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Insulin-like growth factor-I (IGF-I) misue in athletes and potential methods for detection

Insulin-like growth factor-I (IGF-I) misue in athletes and potential methods for detection
Insulin-like growth factor-I (IGF-I) misue in athletes and potential methods for detection
To athletes, insulin-like growth factor-I (IGF-I) is an attractive performance-enhancing drug, particularly as an alternative to growth hormone (GH) because IGF-I mediates many of the anabolic actions of GH. IGF-I has beneficial effects on muscle protein synthesis and glycogen storage that could enhance performance in several sporting disciplines. Recombinant human IGF-I (rhIGF-I) is used in clinical practice, but a variety of IGF-I compounds and IGF-I analogues are also advertised on the internet and many have been available on the black market for several years. Although methods for detecting GH misuse are now well established and there have been several cases in which athletes have tested positive for GH, no test is yet in place for detecting IGF-I misuse. The GH-2004 research group has been investigating methods for detection of IGF-I misuse and a test is being developed on the basis of the principles of the successful GH-2000 marker method, in which markers from the IGF axis and markers of collagen and bone turnover are used to detect GH misuse. Commercial immunoassays for these markers have been validated for anti-doping purposes but new methods, including IGF-I measurement by use of mass spectrometry, should improve the performance of the tests and help in the detection of athletes who are doping with these peptide hormones.
igf-i, growth hormone, doping
1618-2642
Guha, Nishan
38212040-a65e-4874-a60a-21f0ae3bdf09
Cowan, David A.
2e7e5fbb-acdc-4763-8108-3984d26b00c5
Sonksen, Peter H.
b3cf05ef-65c2-4e9b-8d95-b7c3aaf532cd
Holt, R.I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
Guha, Nishan
38212040-a65e-4874-a60a-21f0ae3bdf09
Cowan, David A.
2e7e5fbb-acdc-4763-8108-3984d26b00c5
Sonksen, Peter H.
b3cf05ef-65c2-4e9b-8d95-b7c3aaf532cd
Holt, R.I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393

Guha, Nishan, Cowan, David A., Sonksen, Peter H. and Holt, R.I.G. (2013) Insulin-like growth factor-I (IGF-I) misue in athletes and potential methods for detection. Analytical and Bioanalytical Chemistry. (doi:10.1007/s00216-013-7229-y).

Record type: Article

Abstract

To athletes, insulin-like growth factor-I (IGF-I) is an attractive performance-enhancing drug, particularly as an alternative to growth hormone (GH) because IGF-I mediates many of the anabolic actions of GH. IGF-I has beneficial effects on muscle protein synthesis and glycogen storage that could enhance performance in several sporting disciplines. Recombinant human IGF-I (rhIGF-I) is used in clinical practice, but a variety of IGF-I compounds and IGF-I analogues are also advertised on the internet and many have been available on the black market for several years. Although methods for detecting GH misuse are now well established and there have been several cases in which athletes have tested positive for GH, no test is yet in place for detecting IGF-I misuse. The GH-2004 research group has been investigating methods for detection of IGF-I misuse and a test is being developed on the basis of the principles of the successful GH-2000 marker method, in which markers from the IGF axis and markers of collagen and bone turnover are used to detect GH misuse. Commercial immunoassays for these markers have been validated for anti-doping purposes but new methods, including IGF-I measurement by use of mass spectrometry, should improve the performance of the tests and help in the detection of athletes who are doping with these peptide hormones.

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More information

e-pub ahead of print date: 11 August 2013
Keywords: igf-i, growth hormone, doping
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 355999
URI: http://eprints.soton.ac.uk/id/eprint/355999
ISSN: 1618-2642
PURE UUID: 58200c6d-8da7-42d1-86c8-68d44d170c41
ORCID for R.I.G. Holt: ORCID iD orcid.org/0000-0001-8911-6744

Catalogue record

Date deposited: 09 Sep 2013 15:41
Last modified: 08 Jan 2022 02:53

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Contributors

Author: Nishan Guha
Author: David A. Cowan
Author: Peter H. Sonksen
Author: R.I.G. Holt ORCID iD

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