Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

Chubb, Daniel, Weinhold, Niels, Broderick, Peter, Chen, Bowang, Johnson, David C., Försti, Asta, Vijayakrishnan, Jayaram, Migliorini, Gabriele, Dobbins, Sara E., Holroyd, Amy, Hose, Dirk, Walker, Brian A., Davies, Faith E., Gregory, Walter A., Jackson, Graham H., Irving, Julie A., Pratt, Guy, Fegan, Chris, Fenton, James A.L., Neben, Kai, Hoffmann, Per, Nöthen, Markus M., Mühleisen, Thomas W., Eisele, Lewin, Ross, Fiona M., Straka, Christian, Einsele, Hermann, Langer, Christian, Dörner, Elisabeth, Allan, James M., Jauch, Anna, Morgan, Gareth J., Hemminki, Kari, Houlston, Richard S. and Goldschmidt, Hartmut (2013) Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nature Genetics, 45 (10), 1221-1225. (doi:10.1038/ng.2733). (PMID:23955597)

Abstract

To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10-14), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10-11), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10-9) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10-16). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.

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