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Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma.

Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma.
Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma.
Neuroblastoma associated with the paraneoplastic syndrome of opsoclonus-myoclonus is well-described. However, presentation with narcolepsy-cataplexy is not well-documented in the literature. Narcolepsy with cataplexy is also rare in children younger than 5 years of age. Here we describe three patients, each presenting in early childhood with complex neurological symptoms including narcolepsy with cataplexy that were subsequently found to have paraspinal neuroblastoma. In two of the cases, neurological symptoms resolved with treatment of the tumor and/or immunosuppression, but in one case, the child persistently had a devastating course despite complete resection of the tumor and aggressive immunosuppression.
64-67
Sinsioco, Claudine
da3dd1ae-b46c-4702-bcb4-1dd3ff62727f
Silver, Kenneth
0b6497a6-cd2a-4be1-b4aa-9815b56c0479
Forrest, Katharine M.
93f2bb17-da4d-43a3-9f52-1842f558b85e
Gray, Juliet
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Nechay, Alla
fc6e0e79-de84-431a-9e93-639cf304ab64
Sheldon, Stephen
0a317d53-5f22-470d-9016-67dd15cb40b2
Chelmicka Schorr, Ewa
3861792d-c387-4fc5-8e90-0f2be2fc55ed
Sinsioco, Claudine
da3dd1ae-b46c-4702-bcb4-1dd3ff62727f
Silver, Kenneth
0b6497a6-cd2a-4be1-b4aa-9815b56c0479
Forrest, Katharine M.
93f2bb17-da4d-43a3-9f52-1842f558b85e
Gray, Juliet
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Nechay, Alla
fc6e0e79-de84-431a-9e93-639cf304ab64
Sheldon, Stephen
0a317d53-5f22-470d-9016-67dd15cb40b2
Chelmicka Schorr, Ewa
3861792d-c387-4fc5-8e90-0f2be2fc55ed

Sinsioco, Claudine, Silver, Kenneth, Forrest, Katharine M., Gray, Juliet, Nechay, Alla, Sheldon, Stephen and Chelmicka Schorr, Ewa (2013) Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma. Pediatric Neurology, 49 (1), 64-67. (doi:10.1016/j.pediatrneurol.2012.12.038). (PMID:23827430)

Record type: Article

Abstract

Neuroblastoma associated with the paraneoplastic syndrome of opsoclonus-myoclonus is well-described. However, presentation with narcolepsy-cataplexy is not well-documented in the literature. Narcolepsy with cataplexy is also rare in children younger than 5 years of age. Here we describe three patients, each presenting in early childhood with complex neurological symptoms including narcolepsy with cataplexy that were subsequently found to have paraspinal neuroblastoma. In two of the cases, neurological symptoms resolved with treatment of the tumor and/or immunosuppression, but in one case, the child persistently had a devastating course despite complete resection of the tumor and aggressive immunosuppression.

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Published date: July 2013
Organisations: Faculty of Medicine

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Local EPrints ID: 356007
URI: http://eprints.soton.ac.uk/id/eprint/356007
PURE UUID: 353db99f-e0b6-46d1-9106-646706493cfc
ORCID for Juliet Gray: ORCID iD orcid.org/0000-0002-5652-4722

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Date deposited: 10 Sep 2013 08:53
Last modified: 18 Feb 2021 17:01

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Contributors

Author: Claudine Sinsioco
Author: Kenneth Silver
Author: Katharine M. Forrest
Author: Juliet Gray ORCID iD
Author: Alla Nechay
Author: Stephen Sheldon
Author: Ewa Chelmicka Schorr

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