as tools for nanomaterial investigation is also discussed.

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More information

e-pub ahead of print date: 8 August 2013
Published date: November 2013
Keywords: micro?uidic, lab-on-a-chip, nanomedicine, nanomaterial, polymeric micelles, liposomes, polymersomes
Organisations: Bioengineering Group, Mechatronics

Identifiers

Local EPrints ID: 355942
URI: https://eprints.soton.ac.uk/id/eprint/355942
ISSN: 0169-409X
PURE UUID: e5938167-9622-4a27-a2f3-57d18f5042ca

Catalogue record

Date deposited: 21 Aug 2013 11:56
Last modified: 16 Jul 2019 21:25

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Contributors

Author: Lorenzo Capretto
Author: Dario Carugo
Author: Stefania Mazzitelli
Author: Claudio Nastruzzi
Author: Xunli Zhang

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